Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

Ondetti, M. A., Rubin, B., & Cushman, D. W. (1977) · Science · doi:10.1126/science.191908 · Cited by 1,866 · see citing works

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung, H. S., Wang, F. L., Ondetti, M. A., Sabo, E. F., & Cushman, D. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86187-2 · Cited by 746 · see citing works

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

Ferreira, S. H., Bartelt, D. C., & Greene, L. J. (1970) · Biochemistry · doi:10.1021/bi00815a005 · Cited by 515 · see citing works

A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects

Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Nakamura, Y., & Takano, T. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.767 · Cited by 508 · see citing works

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

J.P. (1971) · Toxicon · doi:10.1016/0041-0101(71)90098-5 · Cited by 480 · see citing works

Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca

Cheung, H. S., & Cushman, D. W. (1973) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(73)90352-5 · Cited by 271 · see citing works

Antihypertensive Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides to Spontaneously Hypertensive Rats

Masuda, O., Nakamura, Y., & Takano, T. (1996) · Journal of Nutrition · doi:10.1093/jn/126.12.3063 · Cited by 264 · see citing works

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243 · see citing works

Identification of Antihypertensive Peptides from Peptic Digest of Two Microalgae, Chlorella vulgaris and Spirulina platensis

Suetsuna, K., & Chen, J. (2001) · Marine Biotechnology · doi:10.1007/s10126-001-0012-7 · Cited by 219 · see citing works

Bradykinin-potentiating peptides from the venom of Agkistrodon halys. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C

Kato, H., & Suzuki, T. (1971) · Biochemistry · doi:10.1021/bi00782a007 · Cited by 162 · see citing works

Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic)

Suetsuna, K. (1998) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00036-9 · Cited by 161 · see citing works

Structures and Activity of Angiotensin-converting Enzyme Inhibitors in an α-Zein Hydrolysate

Miyoshi, S., Ishikawa, H., Kaneko, T., Fukui, F., Tanaka, H., & Maruyama, S. (1991) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1991.10870760 · Cited by 155 · see citing works

Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein

Maruyama, S., Mitachi, H., Awaya, J., Kurono, M., Tomizuka, N., & Suzuki, H. (1987) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1987.10868415 · Cited by 115 · see citing works

Potentiation of the Antihypertensive Activity of Orally Administered Ovokinin, a Vasorelaxing Peptide Derived from Ovalbumin, by Emulsification in Egg Phosphatidylcholine

Fujita, H., Sasaki, R., & Yoshikawa, M. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.2344 · Cited by 100 · see citing works

Inhibition of Angiotensin-converting Enzyme by Synthetic Peptides of Human β-Casein

Kohmura, M., Nio, N., Kubo, K., Minoshima, Y., Munekata, E., & Ariyoshi, Y. (1989) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1989.10869621 · Cited by 99 · see citing works

Isolation fromα-Zein of Thermolysin Peptides with Angiotensin I-Converting Enzyme Inhibitory Activity

Yano, S., Suzuki, K., & Funatsu, G. (1996) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60.661 · Cited by 83 · see citing works

Effects of Angiotensin I-Converting Enzyme Inhibitory Substances Derived from Indonesian Dried-salted fish on Blood Pressure of Rats

Astawan, M., Wahyuni, M., Yasuhara, T., Yamada, K., Tadokoro, T., & Maekawa, A. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.425 · Cited by 79 · see citing works

Purification and identification of angiotensin I-converting enzyme inhibitors from the red alga Porphyra yezoensis.

Suetsuna, K. (1998) · PubMed · Cited by 78 · see citing works

IDENTIFICATION OF ANGIOTENSIN I-CONVERTING ENZYME INHIBITORY PEPTIDES DERIVED FROM THE PEPTIC DIGEST OF SOYBEAN PROTEIN

Chen, J.-R., Okada, T., Muramoto, K., Suetsuna, K., & Yang, S. (2002) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2002.tb00772.x · Cited by 67 · see citing works

Blood Pressure and Cardiovascular Disease

Furberg, C. D., Psaty, B. M., & Soliman, E. Z. (2009) · doi:10.1002/9781444309768.ch13 · Cited by 49 · see citing works

Angiotensin I-Converting Enzyme Inhibitory Action of Fish Sauce.

