Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Renal clearance of quantum dots

Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., et al. (2015) · Nature · doi:10.1038/nature15373 · Cited by 1,795

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Schöttler, S., Becker, G., Winzen, S., Steinbach, T., Mohr, K., Landfester, K., Mailänder, V., & Wurm, F. R. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2015.330 · Cited by 1,272

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,271

Transvascular delivery of small interfering RNA to the central nervous system

Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Ouyang, J., Xie, A., Zhou, J. M., Liu, R., Wang, L., Liu, H., Kong, N., & Tao, W. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01148k · Cited by 389

Advanced drug delivery applications of layered double hydroxide

Shirin, V. K. A., Sankar, R., Johnson, A. P., Gangadharappa, H. V., & Pramod, K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.041 · Cited by 319

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Zhou, Y., Zhu, F., Liu, Y., Zheng, M., Wang, Y., Zhang, D., Anraku, Y., Zou, Y., Li, J., Wu, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc7031 · Cited by 304

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Gregory, J. V., Kadiyala, P., Doherty, R., Cadena, M., Habeel, S., Ruoslahti, E., Lowenstein, P. R., Castro, M. G., & Lahann, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19225-7 · Cited by 295

A Robust Intrinsically Green Fluorescent Poly(Amidoamine) Dendrimer for Imaging and Traceable Central Nervous System Delivery in Zebrafish

Wang, G., Zhao, X., Wu, H., Lovejoy, D. B., Zheng, M., Lee, A., Fu, L., Miao, K., An, Y., Sayyadi, N., et al. (2020) · Small · doi:10.1002/smll.202003654 · Cited by 236

Exosomes based strategies for brain drug delivery

Rehman, F. U., Liu, Y., Zheng, M., & Shi, B. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121949 · Cited by 240

Core–shell nanostructures: perspectives towards drug delivery applications

Kumar, R., Mondal, K., Panda, P. K., Kaushik, A. K., Abolhassani, R., Ahuja, R., Rubahn, H., & Mishra, Y. K. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01559h · Cited by 227

Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

Zou, Y., Sun, X., Yang, Q., Zheng, M., Shimoni, O., Ruan, W., Wang, Y., Zhang, D., Yin, J., Huang, X., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm8011 · Cited by 227

ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy

Zheng, M., Liu, Y., Wang, Y., Zhang, D., Zou, Y., Ruan, W., Yin, J., Tao, W., Park, J. B., & Shi, B. (2019) · Advanced Materials · doi:10.1002/adma.201903277 · Cited by 220

Brain Co‐Delivery of Temozolomide and Cisplatin for Combinatorial Glioblastoma Chemotherapy

Zou, Y., Wang, Y., Xu, S., Liu, Y., Yin, J., Lovejoy, D. B., Zheng, M., Liang, X., Park, J. B., Efremov, Y. M., et al. (2022) · Advanced Materials · doi:10.1002/adma.202203958 · Cited by 204

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

Erel‐Akbaba, G., de Carvalho, L. A., Tian, T., Zinter, M., Akbaba, H., Obeid, P. J., Chiocca, E. A., Weissleder, R., Kantarcı, A. G., & Tannous, B. A. (2019) · ACS Nano · doi:10.1021/acsnano.8b08177 · Cited by 208

Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine

Zou, Y., Liu, Y., Yang, Z., Zhang, D., Lu, Y., Zheng, M., Xue, X., Geng, J., Chung, R., & Shi, B. (2018) · Advanced Materials · doi:10.1002/adma.201803717 · Cited by 203

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Li, J., Zheng, M., Shimoni, O., Banks, W. A., Bush, A. I., Gamble, J. R., & Shi, B. (2021) · Advanced Science · doi:10.1002/advs.202101090 · Cited by 202

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Zou, Y., Sun, X., Wang, Y., Yan, C., Liu, Y., Li, J., Zhang, D., Zheng, M., Chung, R. S., & Shi, B. (2020) · Advanced Materials · doi:10.1002/adma.202000416 · Cited by 178

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Zhang, L., Liu, Y., Huang, H., Xie, H., Zhang, B., Xia, W., & Guo, B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114536 · Cited by 180

Biologically modified nanoparticles as theranostic bionanomaterials

Yang, J., Zhang, X., Chuang, L. I. U., Wang, Z., Deng, L., Feng, C., Tao, W., Xu, X., & Cui, W. (2020) · Progress in Materials Science · doi:10.1016/j.pmatsci.2020.100768 · Cited by 169

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

Liu, Y., Zou, Y., Feng, C., Lee, A., Yin, J., Chung, R., Park, J. B., Rizos, H., Tao, W., Zheng, M., et al. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04683 · Cited by 162

