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Proteins and bioactive peptides from algae: Insights into antioxidant, anti-hypertensive, anti-diabetic and anti-cancer activities
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“Macroalgae have traditionally been consumed in many coastal and Asian populations and can be cultivated at relatively low cost using open-water farming systems that do not require arable land, freshwater, or energy-intensive infrastructure [176,192].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [192]
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“Furthermore, research on algal bioactive peptides has been disproportionately centered on microalgae, while macroalgae (seaweeds) remain comparatively underexplored despite their long history of dietary use and favorable production characteristics [73,192].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [192]
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“Commonly, these BPs are obtained through enzymatic hydrolysis, fermentation, or chemical synthesis [77].”
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“Bioactive peptides have many applications, including antimicrobial, antihypertensive, and antioxidant activities, lipid-lowering, anti-obesity, antidiabetic, and antiaging effects, and potency on mineral binding (Leong and Chang 2024).”
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“Organisms such as algae, sponges, fungi, bacteria, etc., produce a diverse array of secondary metabolites with unique chemical structures and potent biological activities, many of which exhibit significant anticancer potential [11,12].”
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“Worth to note that the usage of different enzymes results in hydrolysates with different bioactivities (Leong & Chang, 2024).”
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“Low molecular weight peptides containing aromatic and/or hydrophobic amino acids contribute significantly to these bioactivities (Leong and Chang 2024).”
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“Meanwhile, in Canada, Australia, and New Zealand, the consumption of limited strains of microalgae, including Spirulina and Chlorella , has been approved [6,19].”
Lin, L., Yuan, W., Xiao, J., Jia, J., Xie, Y., Cai, Q., Dai, C., Li, Q., & Wang, B. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145073 · Cited by 18
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“A . platensis protein requires three different proteases for processing: alcalde, papain, and trypsin individually, along with the sequence of alcalde/papain and then pepsin/trypsin/chymotrypsin [146].”
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Marine Algae‐Derived Bioactives: A Sustainable Resource for the Food and Agriculture Industries
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“Moreover, CAP obtained from SBP markedly diminishes the synthesis and function of many proteins associated with the cell cycle, thereby inhibiting malignant cell migration and proliferation [114].”
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“Other studies have shown that this species of microalga inhibited the growth of cancer cell lines, different from those used in our work [8,21].”
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“Microalgae, especially Chlorella, are also known for their high protein contents and qualities, thus becoming a promising protein source for animal feedstock and human consumption (Sathya et al. 2021; Leong and Chang 2024).”
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“Research on natural bioactive peptides derived from algae [23], plants [21], and animal [9] protein sources, as well as those naturally produced by microorganisms [10], is constantly evolving.”
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“Marine anticancer peptides (ACPs) modulate multiple cellular and molecular pathways by inducing apoptosis, disrupting cell membranes, altering pH homeostasis, and enhancing immune responses [10].”
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“Most studies have focused on identifying peptide sequences and evaluating in vitro bioactivity (Sridhar, Inbaraj, and Chen 2021; Leong and Chang 2024; Shahidi and Saeid 2025), while systematic reviews integrating structure–activity relationships, preparation technologies, delivery systems, and food…”
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“Peptides derived from algal proteins, particularly those containing hydrophobic and aromatic amino acids, exhibit a range of biological activities [69].”
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“Macroalgae have traditionally been consumed in many coastal and Asian populations and can be cultivated at relatively low cost using open-water farming systems that do not require arable land, freshwater, or energy-intensive infrastructure [176,192].”
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Holanda, T. D. B. L., Bessa, É. F., Lima, F. E. D. S., Lopes, F. L. D. S., Martins, J. R. P., Benevídes, N. M. B., & Araújo, M. L. H. (2025) · Aquaculture International · doi:10.1007/s10499-025-01864-6 · Cited by 4
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“Moreover, its extracts contain bioactive components, including polyphenols [7], fucoidan [8], and sterols [9], which exhibit antioxidant [10], hypotensive [11], immunomodulatory [12], thyroid function-regulating [13], and antitumor [14] activities.”
Romdhani, M., Dhaouafi, J., Deracinois, B., Flahaut, C., Nedjar, N., & Balti, R. (2025) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-025-03192-8 · Cited by 4
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“6 Bioactive peptides can be derived not only from chicken, beef and fi sh, but also from plants such as beans, broccoli and Ziziphus jujuba .”
Badrunanto, B., Purba, L. D. A., Wikantyasning, E. R., Maryati, M., Prayitno, J., Hidhayati, N., Agustini, N. W. S., Munawaroh, H. S. H., Susanti, H., Kusumawaty, D., et al. (2025) · Algal Research · doi:10.1016/j.algal.2025.104341 · Cited by 3
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Su, K., Ma, J., Li, Q., ZHANG, X., & Cheng, L. (2026) · Foods · doi:10.3390/foods15050811 · Cited by 5
“Proteins and bioactive peptides, derived from sources like Chlorella sp. and Arthrospira platensis, have garnered attention for applications in nutraceuticals and pharmaceuticals [139].”
Chen, J., Lin, S., Ruan, C., Liu, L., & Yang, S. (2025) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2025.110196 · Cited by 3
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Deep learning-derived optimal annotation strategies to power the systematic mapping of peptide space
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Selective release of antioxidant peptides and minerals from fermented SC-CO2-defatted Spirulina
Liu, Y., Pallarés, N., Ferrer, E., Martínez‐Culebras, P. V., Roig, P., Castagnini, J. M., Berrada, H., & Barba, F. J. (2026) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2026.104445 · Cited by 2
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“In contrast, the anti-hypertensive effect of microalgae such as chlorella and peptides produced by them has been reported [66–68], but there are no reports that polysaccharides from microalgae confer anti-hypertensive effects.”
