Cited by 20Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionPhotosynthetic Processes and Mechanisms

Application of Cyanobacteria as Chassis Cells in Synthetic Biology

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Liu, Xueli, Tang, Kaixin, Hu, Jinlu·2024·Microorganisms

Abstract

Synthetic biology is an exciting new area of research that combines science and engineering to design and build new biological functions and systems. Predictably, with the development of synthetic biology, more efficient and economical photosynthetic microalgae chassis will be successfully constructed, making it possible to break through laboratory research into large-scale industrial applications. The synthesis of a range of biochemicals has been demonstrated in cyanobacteria; however, low product titers are the biggest barrier to the commercialization of cyanobacterial biotechnology. This review summarizes the applied improvement strategies from the perspectives of cyanobacteria chassis cells and synthetic biology. The harvest advantages of cyanobacterial products and the latest progress in improving production strategies are discussed according to the product status. As cyanobacteria synthetic biology is still in its infancy, apart from the achievements made, the difficulties and challenges in the application and development of cyanobacteria genetic tool kits in biochemical synthesis, environmental monitoring, and remediation were assessed.

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Crossref · 10.3390/microorganisms12071375

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  • Such tools allow researchers to construct heterologous metabolic pathways, alternative metabolic networks, and regulate gene expression to optimise metabolic flux within engineered systems.

    “Such tools allow researchers to construct heterologous metabolic pathways, alternative metabolic networks, and regulate gene expression to optimise metabolic flux within engineered systems [50].”

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Authors
Liu, X., Tang, K., & Hu, J.
Affiliations
Northwestern Polytechnical University (CN)
Corresponding author
Hu, Jinlu
Venue
Microorganisms
Publisher
MDPI AG
Published
2024-07-05
Volume
12
Issue
7
Pages
1375
ISSN
2076-2607 (ISSN-L)
OpenAlex
W4400364082
Cited by
20
References
157
Citations by year
2026: 11 · 2025: 9
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
  • Microorganisms (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (32270128)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords
cyanobacteria, chassis cells, synthetic biology, photosynthetic microalgae, biochemical production, product titer, genetic engineering tools, environmental monitoring, bioremediation, industrial biotechnology

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