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

Li, W., Qiu, J., Li, X.-L., Aday, S., Zhang, J., Conley, G., Xu, J., Joseph, J., Lan, H., Langer, R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6889 · Cited by 160

Layered double hydroxide nanostructures and nanocomposites for biomedical applications

Yan, L., Gonca, S., Zhu, G., Zhang, W., & Chen, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01312a · Cited by 161

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Habib, S., & Singh, M. (2022) · Polymers · doi:10.3390/polym14040712 · Cited by 142

Cation‐Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy

Jiang, T., Qiao, Y., Ruan, W., Zhang, D., Yang, Q., Wang, G., Chen, Q., Zhu, F., Yin, J., Zou, Y., et al. (2021) · Advanced Materials · doi:10.1002/adma.202104779 · Cited by 116

Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers

Caprifico, A. E., Foot, P. J. S., Polycarpou, E., & Calabrese, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111013 · Cited by 113

Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy

Rehman, F. U., Liu, Y., Yang, Q., Yang, H., Liu, R., Zhang, D., Muhammad, P., Liu, Y., Hanif, S., Ismail, M., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.036 · Cited by 108

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe, B. A., & Naki, T. (2019) · Applied Sciences · doi:10.3390/app9112219 · Cited by 105

Carrier strategies boost the application of CRISPR/Cas system in gene therapy

Xu, Z., Wang, Q., Zhong, H., Jiang, Y., Shi, X., Yuan, B., Yu, N., Zhang, S., Yuan, X., Guo, S., et al. (2022) · Exploration · doi:10.1002/exp.20210081 · Cited by 105

Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function

Gao, J., Song, Q., Gu, X. Q., Jiang, G., Huang, J., Tang, Y., Yu, R., Wang, A., Huang, Y., Zheng, G., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01551-8 · Cited by 101

Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases

Samaridou, E., Walgrave, H., Salta, E., Álvarez, D. M., Castro-López, V., Loza, M. I., & Alonso, M. J. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119657 · Cited by 100

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

Azambuja, J. H., Schuh, R. S., Michels, L. R., Gelsleichter, N. E., Beckenkamp, L. R., Iser, I. C., Lenz, G. S., de Oliveira, F. H., Venturin, G. T., Greggio, S., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01730-6 · Cited by 96

A review on core–shell structured unimolecular nanoparticles for biomedical applications

Chen, G., Wang, Y., Xie, R., & Gong, S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.008 · Cited by 95

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders

O’Connell, E. M., & Lohoff, F. W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00609 · Cited by 93

The siRNAsome: A Cation‐Free and Versatile Nanostructure for siRNA and Drug Co‐delivery

Zheng, M., Jiang, T., Yang, W., Zou, Y., Wu, H., Liu, X., Zhu, F., Qian, R., Ling, D., McDonald, K. L., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201814289 · Cited by 88

Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain

Najafabadi, R. E., Kazemipour, N., Esmaeili, A., Beheshti, S., & Nazıfı, S. (2018) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-018-0249-7 · Cited by 87

RNA delivery biomaterials for the treatment of genetic and rare diseases

Zhao, W., Hou, X., Vick, O. G., & Dong, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119291 · Cited by 82

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Leandro, K., Bicker, J., Alves, G., Falcão, A. C., & Fortuna, A. C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.031 · Cited by 87

Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases

Luo, M., Lee, L. K. C., Peng, B., Choi, C. H. J., Tong, W. Y., & Voelcker, N. H. (2022) · Advanced Science · doi:10.1002/advs.202201740 · Cited by 85

Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis

Wang, G., Rayner, S. L., Chung, R. S., Shi, B., & Liang, X. J. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100055 · Cited by 87

Advances in nanomedicines for diagnosis of central nervous system disorders

Zhang, X., Zhou, J., Gu, Z., Zhang, H., Gong, Q., & Luo, K. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120492 · Cited by 80

siRNA‐based nanotherapeutics as emerging modalities for immune‐mediated diseases: A preliminary review

Sargazi, S., Arshad, R., Ghamari, R., Rahdar, A., Bakhshi, A., Fathi‐karkan, S., Ajalli, N., Bilal, M., & Diez-Pascual, A. M. (2022) · Cell Biology International · doi:10.1002/cbin.11841 · Cited by 77

Brain-targeted CRISPR/Cas9 nanomedicine for effective glioblastoma therapy

静香, 前., Jiao, M., Xu, S., Ismail, M., Xie, X., An, Y., Guo, H., Qian, R., Shi, B., & Zheng, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.046 · Cited by 78

Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma

Jin, Y., Zhang, B., Li, J., Guo, Z., Zhang, C., Chen, X., Ma, L., Wang, Z., Yang, H., Li, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr9266 · Cited by 74

Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System

Mendonça, M. C. P., Kont, A., Aburto, M. R., Cryan, J. F., & O’Driscoll, C. M. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c01238 · Cited by 75

Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3

Liang, S., Zuo, F.-F., Yin, B., & Ye, B. (2022) · Biomaterials Science · doi:10.1039/d1bm01723c · Cited by 75

Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition

Wang, Q., Liu, J., Hu, Y., Pan, T. S., Xu, Y., Yu, J., Xiong, W., Zhou, Q., & Wang, Y. (2021) · Theranostics · doi:10.7150/thno.61085 · Cited by 70

Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration

Kambhampati, S. P., Bhutto, I. A., Wu, T., Ho, K., McLeod, D. S., Lutty, G. A., & Kannan, R. M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.035 · Cited by 69

Emerging nanotherapeutics for antithrombotic treatment

Zhao, Z., Yang, F., Zhang, X., Sun, J., He, Z., & Luo, C. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120200 · Cited by 68

Nanomedicine-based immunotherapy for central nervous system disorders

Hanif, S., Muhammad, P., Chesworth, R., Rehman, F. U., Qian, R., Zheng, M., & Shi, B. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0429-z · Cited by 69

Polymeric nanoparticle mediated inhibition of miR-21 with enhanced miR-124 expression for combinatorial glioblastoma therapy

Liu, Y., Zheng, M., Jiao, M., Yan, C., Xu, S., Du, Q., Morsch, M., Yin, J., & Shi, B. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121036 · Cited by 65

Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies

Karlsson, J. E., Luly, K. M., Tzeng, S. Y., & Green, J. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113999 · Cited by 66

A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration

Tang, L., Zhang, R., Wang, Y., Zhang, X., Yang, Y., Zhao, B., & Yang, L. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.013 · Cited by 63

PEG length effect of peptide-functional liposome for blood brain barrier (BBB) penetration and brain targeting

Du, Q., Liu, Y., Fan, M., Wei, S., Ismail, M., & Zheng, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.005 · Cited by 66

Targeting materials and strategies for RNA delivery

Lin, L., Su, K., Cheng, Q., & Liu, S. (2023) · Theranostics · doi:10.7150/thno.87316 · Cited by 61

Smart Manganese Dioxide-Based Lanthanide Nanoprobes for Triple-Negative Breast Cancer Precise Gene Synergistic Chemodynamic Therapy

Ming, L., Song, L., Xu, J., Wang, R., Shi, J., Chen, M., & Zhang, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c08927 · Cited by 56

Dual‐Targeted Novel Temozolomide Nanocapsules Encapsulating siPKM2 Inhibit Aerobic Glycolysis to Sensitize Glioblastoma to Chemotherapy

Zhang, Y., Ma, H., Li, L.-S., Sun, C., Yu, C., Wang, L., Xu, D., Song, X., & Yu, R. (2024) · Advanced Materials · doi:10.1002/adma.202400502 · Cited by 57

Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues

Kohata, A., Hashim, P. K., Okuro, K., & Aida, T. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12501 · Cited by 58

IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis

Lin, W., Niu, R., Park, S., Zou, Y., Kim, S. S., Xia, X., Xing, S., Yang, Q., Sun, X., Yuan, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37306-1 · Cited by 56

Co-Delivery Of Dihydroartemisinin And HMGB1 siRNA By TAT-Modified Cationic Liposomes Through The TLR4 Signaling Pathway For Treatment Of Lupus Nephritis

Diao, L., Tao, J., Wang, Y., Hu, Y., & He, W. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s220754 · Cited by 53

Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

Channa, G. M., Hassan, D., Zeeshan, M., Ruiz-Pulido, G., Ebrahimi, N., Mobashar, A., Pourmadadi, M., Rahdar, A., Sargazi, S., Fathi‐karkan, S., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104774 · Cited by 53

Chitosan-Based Polymeric Nanoparticles as an Efficient Gene Delivery System to Cross Blood Brain Barrier: In Vitro and In Vivo Evaluations

Khan, I. N., Navaid, S., Waqar, W., Hussein, D. M., Ullah, N., Khan, M. U. A., Hussain, Z., & Javed, A. (2024) · Pharmaceuticals · doi:10.3390/ph17020169 · Cited by 50

A blood–brain barrier- and blood–brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy

Tang, L., Zhang, R., Wang, Y., Liu, M., Hu, D., Wang, Y., & Li, Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.006 · Cited by 51

Current approaches to facilitate improved drug delivery to the central nervous system