(KAINUMA), A. O., Matsumoto, E., IWASHITA, A., Yasuhara, T., Kawamura, Y., KOIZUMI, Y., & YANAGIDA, F. (1995) · Food Science and Technology International Tokyo · doi:10.3136/fsti9596t9798.1.101 · Cited by 40 · see citing works

Separation and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides from Peptic Digest of Hizikia fusiformis Protein.

Suetsuna, K. (1998) · NIPPON SUISAN GAKKAISHI · doi:10.2331/suisan.64.862 · Cited by 39 · see citing works

Dietary prevention of stroke and its mechanisms in stroke-prone spontaneously hypertensive rats--preventive effect of dietary fibre and palmitoleic acid.

Yamori, Y., Nara, Y., Tsubouchi, T., Sogawa, Y., Ikeda, K., & Horie, R. (1986) · PubMed · Cited by 36 · see citing works

Role of renal and extrarenal reninangiotensin system in the mechanism of arterial hypertension and its sequelae

Rosenthal, J. (1993) · Steroids · doi:10.1016/0039-128x(93)90097-7 · Cited by 15 · see citing works

Biological properties of angiotensin-converting enzyme inhibitor derived from tuna muscle.

Kohama, Y., Oka, H., Matsumoto, S., Nakagawa, T., MIYAMOTO, T., MIMURA, T., Nagase, Y., Satake, M., Takane, T., & FUJITA, T. (1989) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.12.566 · Cited by 15 · see citing works

Blood pressure and cardiovascular disease: what remains to be achieved?

Franklin, S. S. (2001) · PubMed · Cited by 13 · see citing works

Angiotensin I-Converting Enzyme Inhibitors in Fish Water Soluble Protein Hydrolyzates Prepared by Bioreactor.

Wako, Y., Yumi, A. B. E., HANDA, T., & ISHIKAWA, S. (1999) · Food Science and Technology Research · doi:10.3136/fstr.5.378 · Cited by 10 · see citing works

Synthesis of 1-((S)-3-acetylthio-2-methylpropanoyl)-L-propyl-L-phenylalanine (alacepril) and one of its active metabolites, the desacetyl derivative (DU-1227).

SAWAYAMA, T., Itokawa, A., Shimada, K., Yasumasa, D. O. I., KIMURA, Y., & Nishimura, H. (1990) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.38.529 · Cited by 7 · see citing works

Blood Pressure and Cardiovascular Disease

Furberg, C. D., & Psaty, B. M. (2002) · doi:10.1002/9780470986882.ch14 · Cited by 3 · see citing works

Ongoing clinical trials in systemic hypertension

ODDOU, P., & Mann, J. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.11.2031 · Cited by 2 · see citing works

Bioactive compounds in seaweed: functional food applications and legislation

Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works

Algal Proteins: Extraction, Application, and Challenges Concerning Production

Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092 · see citing works

Structural Requirements of Angiotensin I-Converting Enzyme Inhibitory Peptides: Quantitative Structure−Activity Relationship Study of Di- and Tripeptides

Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 562 · see citing works

Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis

Je, J., Qian, Z., Byun, H., & Kim, S. (2007) · Process Biochemistry · doi:10.1016/j.procbio.2007.02.006 · Cited by 490 · see citing works

Purification and in vitro antioxidative effects of giant squid muscle peptides on free radical-mediated oxidative systems

Rajapakse, N., Mendis, E., Byun, H., & Kim, S. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.02.005 · Cited by 467 · see citing works

Risks and benefits of consuming edible seaweeds

Cherry, P., O’Hara, C., Magee, P. J., McSorley, E. M., & Allsopp, P. J. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy066 · Cited by 440 · see citing works

Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion

Kim, S.-Y., Je, J., & Kim, S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.006 · Cited by 438 · see citing works

Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw

Qian, Z., Jung, W., & Kim, S. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.04.005 · Cited by 412 · see citing works

BIOACTIVE PROTEINS, PEPTIDES, AND AMINO ACIDS FROM MACROALGAE1

Harnedy, P. A., & Fitzgerald, R. J. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.00969.x · Cited by 395 · see citing works

Antihypertensive peptides from food proteins.

