Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., et al. (2015) · Nature · doi:10.1038/nature15373 · Cited by 1,795

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Schöttler, S., Becker, G., Winzen, S., Steinbach, T., Mohr, K., Landfester, K., Mailänder, V., & Wurm, F. R. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.330 · Cited by 1,272

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,271

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246

Activatable luminescent probes for imaging brain diseases

Li, Z., Wang, C., Zhang, M., Li, S., Mao, Z., & Liu, Z. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101239 · Cited by 23

PAMAM Dendritic Nanoparticle-Incorporated Hydrogel to Enhance the Immunogenic Cell Death and Immune Response of Immunochemotherapy

Hanurry, E. Y., Birhan, Y. S., Darge, H. F., Mekonnen, T. W., Arunagiri, V., Chou, H., Cheng, C., Lai, J., & Tsai, H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00171 · Cited by 24

Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer’s disease

Unnisa, A., Greig, N. H., & Kamal, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369096 · Cited by 23

H7K(R2)2-modified pH-sensitive self-assembled nanoparticles delivering small interfering RNA targeting hepatoma-derived growth factor for malignant glioma treatment

Zhou, M., Jiang, N., Fan, J., Fu, S., Luo, H., Su, P., Zhang, M., Shi, H., Zeng, J., Huang, Y., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.08.010 · Cited by 24

Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities

Lange, J., Zhou, H., & McTague, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.941528 · Cited by 22

The siRNAsome: A Cation‐Free and Versatile Nanostructure for siRNA and Drug Co‐delivery

Zheng, M., Jiang, T., Yang, W., Zou, Y., Wu, H., Liu, X., Zhu, F., Qian, R., Ling, D., McDonald, K. L., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201814289 · Cited by 21

In Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer’s Disease Therapy

Lee, D., Shen, A. M., Shah, M., Garbuzenko, O. B., & Minko, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910357 · Cited by 20

Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Conejos‐Sánchez, I., Gallon, E., Niño‐Pariente, A., Smith, J. A., de la Fuente, A. G., Canio, L. D., Pluchino, S., Franklin, R. J. M., & Vicent, M. J. (2019) · Nanoscale · doi:10.1039/c9nr06187h · Cited by 21

Progress and perspectives on nanoplatforms for drug delivery to the brain

Xu, Y., Wei, L., & Wang, H. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101636 · Cited by 20

An in vitro model for studying CNS white matter: functional properties and experimental approaches

Bijland, S., Thomson, G., Euston, M., Michail, K., Thümmler, K., Mücklisch, S., Crawford, C. L., Barnett, S. C., McLaughlin, M., Anderson, T. J., et al. (2019) · F1000Research · doi:10.12688/f1000research.16802.1 · Cited by 17

Bioreducible Zinc(II)–Dipicolylamine Functionalized Hyaluronic Acid Mediates Safe siRNA Delivery and Effective Glioblastoma RNAi Therapy

Zheng, M., Yang, Z., Chen, S., Wu, H., Liu, Y., Wright, A. L., Lu, J., Xia, X., Lee, A., Zhang, J., et al. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00622 · Cited by 19

An overview of hyaluronic-acid nanoparticles for cancer cell targeted drug delivery

Andreana, I., Zoratto, N., Meo, C. D., Matricardi, P., Stella, B., & Arpicco, S. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2515266 · Cited by 18

Nanomedicine against Alzheimer’s and Parkinson’s Disease

Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201021140904 · Cited by 20

ROS-responsive nanomodulators downregulate IFITM3 expression and eliminate ROS for Alzheimer’s disease combination treatment

Xu, H., & Liu, Y. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.139 · Cited by 20

Systemic Delivery of Small Interfering RNA Therapeutics: Obstacles and Advances

Chandela, A., & Ueno, Y. (2019) · Reviews in Agricultural Science · doi:10.7831/ras.7.10 · Cited by 19

Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures

Martins, A. S. G., Reis, S., Benson, E., Domingues, M. M., Cortinhas, J., Silva, J. A. V., Santos, S. D., Santos, N. C., Pêgo, A. P., & Moreno, P. M. D. (2024) · Small · doi:10.1002/smll.202309140 · Cited by 17

Current Insights of Nanocarrier-Mediated Gene Therapeutics to Treat Potential Impairment of Amyloid Beta Protein and Tau Protein in Alzheimer’s Disease

Jain, U., Johari, S., & Srivastava, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03671-7 · Cited by 16

Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction

Gong, C., Wang, W. J., Ma, Y., Zhan, X., Peng, A., Pu, J., Yang, J., & Wang, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02966-8 · Cited by 15

Multimodal Nanoregulator Rescues Impaired Neurovascular Units to Attenuate Secondary Injury Following Traumatic Brain Injury

Zhang, P., Jiang, Y., Li, X., Xu, Y., Geng, T., Luo, F., Li, W., Jin, X., & Qi, J. (2025) · Advanced Materials · doi:10.1002/adma.202509444 · Cited by 15

Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy

Zheng, M., Yan, C., Yang, Q., Zhu, F., Du, Q., Xia, X., Morsch, M., Lee, A., Yin, J., Zou, Y., et al. (2022) · ChemPhysMater · doi:10.1016/j.chphma.2022.01.001 · Cited by 15

Biomimetic Nanosystems for the Synergistic Delivery of miR-144/451a for Oral Squamous Cell Carcinoma

Li, K., Qiu, Y., Liu, X., & Huang, F. (2022) · Balkan Medical Journal · doi:10.4274/balkanmedj.galenos.2022.2021-11-1 · Cited by 15

Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems

Shah, Z. A., Almarghalani, D. A., Boddu, S. H. S., Ali, M., Kondaka, A., Ta, D., & Shah, R. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.332129 · Cited by 15

Research progress of treating ulcerative colitis and colon cancer by using oral colon targeted drug delivery system based on polymer micelles

Li, S., Li, T., Wang, X., Rahmatulla, A., Zhao, Y., Zhang, X., Liu, Y., & Chen, Y. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2514564 · Cited by 13

Therapeutic Potential of Nanomedicine in Management of Alzheimer’s Disease and Glioma

Anwar, F., Al-Abbasi, F. A., Naqvi, S., Sheikh, R. A., Alhayyani, S., Asseri, A. H., Asar, T. O., & Kumar, V. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s405454 · Cited by 15

Application of Nanotechnology in Neural Growth Support System

Saha, D., Devi, G. N. R., Ponnusamy, S., Pandit, J., Jaiswal, S., & Bhuyan, P. K. (2022) · IEEE Mysore Sub Section International Conference (MysuruCon) · doi:10.1109/mysurucon55714.2022.9972740 · Cited by 12

Functionalizing tetrahedral framework nucleic acids-based nanostructures for tumor in situ imaging and treatment

Hu, M., Zhang, Y., Zhang, M., Wang, Q., Cheng, W., Hou, L., Yu, Z., Yu, Z., Li, L., Zhang, X., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113982 · Cited by 12

Advanced nanotheranostic approaches for targeted glioblastoma treatment: a synergistic fusion of CRISPR-Cas gene editing, AI-driven tumor profiling, and BBB-modulation

Patil, C., Priyanka, R., Harshitha, B., Oshik, S., Yashwanth, S., Darshan, B., Patil, S., Prajwal, K. A., Naik, P., Prakash Goudanavar, S. O. P., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-02944-6 · Cited by 12

One-pot synthesis of compact DNA silica particles for gene delivery and extraordinary DNA preservation

Ramos‐Valle, A., Marín‐Caba, L., García‐Hevia, L., Correa‐Duarte, M. A., & Fanárraga, M. L. (2023) · Materials Today Advances · doi:10.1016/j.mtadv.2023.100357 · Cited by 11

Nanodrug delivery systems for regulating microglial polarization in ischemic stroke treatment: A review

Lei, S.-Y., Yang, Y.-Q., Liu, J., Zhang, D., Qu, Y., Sun, Y., Zhu, H.-J., Zhou, S., Yang, Y., & Guo, Z. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241237052 · Cited by 11

Layered Double Hydroxide Nanomaterials: Biomedical Applications, Current Status and Challenges

Sharma, R., Bhawna, Kumar, S., Singh, P., Gupta, A., & Kumar, V. (2021) · Nano LIFE · doi:10.1142/s1793984421300089 · Cited by 11

Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases

Ramasubramanian, B., Reddy, V. S., Chellappan, V., & Ramakrishna, S. (2022) · Biosensors · doi:10.3390/bios12121176 · Cited by 13

Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer

Hung, C., Wang, Y., Guo, J., Yang, R., Lee, C., Shen, M., Huang, C., Huang, C., Yang, J., & Liu, C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10871 · Cited by 11

Cas13b-mediated RNA targeted therapy alleviates genetic dilated cardiomyopathy in mice