Markowicz-Piasecka, M., Darłak, P., Markiewicz, A., Sikora, J., Adla, S. K., Bagina, S., & Huttunen, K. M. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.11.003 · Cited by 50

Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders

Guo, Z.-H., Khattak, S., Rauf, M. A., Ansari, M. A., Alomary, M. N., Razak, S., Yang, C., Wu, D., & Ji, X. (2023) · Molecules · doi:10.3390/molecules28031283 · Cited by 49

Tuning the Elasticity of Polymersomes for Brain Tumor Targeting

Zheng, M., Du, Q., Wang, X., Zhou, Y., Li, J., Xia, X., Lu, Y., Yin, J., Zou, Y., Park, J. B., et al. (2021) · Advanced Science · doi:10.1002/advs.202102001 · Cited by 46

Radiation-Triggered Selenium-Engineered Mesoporous Silica Nanocapsules for RNAi Therapy in Radiotherapy-Resistant Glioblastoma

Tang, X., Wang, Z., Xie, Y., Liu, Y., Yang, K., Li, T., Shen, H., Zhao, M., Jin, J., Xiao, H., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c00269 · Cited by 47

Gint4.T-siHDGF chimera-capped mesoporous silica nanoparticles encapsulating temozolomide for synergistic glioblastoma therapy

Fei, H., Yang, J., Jiang, N., Zhou, Y., Wei, N., Liu, Y., Miao, J., Zhang, L., Li, R., Zhang, A., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122479 · Cited by 45

Cancer Nanomedicines in an Evolving Oncology Landscape

Guo, P., Huang, J., & Moses, M. A. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.08.001 · Cited by 42

A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises

Khodaverdi, K., Bakhshi, A., Mozafari, M. R., & Naghib, S. M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134962 · Cited by 45

Nanotechnology‐Based Strategies for Early Diagnosis of Central Nervous System Disorders

Hanif, S., Muhammad, P., Niu, Z., Ismail, M., Morsch, M., Zhang, X., Li, M., & Shi, B. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100008 · Cited by 44

Virus-inspired nanosystems for drug delivery

Liao, Z., Tu, L., Li, X., Liang, X., & Huo, S. (2021) · Nanoscale · doi:10.1039/d1nr05872j · Cited by 41

Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors’ Cancer Stem Cells: Current Knowledge and Future Perspectives

Abballe, L., Spinello, Z., Antonacci, C., Coppola, L., Miele, E., Catanzaro, G., & Miele, E. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020505 · Cited by 44

Nanotechnology-enabled gene delivery for cancer and other genetic diseases

Jiang, T., Gonzalez, K. M., Cordova, L. E., & Lu, J. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2200246 · Cited by 45

Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery

Hirai, Y., Ryoko, S., Song, F., Koide, H., Naofumi, F., Tomita, K., Maeda, N., Oku, N., & Asai, T. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119479 · Cited by 41

Self-assembly of poly(allylamine)/siRNA nanoparticles, their intracellular fate and siRNA delivery

Silvio, D. D., Moro, M. M., Salvador, C., Ramírez, M. D. L. Á., Cáceres‐Vélez, P. R., Ortore, M. G., Dupin, D., Andreozzi, P., & Moya, S. E. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.09.082 · Cited by 40

The Phytochemical Potential for Brain Disease Therapy and the Possible Nanodelivery Solutions for Brain Access

Liu, Y., Chen, Z., Li, A., Liu, R., Yang, H., & Xia, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.936054 · Cited by 44

Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics

Zhao, G., Zeng, Y., Cheng, W., Karkampouna, S., Papadopoulou, P., Hu, B., Zang, S., Wezenberg, E., Forn‐Cuní, G., Lopes-Bastos, B., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c14625 · Cited by 43

Intranasally administered thermosensitive gel for brain-targeted delivery of rhynchophylline to treat Parkinson’s disease

Lin, H., Xie, L., Lv, L., Chen, J., Feng, F., Liu, W., Han, L., & Liu, F. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113065 · Cited by 38

Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles

Bian, X., Yang, L., Jiang, D., Grippin, A., Ma, Y., Wu, S., Wu, L., Wang, X., Tang, Z., Tang, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48461-4 · Cited by 41

Self-Assembled DNA Nanostructure as a Carrier for Targeted siRNA Delivery in Glioma Cells

Zhou, Y., Yang, Q., Wang, F., Zhou, Z., Xu, J., Cheng, S., & Cheng, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s295598 · Cited by 37

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

Kim, T., Viard, M., Afonin, K. A., Gupta, K., Popov, M., Salotti, J., Johnson, P. F., Linder, C., Heldman, E., & Shapiro, B. A. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.02.011 · Cited by 36

Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems

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