Aluko, R. (2015) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022814-015520 · Cited by 284 · see citing works

Food‐Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction

Iwaniak, A., Mińkiewicz, P., & Darewicz, M. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12051 · Cited by 319 · see citing works

Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14011 · Cited by 293 · see citing works

Bio-functionalities of proteins derived from marine algae — A review

Samarakoon, K. W., & Jeon, Y. (2012) · Food Research International · doi:10.1016/j.foodres.2012.03.013 · Cited by 289 · see citing works

Antihypertensive peptides from food proteins: a review

Martínez‐Maqueda, D., Miralles, B., Recio, I., & Hernández‐Ledesma, B. (2012) · Food & Function · doi:10.1039/c2fo10192k · Cited by 281 · see citing works

Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage

Qian, Z., Jung, W., Byun, H., & Kim, S. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.08.018 · Cited by 279 · see citing works

Bioactive peptides derived from marine sources: Biological and functional properties

Cunha, S. A., & Pintado, M. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.08.017 · Cited by 261 · see citing works

Red and green macroalgae for fish and animal feed and human functional food development

García‐Vaquero, M., & Hayes, M. (2015) · Food Reviews International · doi:10.1080/87559129.2015.1041184 · Cited by 214 · see citing works

AHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides

Kumar, R., Chaudhary, K., Sharma, M., Nagpal, G., Chauhan, J. S., Singh, S., Gautam, A., & Raghava, G. P. S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1141 · Cited by 211 · see citing works

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods

Cardoso, S. M., Pereira, O. R., Seca, A. M. L., Pinto, D. C. G. A., & Silva, A. M. S. (2015) · Marine Drugs · doi:10.3390/md13116838 · Cited by 206 · see citing works

Global seaweed farming and processing in the past 20 years

Zhang, L., Liao, W., Huang, Y., Wen, Y., Chu, Y., & Zhao, C. (2022) · Food Production Processing and Nutrition · doi:10.1186/s43014-022-00103-2 · Cited by 199 · see citing works

Bioactive compounds in seaweeds: An overview of their biological properties and safety

Rengasamy, K. R. R., Mahomoodally, M. F., Aumeeruddy, M. Z., Zengin, G., Xiao, J., & Kim, D. H. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.111013 · Cited by 194 · see citing works

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

Gómez‐Guzmán, M., Rodríguez‐Nogales, A., Algieri, F., & Gálvez, J. (2018) · Marine Drugs · doi:10.3390/md16080250 · Cited by 190 · see citing works

Vegetable foods: a cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

García, M. C., Puchalska, P., Esteve, C., & Marina, M. (2013) · Talanta: The International Journal of Pure and Applied Analytical Chemistry · doi:10.1016/j.talanta.2012.12.041 · Cited by 170 · see citing works

Purification and characterisation of a new antioxidant peptide from chickpea (Cicer arietium L.) protein hydrolysates

Zhang, T., Li, Y., Miao, M., & Jiang, B. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.02.072 · Cited by 178 · see citing works

Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate

Zhao, Y., Li, B., Liu, Z., Dong, S., Zhao, X. Q., & Zeng, M. (2007) · Process Biochemistry · doi:10.1016/j.procbio.2007.08.011 · Cited by 175 · see citing works

Marine Algae-Derived Bioactive Peptides for Human Nutrition and Health

Fan, X., Bai, L., Zhu, L., Li, Y., & Zhang, X. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf502420h · Cited by 172 · see citing works

Seaweed biorefinery

Torres, M. D., Kraan, S., & Domı́nguez, H. (2019) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-019-09496-y · Cited by 172 · see citing works

Nutrient and heavy metal content of edible seaweeds in New Zealand

Smith, J., Summers, G., & Wong, R. (2010) · New Zealand Journal of Crop and Horticultural Science · doi:10.1080/01140671003619290 · Cited by 164 · see citing works

Seaweed Components as Potential Modulators of the Gut Microbiota

Shannon, E., Conlon, M. A., & Hayes, M. (2021) · Marine Drugs · doi:10.3390/md19070358 · Cited by 164 · see citing works

Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases

Collins, K., Fitzgerald, G. F., Stanton, C., & Ross, R. P. (2016) · Marine Drugs · doi:10.3390/md14030060 · Cited by 156 · see citing works

Nutritional and Antioxidant Properties of Different Brown and Red Spanish Edible Seaweeds

Cofrades, S., López‐López, I., Bravo, L., Ruíz‐Capillas, C., Bastida, S., Larrea, M. T., & Jiménez-Colmenero, F. (2010) · Food Science and Technology International · doi:10.1177/1082013210367049 · Cited by 155 · see citing works

Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications

Echave, J., Fraga‐Corral, M., García-Pérez, P., Popović‐Djordjević, J. B., Avdović, E., Radulović, M. Đ., Xiao, J., Prieto, M. A., & Simal‐Gándara, J. (2021) · Marine Drugs · doi:10.3390/md19090500 · Cited by 154 · see citing works

Basic and recent advances in marine antihypertensive peptides: Production, structure-activity relationship and bioavailability

Abdelhedi, O., & Nasri, M. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.04.002 · Cited by 153 · see citing works

Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food

De Leo, F., Panarese, S., Gallerani, R., & Ceci, L. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789271834 · Cited by 149 · see citing works

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

Rosa, G. P., Tavares, W. R., Sousa, P. M. C., Kane-Pagès, A., Seca, A. M. L., & Pinto, D. C. G. A. (2019) · Marine Drugs · doi:10.3390/md18010008 · Cited by 151 · see citing works

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

Echave, J., Otero, P., Garcia‐Oliveira, P., Munekata, P. E. S., Pateiro, M., Lorenzo, J. M., Simal‐Gándara, J., & Prieto, M. A. (2022) · Antioxidants · doi:10.3390/antiox11010176 · Cited by 143 · see citing works

Preparation and Identification of ACE Inhibitory Peptides from the Marine Macroalga Ulva intestinalis

Sun, S., Xu, X., Sun, X., Zhang, X., Chen, X., & Xu, N. (2019) · Marine Drugs · doi:10.3390/md17030179 · Cited by 140 · see citing works

Current knowledge on the extraction, purification, identification, and validation of bioactive peptides from seaweed

Cermeño, M., Kleekayai, T., Amigo‐Benavent, M., Harnedy‐Rothwell, P. A., & Fitzgerald, R. J. (2020) · Electrophoresis · doi:10.1002/elps.202000153 · Cited by 139 · see citing works

Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Phycobiliproteins of Dulse Palmaria palmata

Furuta, T., Miyabe, Y., Yasui, H., Kinoshita, Y., & Kishimura, H. (2016) · Marine Drugs · doi:10.3390/md14020032 · Cited by 130 · see citing works

A comprehensive approach to formulation of seaweed-enriched meat products: From technological development to assessment of healthy properties

Cofrades, S., Benedı́, J., Garcimartín, A., Sánchez-Muniz, F. J., & Jiménez-Colmenero, F. (2016) · Food Research International · doi:10.1016/j.foodres.2016.06.029 · Cited by 127 · see citing works

Bioactivities of the edible brown seaweed, Undaria pinnatifida: A review

Wang, L., Park, Y.-J., Jeon, Y.-J., & Ryu, B. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.06.079 · Cited by 124 · see citing works

Overview on the Antihypertensive and Anti-Obesity Effects of Secondary Metabolites from Seaweeds

Seca, A. M. L., & Pinto, D. C. G. A. (2018) · Marine Drugs · doi:10.3390/md16070237 · Cited by 123 · see citing works

Hydrolyzates from Pyropia columbina seaweed have antiplatelet aggregation, antioxidant and ACE I inhibitory peptides which maintain bioactivity after simulated gastrointestinal digestion

Cian, R. E., Garzón, A. G., Betancur‐Ancona, D., Chel‐Guerrero, L., & Drago, S. R. (2015) · LWT · doi:10.1016/j.lwt.2015.06.043 · Cited by 121 · see citing works

Fucoxanthin‐rich seaweed extract suppresses body weight gain and improves lipid metabolism in high‐fat‐fed C57BL/6J mice

