The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.
Metabolic engineering of cyanobacteria for the synthesis of commodity products
Abstract
Through metabolic engineering cyanobacteria can be employed in biotechnology. Combining the capacity for oxygenic photosynthesis and carbon fixation with an engineered metabolic pathway allows carbon-based product formation from CO(2), light, and water directly. Such cyanobacterial 'cell factories' are constructed to produce biofuels, bioplastics, and commodity chemicals. Efforts of metabolic engineers and synthetic biologists allow the modification of the intermediary metabolism at various branching points, expanding the product range. The new biosynthesis routes 'tap' the metabolism ever more efficiently, particularly through the engineering of driving forces and utilization of cofactors generated during the light reactions of photosynthesis, resulting in higher product titers. High rates of carbon rechanneling ultimately allow an almost-complete allocation of fixed carbon to product above biomass.
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“native regulatory networks resist carbon flux redirection”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [19]
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“cultivation constraints—including light attenuation in dense cultures and mismatches between photosynthetic ATP/NADPH supply and heterologous pathway demand—further limit achievable yields.”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [19]
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Metadata
- Authors
- Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Hellingwerf, Klaas J.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 33
- Issue
- 6
- Pages
- 352-361
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2134069782
- Cited by
- 273
- References
- 94
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 10 · 2022: 30 · 2021: 22 · 2020: 30 · 2019: 37 · 2018: 38 · 2017: 30 · 2016: 33 · 2015: 8
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- cyanobacteria, metabolic engineering, cell factories, biofuels, bioplastics, commodity chemicals, photosynthetic carbon fixation, oxygenic photosynthesis, metabolic pathway engineering, product titer
- MeSH terms
- Cyanobacteria, Biotechnology, Carbon Dioxide, Humans, Light, Photosynthesis, Plastics, Biomass, Biofuels, Synthetic Biology, Metabolic Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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