Cited by 210RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

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Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

Zheng, Meng, Tao, Wei, Zou, Yan, Farokhzad, Omid C., Shi, Bingyang·2018·Trends in biotechnology

DOI 10.1016/j.tibtech.2018.01.006

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Abstract

Small interfering RNA (siRNA)-based gene silencing technology has demonstrated significant potential for treating brain-associated diseases. However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport. Nanotechnology offers intriguing potential for addressing these challenges in siRNA brain delivery in conjunction with chemical and biological modification strategies. In this review, we outline the challenges of systemic delivery of siRNA-based therapy for brain diseases, highlight recent advances in the development and engineering of siRNA nanomedicines for various brain diseases, and discuss our perspectives on this exciting research field for siRNA-based therapy towards more effective brain disease therapy.

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Authors: Zheng, M., Tao, W., Zou, Y., Farokhzad, O. C., & Shi, B.
Affiliations: Henan University (CN)
Brigham and Women's Hospital (US)
Corresponding author: Shi, Bingyang
ORCID: Zheng, Meng
Tao, Wei
Zou, Yan
Farokhzad, Omid C.
Shi, Bingyang
Venue: Trends in biotechnology
Publisher: Elsevier BV
Published: 2018-05
Volume: 36
Issue: 5
Pages: 562-575
ISSN: 0167-7799 (ISSN-L)
DOI: 10.1016/j.tibtech.2018.01.006
OpenAlex: W2787845337
Cited by: 210
References: 84
Citations by year: 2026: 15 · 2025: 31 · 2024: 34 · 2023: 22 · 2022: 32 · 2021: 23 · 2020: 24 · 2019: 23 · 2018: 5
FWCI: 1.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31640027, 31600809, U1604177)
Program of China 1000-Talents Plan
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: siRNA delivery, brain drug delivery, blood-brain barrier, gene silencing, brain disorders, systemic drug delivery, chemical modification, biological modification, nanocarriers, endocytosis
MeSH terms: Animals, Brain Diseases, Disease Models, Animal, Humans, Drug Delivery Systems, RNA, Small Interfering, Nanostructures, Nanomedicine, Molecular Targeted Therapy

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Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

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