Jeon, S.-M., Kim, H., Woo, M., Lee, M., Shin, Y. C., Park, Y. B., & Choi, M. (2010) · Biotechnology Journal · doi:10.1002/biot.201000215 · Cited by 115 · see citing works

Enzyme-assisted extraction of fucoxanthin and lipids containing polyunsaturated fatty acids from Undaria pinnatifida using dimethyl ether and ethanol

Billakanti, J. M., Catchpole, O. J., Fenton, T., Mitchell, K. A., & MacKenzie, A. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.09.015 · Cited by 110 · see citing works

Proteins and bioactive peptides from algae: insights into antioxidant, anti-hypertensive, anti-diabetic and anti-cancer activities

Leong, Y. K., & Chang, J.-S. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104352 · Cited by 109 · see citing works

Isolation of Two Anti-inflammatory and One Pro-inflammatory Polyunsaturated Fatty Acids from the Brown Seaweed Undaria pinnatifida

Khan, M. N. A., Cho, J., Lee, M., Kang, J.-Y., Park, N. G., Fujii, H., & Hong, Y. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071791s · Cited by 108 · see citing works

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Hamidi, M., Kozani, P. S., Kozani, P. S., Pierre, G., Michaud, P., & Delattre, C. (2019) · Marine Drugs · doi:10.3390/md18010028 · Cited by 107 · see citing works

A fluorescence-based protocol for quantifying angiotensin-converting enzyme activity

Sentandreu, M. Á., & Toldrá, F. (2006) · Nature Protocols · doi:10.1038/nprot.2006.349 · Cited by 105 · see citing works

Enzymatic modification of sesame seed protein, sourced from waste resource for nutraceutical application

Chatterjee, R., Dey, T. K., Ghosh, M., & Dhar, P. (2015) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2015.01.007 · Cited by 101 · see citing works

Seaweed proteins, peptides, and amino acids

Pangestuti, R., & Kim, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00006-4 · Cited by 99 · see citing works

Algal nutraceuticals: A perspective on metabolic diversity, current food applications, and prospects in the field of metabolomics

García-Pérez, P., Cassani, L., Garcia‐Oliveira, P., Xiao, J., Simal‐Gándara, J., Prieto, M. A., & Lucini, L. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135295 · Cited by 97 · see citing works

Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases

Pangestuti, R., & Kim, S. (2017) · Marine Drugs · doi:10.3390/md15030067 · Cited by 96 · see citing works

Marine Organisms as Potential Sources of Bioactive Peptides that Inhibit the Activity of Angiotensin I-Converting Enzyme: A Review

Pujiastuti, D. Y., Amin, M. N. G., Alamsjah, M. A., & Hsu, J. (2019) · Molecules · doi:10.3390/molecules24142541 · Cited by 94 · see citing works

Purification and identification of a novel ACE inhibitory peptide from marine alga Gracilariopsis lemaneiformis protein hydrolysate

Cao, D., Lv, X., Xu, X., Hong, Y., Sun, X. K., & Xu, N. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2886-2 · Cited by 92 · see citing works

Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice

Park, H., Lee, M., Park, Y. B., Shin, Y. C., & Choi, M. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.11.032 · Cited by 91 · see citing works

In vitro and in vivo ACE inhibitory of pistachio hydrolysates and in silico mechanism of identified peptide binding with ACE

Li, P., Jia, J., Fang, M., Zhang, L., Guo, M., Xie, J., Xia, Y., Zhou, L., & Wei, D. (2014) · Process Biochemistry · doi:10.1016/j.procbio.2014.02.007 · Cited by 91 · see citing works

Bioactive peptides from caseins released by cold active proteolytic enzymes from Arsukibacterium ikkense

Gobba, C. D., Tompa, G., & Otte, J. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.05.082 · Cited by 89 · see citing works

Purification and characterization of antioxidative peptides derived from chicken skin gelatin hydrolysate

Sarbon, N. M., Badii, F., & Howell, N. K. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.06.048 · Cited by 87 · see citing works

Impact of seaweed intake on health

Murai, U., Yamagishi, K., Kishida, R., & Iso, H. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00739-8 · Cited by 84 · see citing works

Total phenolic content and biological activities of enzymatic extracts from Sargassum muticum (Yendo) Fensholt

