The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells
Open accessAbstract
With the ultimate aim to construct a living cell, bottom-up synthetic biology strives to reconstitute cellular phenomena in vitro - disentangled from the complex environment of a cell. Recent work towards this ambitious goal has provided new insights into the mechanisms governing life. With the fast-growing library of functional modules for synthetic cells, their classification and integration become increasingly important. We discuss strategies to reverse-engineer and recombine functional parts for synthetic eukaryotes, mimicking the characteristics of nature's own prototype. Particularly, we focus on large outer compartments, complex endomembrane systems with organelles, and versatile cytoskeletons as hallmarks of eukaryotic life. Moreover, we identify microfluidics and DNA nanotechnology as two technologies that can integrate these functional modules into sophisticated multifunctional synthetic cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R.-Y., Algire, M. A., Benders, G. A., Montague, M. G., Ma, L., Moodie, M. M., et al. (2010) · Science · doi:10.1126/science.1190719 · Cited by 2,638
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,180
Design and synthesis of a minimal bacterial genome
Hutchison, C. A., Chuang, R.-Y., Noskov, V. N., Assad-Garcia, N., Deerinck, T. J., Ellisman, M. H., Gill, J., Kannan, K., Karas, B. J., Ma, L., et al. (2016) · Science · doi:10.1126/science.aad6253 · Cited by 1,500
Spontaneous motion in hierarchically assembled active matter
Sanchez, T., Chen, D. T. N., DeCamp, S. J., Heymann, M., & Dogic, Z. (2012) · Nature · doi:10.1038/nature11591 · Cited by 1,415
Arnstein, H. R. V. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80238-1 · Cited by 1,387
Angelova, M. I., & Dimitrov, D. S. (1986) · Faraday Discussions of the Chemical Society · doi:10.1039/dc9868100303 · Cited by 1,372
The energetics of genome complexity.
Lane, N., & Martin, W. (2010) · Nature · doi:10.1038/nature09486 · Cited by 1,289
Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures
Langecker, M., Arnaut, V., Martin, T. G., List, J., Renner, S., Mayer, M., Dietz, H., & Simmel, F. C. (2012) · Science · doi:10.1126/science.1225624 · Cited by 758
Artificial Cells: Synthetic Compartments with Life-like Functionality and Adaptivity
Buddingh’, B. C., & van Hest, J. C. M. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00512 · Cited by 666
Cited by
Reconstituting Natural Cell Elements in Synthetic Cells
Gaut, N. J., & Adamala, K. P. (2021) · Advanced Biology · doi:10.1002/adbi.202000188 · Cited by 92
Lyu, X., Nuhu, M., Candry, P., Wolfanger, J., Betenbaugh, M., Saldivar, A., Zuniga, C., Wang, Y., & Shrestha, S. (2024) · Journal of Industrial Microbiology and Biotechnology · doi:10.1093/jimb/kuae025 · Cited by 53
Synthetic Biology: A New Era in Hydrocarbon Bioremediation
Jiménez-Díaz, V., Pedroza-Rodríguez, A. M., Ramos-Monroy, O., & Castillo-Carvajal, L. C. (2022) · Processes · doi:10.3390/pr10040712 · Cited by 31
Chemical neural networks inside synthetic cells? A proposal for their realization and modeling
Gentili, P. L., & Stano, P. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.927110 · Cited by 29
Through the looking glass: milestones on the road towards mirroring life
Rohden, F., Hoheisel, J. D., & Wieden, H.-J. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.06.006 · Cited by 18
Metadata
- Authors
- Göpfrich, K., Platzman, I., & Spatz, J. P.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 36
- Issue
- 9
- Pages
- 938-951
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2801978547
- Cited by
- 267
- References
- 80
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells. https://app.cochat.ai/papers/10.1016/j.tibtech.2018.03.008
- The paper
- Göpfrich, K., Platzman, I., & Spatz, J. P. (2018). Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2018.03.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
