The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Technologies and Standardization in Research on Extracellular Vesicles
Open accessAbstract
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various cells into physiological fluids. EV-mediated transfer of biomolecules is a critical component of a variety of physiological and pathological processes. Potential applications of EVs in novel diagnostic and therapeutic strategies have brought increasing attention. However, EV research remains highly challenging due to the inherently complex biogenesis of EVs and their vast heterogeneity in size, composition, and origin. There is a need for the establishment of standardized methods that address EV heterogeneity and sources of pre-analytical and analytical variability in EV studies. Here, we review technologies developed for EV isolation and characterization and discuss paths toward standardization in EV research.
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Cites
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Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Self-citationExosomes as a new frontier of cancer liquid biopsy
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Exosome Processing and Characterization Approaches for Research and Technology Development
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Modern isolation and separation techniques for extracellular vesicles
Liangsupree, T., Multia, E., & Riekkola, M.-L. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2020.461773 · Cited by 512
Palanisamy, C. P., Pei, J., Alugoju, P., Anthikapalli, N. V. A., Jayaraman, S., Veeraraghavan, V. P., Gopathy, S., Roy, J. R., Janaki, C. S., Thalamati, D., et al. (2023) · Theranostics · doi:10.7150/thno.83066 · Cited by 165
Metadata
- Authors
- Gandham, S., Su, X., Wood, J., Nocera, A. L., Alli, S. C., Milane, L., Zimmerman, A., Amiji, M., & Ivanov, A. R.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 38
- Issue
- 10
- Pages
- 1066-1098
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W3036200977
- Cited by
- 494
- References
- 212
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gandham, S., Su, X., Wood, J., Nocera, A. L., Alli, S. C., Milane, L., Zimmerman, A., Amiji, M., & Ivanov, A. R. (2020). Technologies and Standardization in Research on Extracellular Vesicles. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2020.05.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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