Puspita, M., Déniel, M., Widowati, I., Radjasa, O. K., Douzenel, P., Marty, C., Vandanjon, L., Bedoux, G., & Bourgougnon, N. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1086-6 · Cited by 83 · see citing works

Isolation and Characterization of Peptides with Antihypertensive Activity in Foodstuffs

Puchalska, P., Alegre, M. L. M., & García, M. C. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.664829 · Cited by 83 · see citing works

Macroalgal-derived protein hydrolysates and bioactive peptides: Enzymatic release and potential health enhancing properties

Pimentel, F. B., Alves, R. C., Harnedy, P. A., FitzGerald, R. J., & Oliveira, M. B. P. P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.09.006 · Cited by 81 · see citing works

Comprehensive exploration of marine algae diversity, bioactive compounds, health benefits, regulatory issues, and food and drug applications

Ahmed, N., Sheikh, M. A., Ubaid, M., Chauhan, P., Kumar, K., & Choudhary, S. (2024) · Measurement Food · doi:10.1016/j.meafoo.2024.100163 · Cited by 84 · see citing works

Purification and characterization of a nitric oxide inhibitory peptide from Ruditapes philippinarum

Lee, S., Kim, E., Kim, Y.-S., Hwang, J.-W., Lee, K. H., Choi, D., Kang, H. W., Moon, S.-H., Jeon, B.-T., & Park, P. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.021 · Cited by 80 · see citing works

Antioxidant Peptides from Protein Hydrolysate of Microalgae Navicula incerta and their Protective Effects in Hepg2/CYP2E1 Cells Induced by Ethanol

Kang, K., Qian, Z., Ryu, B., Karadeniz, F., Kim, D., & Kim, S. (2012) · Phytotherapy Research · doi:10.1002/ptr.4603 · Cited by 79 · see citing works

A Review on Nutrients, Phytochemicals, and Health Benefits of Green Seaweed, Caulerpa lentillifera

Syakilla, N., George, R., Chye, F. Y., Pindi, W., Mantihal, S., Wahab, N. A., Fadzwi, F. M., Gu, P. H., & Matanjun, P. (2022) · Foods · doi:10.3390/foods11182832 · Cited by 88 · see citing works

Evaluation of the in vitro biological activity of protein hydrolysates of the edible red alga, Palmaria palmata (dulse) harvested from the Gaspe coast and cultivated in tanks

Beaulieu, L., Sirois, M., & Tamigneaux, É. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0850-3 · Cited by 77 · see citing works

In vitro antioxidant and antibacterial properties of hydrolysed proteins of delimed tannery fleshings: comparison of acid hydrolysis and fermentation methods

Balakrishnan, B., Prasad, B., Rai, A. K., Suresh, P. V., Mahendrakar, N. S., & Narayan, B. (2010) · Biodegradation · doi:10.1007/s10532-010-9398-0 · Cited by 74 · see citing works

Current knowledge and challenges in extraction, characterization and bioactivity of seaweed protein and seaweed-derived proteins

Pliego-Cortés, H. S., Wijesekara, I., Lang, M., Bourgougnon, N., & Bedoux, G. (2019) · Advances in botanical research · doi:10.1016/bs.abr.2019.11.008 · Cited by 72 · see citing works

Identification of a novel angiotensin-I converting enzyme inhibitory peptide from ostrich egg white and studying its interactions with the enzyme

Tanzadehpanah, H., Asoodeh, A., Saberi, M. R., & Chamani, J. (2013) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2013.02.002 · Cited by 71 · see citing works

Identification and quantification of ACE-inhibiting peptides in enzymatic hydrolysates of plant proteins

Rudolph, S., Lunow, D., Kaiser, S., & Henle, T. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.12.039 · Cited by 70 · see citing works

Ala-Val-Phe and Val-Phe: ACE inhibitory peptides derived from insect protein with antihypertensive activity in spontaneously hypertensive rats

Vercruysse, L., Camp, J. V., Morel, N., Rougé, P., Herregods, G., & Smagghe, G. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.05.029 · Cited by 68 · see citing works

Marine proteins and peptides: Production, biological activities, and potential applications