Yu, C., Zu, X., Liang, Y., Zhao, X., Li, Y., Wang, C., & Wang, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148954 · Cited by 1
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Marine octapeptide DLTAGLLE lowers blood pressure via endothelium-RAS-microbiota axis
Hu, X., Jiang, Y., Dai, Z., Luo, Y., & Zhao, C. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.102890 · Cited by 1
Li, Q., Su, K., Yang, C., Sun, X., Huang, J., Zhong, S., & Cheng, L. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71790 · Cited by 1
“These results are consistent with Leong and Chang (2024), who reported that low- molecular-weight peptides generally display higher biological activity, likely due to their simpler spatial structures facilitating more specific interactions with target enzymes or other biomolecules.”
Chen, M., Li, D., Zeng, W., Mu, J., Wang, S. L., & Liang, Y. (2026) · Journal of Future Foods · doi:10.1016/j.jfutfo.2026.07.001 · Cited by 1
An overview of the use of proteomics and peptidomics to characterize alternative protein foods
Banerjee, R., Nanda, P. K., Alessandroni, L., & Das, A. K. (2026) · Journal of Proteomics · doi:10.1016/j.jprot.2026.105720 · Cited by 1
Avni, D., Weissberg, O., Pintel, N., & Izraelov, L. (2026) · Marine Drugs · doi:10.3390/md24080277 · Cited by 1
“Because of their high levels of nutrients and bioactive compounds, algal vitamins have been widely studied as functional foods, nutraceuticals, and for therapeutic applications that focus on preventing or managing micronutrient deficiencies [428].”
Rational module substitution strategy to enhance ACE-inhibitory peptide activity
Liang, Q., Peng, S., Liu, Z., Wang, J., Tang, L., Zhu, C., Zhu, L., Yang, M., Li, D., & Mou, H. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146191 · Cited by 1
An Overview of the Phytochemical and Therapeutic Potential of Wrightia tinctoria
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Biological activities and health benefits of fish protein hydrolysate
Liu, Y., Sebastià, A., Calleja-Gómez, M., Castagnini, J. M., Salgado-Ramos, M., Martí-Quijal, F. J., Barba, F. J., & Pallarés, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21654-1.00009-4
From Sea to Cell: Marine Peptides as Key Players in siRNA-Mediated Cancer Therapy
Alfaray, R. I., Amalia, N., Ali, M., Supranoto, Y. T. N., Darmawan, H. E., Purnomo, A. F., Pramono, A., Taslim, N. A., Tjandrawinata, R. R., Tallei, T. E., et al. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_490
Fleurence, J. (2025) · Wiley eBooks · doi:10.1002/9781394361427.refs
Kausar, R. A., Garcia, S., Anisa, D. N., & Setiawan, A. (2025) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/adb560
Mao, M., Yu, X., Tian, G., Zhang, L., Huang, H., & Chu, Q. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5247444
The Emergence of Bioactive Peptides as Anti-diabetic Agents: A Review
Prajapati, R., Singh, R. M., Singh, V., & Katrolia, A. (2025) · Current Protein and Peptide Science · doi:10.2174/0113892037386831250806112604
Reshaping Meat Consumption: Meat Substitutes in a Sustainability Perspective
Wang, C., Yang, Z., Lin, M., Miao, S., & Guo, Z. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2577168
“Agaricus bisporus 19–40 [18] Volvariella volvacea 28–35 Brown algae 5−15 [1] Green algae 30 [1] Microalgae Chlorella 65 [37] Spirulina 65 [37] Arthrospira maxima 56–70 [24] Insect Aeolesthes holosericea 49.84 [1] Orthoptera Acheta domesticus 36.39 [32] Gryllodes sigillatus 70 [22] Lepidoptera…”
InfluentialAntidiabetic efficiency of mangrove microbiome
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Marine algae as a source of bioactive compounds: unlocking anticancer potential
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Antimicrobial Potential of Algae and Their Metabolites
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Secondary Metabolites from Macroalgae: Chemistry, Classification, and Applications
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Algae in Functional Foods: Enhancing Health Benefits Through Bioactive Components
Fatima, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-22521-4_3
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“FBPs can exert their functions through various pathways, including directly inducing tumor cell apoptosis, regulating oxidative stress, inhibiting angiogenesis, and enhancing immune surveillance [ 133 ].”
Algal Proteins, Peptide Hydrolysates, and Temperate Phyconomy
Hayes, M. (2026) · Developments in applied phycology. · doi:10.1007/978-3-032-28281-1_20
Metadata
- Authors
- Leong, Y. K., & Chang, J.-S.
- Affiliations
- Tunghai University (TW)
- Corresponding author
- Chang, Jo-Shu
- Venue
- Trends in Food Science & Technology
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 145
- Pages
- 104352
- ISSN
- 0924-2244 (ISSN-L)
- OpenAlex
- W4391649509
- Cited by
- 109
- References
- 91
- Citations by year
- 2026: 32 · 2025: 57 · 2024: 20
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Food Science & Technology (publishedVersion)
- Funders
- National Science and Technology Council
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- algal proteins, bioactive peptides, antioxidant activity, antihypertensive effect, antidiabetic activity, anticancer activity, oxidative stress, Chlorella, Spirulina platensis, red macroalgae, mycosporine-like amino acids, phycobiliproteins, protein hydrolysates, functional foods, nutraceuticals, structure-function relationship, consumer acceptance, in silico prediction
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