Li, J., He, X., Kuang, X., Li, Y., Lian, H., & Nie, Y. (2024) · Cell & Bioscience · doi:10.1186/s13578-023-01143-y · Cited by 10

Integrated Role of Nanotechnology and Pharmacogenetics in Diagnosis and Treatment of Diseases

Chawla, R., Rani, V., Mishra, M., & Kumar, K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97643 · Cited by 11

pH-sensitive, tail-modified, ester-linked ionizable cationic lipids for gene delivery

Zou, Y., Zhen, Y., Zhao, Y., Chen, H., Wang, R., Wang, W., Ma, P., Zhi, D., Ju, B., & Zhang, S. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212984 · Cited by 10

Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury

Wang, X., Zhang, S., Zhang, Z., Zu, J., Shi, H., Yu, L., Lv, B., Cui, L., Mao, W., Wu, D., et al. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51837 · Cited by 10

Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level

Hoang, M., Vandamme, M., Kratassiouk, G., Pinna, G., Gravel, E., & Doris, E. (2019) · Nanoscale Advances · doi:10.1039/c9na00571d · Cited by 10

Biomimetic nanocomplexes orchestrate post-stroke cerebral microenvironment via microglia-targeted siRNA delivery

Wu, Q., Zhou, Y., Yan, J., Li, X. J., Meng, F., Wang, B., & Yin, L. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102444 · Cited by 9

Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke: From Blood-Brain Barrier Crossing to Neuroprotection

He, Y., Qu, M., Yu, L., Lu, Y., Hong, J., Sun, M., Yang, H., Mi, W., Guo, H., & Ma, Y. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s588499 · Cited by 11

Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer’s disease and Parkinson’s disease

Li, Y., Zhang, J., Ma, B., Yu, W., Xu, M., Luan, W., Yu, Q., Zhang, L., Rong, R., Fu, Y., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124786 · Cited by 10

Engineered rare-earth nanomaterials for fluorescence imaging and therapy

Wang, H., Wei, Z., Zhao, Y., Wang, S., Cao, L., Wang, F., Liu, K., & Sun, Y. (2023) · RSC Advances · doi:10.1039/d3ra02503a · Cited by 7

InN@In2S3 Core-Shell nanorod for oxygen-free and penetration depth-unrestricted photodynamic therapy against glioblastoma

Liu, B., Lan, Y., Tao, Y., Tang, X., Zhang, C., Zuo, B., Li, X., Qu, Y., Wang, Z., Zhong, X., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147386 · Cited by 7

Lanthanides and their complexes/nanoparticles: A review of cancer diagnosis, therapeutics, toxicity considerations, and clinical trials

Madanhire, T., Coetzee, L.-C. C., Adeyinka, A. S., Horne, T. K., Rashamuse, T. J., & Magwa, N. P. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106561 · Cited by 6

Ultrasound‐Assisted H 2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Zhan, R., Yan, F., Lou, C.-Y., Chen, N., Mo, X., Jiao, B., Liu, M., Zhao, Y., Xu, W., Xu, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202414397 · Cited by 6

Nanotechnology and Early Human Development

Nobile, S., & Nobile, L. (2020) · Applied Sciences · doi:10.3390/app10124323 · Cited by 6

Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen

Ferrario, C. M., Groban, L., Wang, H., & Ahmad, S. (2021) · Clinical Science · doi:10.1042/cs20210163 · Cited by 6

Breaking through barrier: The emerging role of nucleic acids-based drug delivery in stroke

Yin, G., Zheng, Y., Li, M., Wu, G., & Luo, Y. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101436 · Cited by 5

Lipid and polymeric nanocarriers for siRNA delivery to the brain

Koirala, S., & Cheng, K. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114286 · Cited by 9

Non-cationic carriers for siRNA delivery: Current progress and potential applications

Fan, M., Yang, X., Liu, Y., Xia, X., Ismail, M., & Zheng, M. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114362 · Cited by 5

Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy

Chen, L., Zhang, Z., Liu, Y., Liu, C., Xiao, C., Gong, L., Jin, M., Gao, Z., & Huang, W. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110228 · Cited by 6

Nano–bio interactions: understanding their dynamic connections

Habeeb, M., Vengateswaran, H. T., Kumbhar, S. T., You, H. W., Asane, G. S., & Aher, K. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22044-9.00025-5 · Cited by 5

Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors

Liu, R., Zhou, J., Chen, X., Zhang, J., Chen, Q., Liu, X., & Yao, K. (2024) · Biomedicines · doi:10.3390/biomedicines13010047 · Cited by 6

High-gravity technology intensified Knoevenagel condensation-Michael addition polymerization of poly (ethylene glycol)-poly (n-butyl cyanoacrylate) for blood-brain barrier delivery

Liu, X., Fu, C., Wang, M., Wang, J., Zou, H., Le, Y., & Chen, J. (2021) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2021.05.005 · Cited by 5

Molecular Modeling of Shockwave-Mediated Blood-Brain Barrier Opening for Targeted Drug Delivery

Zhou, M., Zhou, W., Yang, H. W., Cao, L., Li, M., Yin, P., & Zhou, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c00812 · Cited by 5

Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions

Satyanarayanan, S. K., Han, Z., Xiao, J., Yuan, Q., Yung, W., Ke, Y., Chang, R. C., Zhu, M. H., Su, H., Su, K. P., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.007 · Cited by 5

The Advances of Biomacromolecule-based Nanomedicine in Brain Disease

Weng, Y., & Huang, Y. (2019) · Springer eBooks · doi:10.1007/978-981-13-8731-9_7 · Cited by 5

Enhancing Gene Therapy through Ultradeformable Vesicles for Efficient siRNA Delivery

Aundhia, C. J., Shah, N. V., Talele, C., Zanwar, A. S., Kumari, M., & Patil, S. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385271654231215064542 · Cited by 4

Phytochemicals in Life Style Associated Human Diseases

Verma, H., Gangwar, P., Yadav, A., Yadav, B., Rao, R., Kumari, S., Kaur, S., Dhiman, M., & Mantha, A. K. (2025) · Advances in Science, Technology & Innovation/Advances in science, technology & innovation · doi:10.1007/978-3-031-80973-6_19 · Cited by 3

In vivo self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease

Wu, J., Guo, J., Wu, J., Song, J., Xu, J., Lin, Y., Huang, C., Shi, C., Li, J., Li, C., et al. (2025) · Brain · doi:10.1093/brain/awaf330 · Cited by 5

Engineering small extracellular vesicles: Unlocking the brain’s secret passage for central nervous system therapies

Zhou, J., Pu, Y., Ren, X., Li, L., Chen, Z., Lo, E. H., & Li, W. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251348816 · Cited by 3

Multi-enzyme active CeVO4 nanocubes targetedly reverse apoptosis in AD neurons: Dual pathway mechanism of mitochondrial homeostasis reconstruction and oxidative stress regulation

Cai, Q., Yang, Y., Yang, Y., Zhou, Y., Liu, Y., PeiyaoWu, Yang, F., Liu, J., & Liu, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168781 · Cited by 3

Glioblastoma - Current Evidence

Agrawal, A., & Kunwar, D. S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100846 · Cited by 3

Drug Delivery Approaches and Imaging Techniques for Brain Tumor

Bell, M., Rooks, C. P., & Agrahari, V. (2020) · Neuromethods · doi:10.1007/978-1-0716-1052-7_4 · Cited by 3

Potential of Lipid Based Nanodrug Carriers for Targeted Treatment of Glioblastoma: Recent Progress and Challenges Ahead

Satapathy, B. S., Barik, B., Kumar, L. A., & Biswal, S. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.108419 · Cited by 3

Advancements in siRNA delivery using nanotechnology for reproductive tract cancers: From targeting to enhancing treatment efficacy

Jangde, K. K., & Mishra, D. K. (2024) · Journal of Reproductive Healthcare and Medicine · doi:10.25259/jrhm_13_2024 · Cited by 2

Astrocytic BEST1 can serve as a target for functional recovery after ischemic stroke

Xiong, S., Sun, M., Zhang, Y., Kong, P.-R., Gan, L., Gao, L., Xu, K., Wu, H., Zhu, D., Lin, Y., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.022 · Cited by 2

Cation-free siRNA micelle knockdown of EPHA2 improves sensitivity of imatinib for osteosarcoma treatment

Wang, Y., Wang, M., Yang, J., Liang, M., Liu, H., Wang, L., Peng, A., Xiang, Y., Huang, R., 董永飞, et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162705 · Cited by 2

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease

Morales, L. C., Modi, L., Dezfouli, S. A., Rajendran, A. P., Kc, R., Kadam, V., Sipione, S., & Uludağ, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060726 · Cited by 2

Navigating into the paradigm of lactoferrin surface modified nanocarriers in the management of central nervous system disorders