Fernando, I. P. S., Jayawardena, T. U., & Wu, J. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0009 · Cited by 66 · see citing works

Antihypertensive Effect of Enzymatic Hydrolysate of Collagen and Gly-Pro in Spontaneously Hypertensive Rats

Ichimura, T., YAMANAKA, A., Otsuka, T., YAMASHITA, E., & Maruyama, S. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90197 · Cited by 66 · see citing works

Recent Research in Antihypertensive Activity of Food Protein-derived Hydrolyzates and Peptides

Saleh, A. S. M., Zhang, Q. R., & Shen, Q. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.724478 · Cited by 65 · see citing works

In vitro assessment of the multifunctional bioactive potential of Alaska pollock skin collagen following simulated gastrointestinal digestion

Guo, L., Harnedy, P. A., Zhang, L., Li, B., Zhang, Z., Hou, H., Zhao, X., & Fitzgerald, R. J. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6854 · Cited by 65 · see citing works

Measuring Angiotensin-I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan

Henda, Y. B., Labidi, A., Fruitier‐Arnaudin, I., Bridiau, N., Delatouche, R., Maugard, T., Piot, J., Sannier, F., Thiéry, V., & Bordenave-Juchereau, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403004e · Cited by 64 · see citing works

Cocoa Bean Proteins—Characterization, Changes and Modifications due to Ripening and Post-Harvest Processing

Rawel, H. M., Huschek, G., Sagu, S. T., & Homann, T. (2019) · Nutrients · doi:10.3390/nu11020428 · Cited by 63 · see citing works

Efficacy of a Novel ACE-Inhibitory Peptide from Sargassum maclurei in Hypertension and Reduction of Intracellular Endothelin-1

Zheng, Y., Zhang, Y., & San, S. (2020) · Nutrients · doi:10.3390/nu12030653 · Cited by 63 · see citing works

Seaweed intake and blood pressure levels in healthy pre-school Japanese children

Wada, K., Nakamura, K., Tamai, Y., Tsuji, M., Sahashi, Y., Watanabe, K., Ohtsuchi, S., Yamamoto, K., Ando, K., & Nagata, C. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-83 · Cited by 62 · see citing works

Anti-Oxidant and Fucoxanthin Contents of Brown Alga Ishimozuku (Sphaerotrichia divaricata) from the West Coast of Aomori, Japan

Maeda, H., Fukuda, S., Izumi, H., & Saga, N. (2018) · Marine Drugs · doi:10.3390/md16080255 · Cited by 61 · see citing works

Screening of Extracts from Marine Green and Brown Algae in Jeju for Potential Marine Angiotensin-I Converting Enzyme (ACE) Inhibitory Activity

차선희, 안긴내, 허수진, 김길남, 이기완, 송춘복, 김소미, & 전유진 (2006) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2006.35.3.307 · Cited by 60 · see citing works

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center–based Prospective (JPHC) Study

Murai, U., Yamagishi, K., Sata, M., Kokubo, Y., Saito, I., Yatsuya, H., Ishihara, J., Inoue, M., Sawada, N., Iso, H., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz231 · Cited by 60 · see citing works

Could dietary seaweed reverse the metabolic syndrome?

Teas, J., Baldeon, M. E., Chiriboga, D. E., Davis, J. R., Sarriés, A. J., & Braverman, L. E. (2009) · PubMed · Cited by 58 · see citing works

Evaluation of bioactive properties of peptide isolated from Exocoetus volitans backbone

Naqash, S. Y., & Nazeer, R. A. (2010) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2010.02443.x · Cited by 54 · see citing works

Bioactive Peptides: An Understanding from Current Screening Methodology

Nong, N. T. P., & Hsu, J. (2022) · Processes · doi:10.3390/pr10061114 · Cited by 54 · see citing works

Bioassay-guided fractionation approach for determination of protein precursors of proteolytic bioactive metabolites from macroalgae

Bondu, S., Bonnet, C., Gaubert, J., Deslandes, É., Turgeon, S. L., & Beaulieu, L. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0425-0 · Cited by 52 · see citing works

Optimization of Hydrolysis Conditions for the Production of Angiotensin-I Converting Enzyme-Inhibitory Peptides and Isolation of a Novel Peptide from Lizard Fish (Saurida elongata) Muscle Protein Hydrolysate

