Proteins and bioactive peptides from algae: Insights into antioxidant, anti-hypertensive, anti-diabetic and anti-cancer activities

A systematic review on consumer acceptance of alternative proteins: Pulses, algae, insects, plant-based meat alternatives, and cultured meat

Onwezen, M. C., Bouwman, E. P., Reinders, M. J., & Dagevos, H. (2020) · Appetite · doi:10.1016/j.appet.2020.105058 · Cited by 1,093

Algal Proteins: Extraction, Application, and Challenges Concerning Production

Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092

Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems

Sheih, I., Wu, T., & Fang, T. J. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.02.014 · Cited by 405

Extraction of Proteins from Two Marine Macroalgae, Ulva Sp. and Gracilaria Sp., for Food Application, and Evaluating Digestibility, Amino Acid Composition and Antioxidant Properties of the Protein Concentrates

Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., & Livney, Y. D. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.047 · Cited by 269

Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

Suetsuna, K., Maekawa, K., & Chen, J.-R. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.11.004 · Cited by 249

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243

Anticancer and Antioxidant Activities of the Peptide Fraction from Algae Protein Waste

Sheih, I., Fang, T. J., Wu, T., & Lin, P.-H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903089m · Cited by 242

Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. 1

Hamann, M. T., Otto, C. S., Scheuer, P. J., & Dunbar, D. C. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo960877+ · Cited by 240

Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp

Hamann, M. T., & Scheuer, P. J. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a061 · Cited by 237

The Potential and Challenge of Microalgae as Promising Future Food Sources

Chen, C., Tang, T., Shi, Q., Zhou, Z., & Fan, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.06.016 · Cited by 229

Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata

Harnedy, P. A., O’Keeffe, M. B., & Fitzgerald, R. J. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.09.083 · Cited by 204

Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health

Ejike, C. E. C. C., Collins, S. A., Balasuriya, N., Swanson, A. K., Mason, B., & Udenigwe, C. C. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.10.026 · Cited by 193

Bioactive properties of peptides obtained by enzymatic hydrolysis from protein byproducts of Porphyra columbina

Cian, R. E., Martínez‐Augustin, O., & Drago, S. R. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.003 · Cited by 191

Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.

Suárez, Y., González, L. E., Cuadrado, A., Berciano, M., Lafarga, M., & Múñoz, A. (2003) · PubMed · Cited by 191

Identification of Bioactive Peptides with α-Amylase Inhibitory Potential from Enzymatic Protein Hydrolysates of Red Seaweed (Porphyra spp)

Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00960 · Cited by 182

Identification of anti-diabetes peptides from Spirulina platensis

Hu, S., Fan, X., Qi, P., & Zhang, X. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.024 · Cited by 150

In vitro assessment of the cardioprotective, anti-diabetic and antioxidant potential of Palmaria palmata protein hydrolysates

Harnedy, P., & Fitzgerald, R. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0017-4 · Cited by 149

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

Echave, J., Otero, P., Garcia‐Oliveira, P., Munekata, P. E. S., Pateiro, M., Lorenzo, J. M., Simal‐Gándara, J., & Prieto, M. A. (2022) · Antioxidants · doi:10.3390/antiox11010176 · Cited by 143

Preparation and Identification of ACE Inhibitory Peptides from the Marine Macroalga Ulva intestinalis

Sun, S., Xu, X., Sun, X., Zhang, X., Chen, X., & Xu, N. (2019) · Marine Drugs · doi:10.3390/md17030179 · Cited by 140

Current knowledge on the extraction, purification, identification, and validation of bioactive peptides from seaweed

Cermeño, M., Kleekayai, T., Amigo‐Benavent, M., Harnedy‐Rothwell, P. A., & Fitzgerald, R. J. (2020) · Electrophoresis · doi:10.1002/elps.202000153 · Cited by 139

Separation, antitumor activities, and encapsulation of polypeptide from Chlorella pyrenoidosa

Wang, X., & Zhang, X. (2013) · Biotechnology Progress · doi:10.1002/btpr.1725 · Cited by 133

A multi-national comparison of meat eaters' attitudes and expectations for burgers containing beef, pea or algae protein

Michel, F., Knaapila, A., Hartmann, C., & Siegrist, M. (2021) · Food Quality and Preference · doi:10.1016/j.foodqual.2021.104195 · Cited by 127