Desai, A., Shah, P., & Jain, S. (2025) · Polymer Bulletin · doi:10.1007/s00289-025-05881-6 · Cited by 2

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors

Meng, Q., Benckendorff, C. M. M., Morrill, C., Zhuo, Y., Egerström, A., Cheallaigh, A. N., Derrington, S. R., Obexer, R., Ortmayer, M., Levy, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67366-4 · Cited by 2

Ultrasound-mediated blood-brain barrier opening for targeted neurological drug delivery

Qin, Z., Wang, Z., Gao, C., Yong, X., Hua, Y., Zhou, Y., & Xie, J. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214754 · Cited by 2

Magnetic traction and molecular lock-key: Nano-intelligent nanobot overcomes glioblastoma ferroptosis resistance to activate ferroptosis-immune

Ye, P., Su, T., Wang, K., Yu, D., Chao, M., Fan, L., Wu, G., Wang, G., Gao, F., & Hua, L. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.174160 · Cited by 3

DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles

Wang, F., Li, Y., Xu, J., Tang, W., Xu, X., Lou, X., Jing, D., Fan, G., Qin, Y., Chen, J., et al. (2026) · ACS Nano · doi:10.1021/acsnano.5c21452 · Cited by 2

Nanomedicine Strategies to Ameliorate Neuroinflammation and Prevent Secondary Neural Tissue Damage

Hegab, R. A., & Peppas, N. A. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.6c00120 · Cited by 2

Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System

Jiang, T., Zheng, M., & Shi, B. (2022) · Biomaterial engineering · doi:10.1007/978-981-16-5419-0_28 · Cited by 2

How Microbubble-Enhanced Shock Waves Promote the Delivery of Lipid-siRNA across Neuronal Plasma Membrane: A Computational Study

Zhou, M., Liu, L., Zhou, W., Yang, H. W., Li, M., Yin, P., & Zhou, Y. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c07556 · Cited by 2

Exosomes as nanocarrier for Neurotherapy: Journey from application to challenges

Ale, Y., & Nainwal, N. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106312 · Cited by 2

A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain

Gilbert, B. R., Miglani, C., Karmakar, A., Pal, M., Chandran, V. C., Gupta, S., Pal, A., & Ganguli, M. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102480 · Cited by 2

siRNA polymer conjugates for the delivery of RNAi therapeutics for the treatment of Parkinson’s disease

Singh, P., Mishra, N., Singh, N., Alka, Nisha, R., Maurya, P., Pal, R. R., & Saraf, S. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00002-2 · Cited by 2

Advances in engineered smart biomaterials for cancer immunotherapy

Moghaddam, Z. S., Youseffi, M., Isreb, M., Mozafari, M., & Najafzadeh, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85661-4.00020-2 · Cited by 1

Prediction and control of the particle size of polyethylene glycol–free lipid nanoparticles using a design of experiment

Ryoko, S., Koide, H., Song, F., Yonezawa, S., Hashimoto, M., Toyota, H., Oku, N., & Asai, T. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151718 · Cited by 1

Formulation and characterization of lutein laden gel via nasal delivery: nasal permeation, and pharmacokinetic studies

Varshney, A., Rajput, A., & Pokharkar, V. (2025) · Therapeutic Delivery · doi:10.1080/20415990.2025.2598146 · Cited by 1

Structurally-defined non-cationic docosahexaenoic acid based siRNA-micelles for safe and effective combinatorial glioblastoma therapy

Xu, S., Fan, M., Ding, Q., Wang, Y., Ismail, M., Ruan, W., Zou, Y., Zhang, D., & Zheng, M. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114568 · Cited by 1

The PAH-AM-PEG-ApoE@siRNA Nanocarrier Delivery System for Polo-like Kinase 1 Inhibition Suppresses Glioma Progression

Su, F., Lu, S., Zhang, J., Zhang, Y., Zhang, Y., Cheng, L., Li, J., Li, Y., He, G., & Yin, L. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-025-03323-0 · Cited by 1

CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics

Ding, X., Chen, X., Boehm, P., Carretero‐Cerdán, A., Jang, S., Sullivan, E. E., Arokiaraj, C. M., Ristic, F., Kavvathas, B., Campos, L., et al. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02294-y · Cited by 1

Current trends, achievements, and prospects of smart nanodevices in the global pharma market