Wu, S., Sun, J., Tong, Z., Lan, X., Zhao, Z., & Liao, D. (2012) · Marine Drugs · doi:10.3390/md10051066 · Cited by 52 · see citing works

Screening of Extracts from Red Algae in Jeju for Potentials MarineAngiotensin - I Converting Enzyme (ACE) Inhibitory Activity

Cha, S., Lee, K.-W., & Jeon, Y. (2006) · ALGAE · doi:10.4490/algae.2006.21.3.343 · Cited by 52 · see citing works

Algae as a Potential Source of Protein: A Review on Cultivation, Harvesting, Extraction, and Applications

Ijaola, A. O., Akamo, D. O., George, T. T., Sengul, A., Adediji, M. Y., & Asmatulu, E. (2024) · Algal Research · doi:10.1016/j.algal.2023.103329 · Cited by 51 · see citing works

Purification and identification of an angiotensin I converting enzyme (ACE) inhibitory peptide from the gastrointestinal hydrolysate of the cotton leafworm, Spodoptera littoralis

Vercruysse, L., Smagghe, G. J., Matsui, T., & Camp, J. V. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.04.014 · Cited by 51 · see citing works

Angiotensin I Converting Enzyme Inhibitory Peptides Produced by Autolysis Reactions from Wheat Bran

Nogata, Y., Nagamine, T., Yanaka, M., & Ohta, H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900857w · Cited by 51 · see citing works

Understanding Macroalgae: A Comprehensive Exploration of Nutraceutical, Pharmaceutical, and Omics Dimensions

Adarshan, S., Sree, V. S. S., Muthuramalingam, P., Nambiar, K. S., Sevanan, M., Satish, L., Venkidasamy, B., Jeelani, P. G., & Shin, H. (2023) · Plants · doi:10.3390/plants13010113 · Cited by 58 · see citing works

Seaweed Flora of the European North Atlantic and Mediterranean

Pereira, L. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_6 · Cited by 50 · see citing works

Optimization of enzymatic hydrolysis parameters for antioxidant capacity of peptide from goat placenta

Teng, D., Fang, Y., Song, X., & Gao, Y. (2010) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2010.05.001 · Cited by 50 · see citing works

Food-derived bioactive peptides and their role in ameliorating hypertension and associated cardiovascular diseases

Ganguly, A., Sharma, K., & Majumder, K. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.04.001 · Cited by 49 · see citing works

Proteins extracted from seaweedUndaria pinnatifidaand their potential uses as foods and nutraceuticals

Nadeeshani, H., Hassouna, A., & Lu, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1898334 · Cited by 50 · see citing works

Algal spent biomass—A pool of applications

Guedes, A. C., Amaro, H. M., Sousa‐Pinto, I., & Malcata, F. X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64192-2.00016-0 · Cited by 49 · see citing works

Medicinal Effects of Peptides from Marine Microalgae

Kim, S., & Kang, K. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00025-9 · Cited by 47 · see citing works

わかめペプチドによる高血圧自然発症ラットの血圧降下作用

Suetsuna, K., Maekawa, K., & Chen, J.-R. (2003) · Institutional Repositories DataBase (IRDB)

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243 · see citing works

Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Wakame (Undaria pinnatifida) and Their Antihypertensive Effect in Spontaneously Hypertensive Rats

Sato, M., Hosokawa, T., Yamaguchi, T., Nakano, T., Muramoto, K., Kahara, T., Funayama, K., Kobayashi, A., & Nakano, T. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020482t · Cited by 290 · see citing works

Antihypertensive Effects of Hydrolysates of Wakame (Undaria pinnatifida) and Their Angiotensin-I-Converting Enzyme Inhibitory Activity

Sato, M., Oba, T., Yamaguchi, T., Nakano, T., Kahara, T., Funayama, K., Kobayashi, A., & Nakano, T. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000066495 · Cited by 63 · see citing works

Acute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin‐converting enzyme inhibitory activity

Tavares, T. G., Sevilla, M. A., Montero, M. J., Carrón, R., & Malcata, F. X. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100381 · Cited by 58 · see citing works