Murti, B. T., Putri, A. D., Irham, L. M., Perwitasari, D. A., Hsieh, C., Yang, P., Kanchi, S., & Sabela, M. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817923-9.00013-4 · Cited by 1

Drug delivery and in vivo absorption

Abrami, M., Grassi, L. C., Farra, R., Dapas, B., di Vittorio, R., Grassi, G., Milcovich, G., & Grassi, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85740-6.00011-x · Cited by 1

Small Interfering RNAs in Neurodegenerative Diseases: A Therapeutic Horizon

El-Nablaway, M. (2025) · Advanced Health Science and Technology Journal · doi:10.4103/ahstj.ahstj_8_25 · Cited by 1

Targeting HCN4 channels in epilepsy

Kharouf, Q. (2020) · Minerva Access (University of Melbourne) · Cited by 1

Toxicity and Safety Evaluation of Lipid‐Based Nanoparticles for Brain Delivery

Patel, M., & Patel, P. R. (2021) · Wiley eBooks · doi:10.1002/9781119769897.ch10 · Cited by 1

A combination of systemic mannitol administration and mannitol-modified polyester nanoparticles facilitate gene delivery to the brain through caveolae-mediated endocytosisPreprint

Reshma, G., Miglani, C., Karmakar, A., Gupta, S., Pal, A., & Ganguli, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.29.610249 · Cited by 1

Therapeutic Effect of Glypican-3 Gene Silencing Using siRNA for Ovarian Cancer in a Murine Peritoneal Dissemination Model

Hazekawa, M., Nishinakagawa, T., Kawakubo‐Yasukochi, T., & Nakashima, M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.90311

Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System

Jiang, T., Zheng, M., & Shi, B. (2021) · Biomaterial engineering · doi:10.1007/978-981-33-6198-0_28-1

Selenocystine-Derived Label-Free Fluorescent Schiff Base Nanocomplex for siRNA Delivery Synergistically Kills Cancer Cells

Liu, Y., Yang, H., Liu, Q., Pan, M., Wang, D., Pan, S., Zhang, W., Wei, J., Zhao, X., & Ji, J. (2022) · Molecules · doi:10.3390/molecules27041302

Gynaecological malignancies

Clifford, A., Kelly, C., Yau, C., & Hallam, S. (2012) · CRC Press eBooks · doi:10.1201/b13289-21

Detection of the characteristic magnetic signal of paclitaxel and its application in the inhibition of glioma cells

Deng, Y., Tao, Q., Tang, Q., Liu, Y., Dong, H., Shi, Z., Xie, X., Wang, W., Zhou, L., & Yu, J. (2023) · Fundamental Research · doi:10.1016/j.fmre.2022.09.036

Advancing Cancer Theranostics Through Biomimetics: A Comprehensive ReviewPreprint

Anitha, K., Chenchula, S., Vijayraj, S., Bhatt, S., Sharma, N., Lakshmi, S. M., Chikatipalli, R., & Milan, R. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4624553

Recent Advancement in the Use of Medicinal Plants in Brain Aging

Paul, S., Majhi, A., & Sardar, P. S. (2024) · Springer eBooks · doi:10.1007/978-981-99-7269-2_14

Nano-Neurosurgery: Nanoparticle-Guided Strategies

Muhammad, P., Hanif, S., Ieva, A. D., & Shi, B. (2024) · Springer eBooks · doi:10.1007/978-3-030-80662-0_44

Nanoparticle mediated gene therapy for Alzheimer’s disease

Alhajj, L., Nasidi, K. A., Ovenseri, A. C., & Halilu, E. M. (2025) · Journal of Phytomolecules and Pharmacology · doi:10.56717/jpp.2025.v04i01.040

Rational design of siRNA-based delivery systems for effective treatment of brain diseases

Lu, D., Sun, Y., Luan, Y., & He, W. (2024) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2024.100041 · Cited by 24

Lipid and polymeric nanocarriers for siRNA delivery to the brain

Koirala, S., & Cheng, K. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114286 · Cited by 9

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

Gomes, M. J., Martins, S., & Sarmento, B. F. C. C. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.001 · Cited by 59

Brain Targeting of siRNA via Intranasal Pathway

Mohanty, C., Kundu, P., & Sahoo, S. K. (2015) · Current Pharmaceutical Design · doi:10.2174/138161282131151013191737 · Cited by 5

Why does siRNA delivery still fail in neurodegenerative diseases? Biological barriers, nanocarrier engineering, and future translational directions

Erbil, G., Aykora, D., & Uzun, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12937-x