Enhancement of Protein and Pigment Content in Two Chlorella Species Cultivated on Industrial Process Water

Safafar, H., Nørregaard, P. U., Ljubić, A., Møller, P., Holdt, S. L., & Jacobsen, C. (2016) · Journal of Marine Science and Engineering · doi:10.3390/jmse4040084 · Cited by 122

Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities

Cermeño, M., Stack, J., Tobin, P. R., O’Keeffe, M. B., Harnedy, P. A., Stengel, D. B., & Fitzgerald, R. J. (2019) · Food & Function · doi:10.1039/c9fo00680j · Cited by 121

Antihypertensive Effects, Molecular Docking Study, and Isothermal Titration Calorimetry Assay of Angiotensin I-Converting Enzyme Inhibitory Peptides from Chlorella vulgaris

Xie, J., Chen, X., Wu, J., Zhang, Y., Zhou, Y., Zhang, L., Tang, Y.-J., & Wei, D. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04294 · Cited by 118

Purification and identification of novel angiotensin-I converting enzyme (ACE) inhibitory peptides from cultured marine microalgae (Nannochloropsis oculata) protein hydrolysate

Samarakoon, K. W., O-Nam, K., Ko, J.-Y., Lee, J.-H., Kang, M.-C., Kim, D., Lee, J. B., Lee, J.-S., & Jeon, Y.-J. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9994-6 · Cited by 116

Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein

Pan, S., Wang, S., Jing, L., & Yao, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.087 · Cited by 110

Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity, Antioxidant Properties, Phenolic Content and Amino Acid Profiles of Fucus spiralis L. Protein Hydrolysate Fractions

Paiva, L. S., Lima, E., Neto, A. I., & Baptista, J. (2017) · Marine Drugs · doi:10.3390/md15100311 · Cited by 106

Isolation and identification of anti‐proliferative peptides from Spirulina platensis using three‐step hydrolysis

Wang, Z., & Zhang, X. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7815 · Cited by 92

Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health

Ji, L., Qiu, S., Wang, Z., Zhao, C., Tang, B. H. J., Gao, Z., & Fan, J. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112737 · Cited by 89

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

O’Connor, J., Garcia-Vaquero, M., Meaney, S., & Tiwari, B. K. (2022) · Marine Drugs · doi:10.3390/md20050317 · Cited by 81

Preparation and identification of antioxidant peptides from protein hydrolysate of marine alga Gracilariopsis lemaneiformis

Zhang, X., Cao, D., Sun, X., Sun, S., & Xu, N. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-1746-9 · Cited by 79

Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity

Li, Y., Aiello, G., Bollati, C., Bartolomei, M., Arnoldi, A., & Lammi, C. (2020) · Nutrients · doi:10.3390/nu12030794 · Cited by 79

Protein nutritional quality, amino acid profile, anti-amylase and anti-glucosidase properties of microalgae: Inhibition and mechanisms of action through in vitro and in silico studies

Siahbalaei, R., Kavoosi, G., & Noroozi, M. (2021) · LWT · doi:10.1016/j.lwt.2021.112023 · Cited by 79

Evaluation of the in vitro biological activity of protein hydrolysates of the edible red alga, Palmaria palmata (dulse) harvested from the Gaspe coast and cultivated in tanks

Beaulieu, L., Sirois, M., & Tamigneaux, É. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0850-3 · Cited by 77

Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from Ulva rigida C. Agardh protein hydrolysate

Paiva, L., Lima, E., Isabel, A., & Baptista, J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.006 · Cited by 76

Prediction of Bioactive Peptides from Chlorella sorokiniana Proteins Using Proteomic Techniques in Combination with Bioinformatics Analyses

Tejano, L. A., Peralta, J. P., Yap, E. E. S., Panjaitan, F. C. A., & Chang, Y.-W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071786 · Cited by 75

Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells

Sannasimuthu, A., Kumaresan, V., Anilkumar, S., Pasupuleti, M., Munuswamy‐Ramanujam, G., Mala, K., Paray, B. A., Al‐Sadoon, M. K., Albeshr, M. F., & Arockiaraj, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.006 · Cited by 74

Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells

Chaves, R. P., da Silva, S. R., Neto, L. G. D. N., Carneiro, R. F., da Silva, A. L. C., Sampaio, A. H., de Sousa, B. L., Cabral, M. G., Videira, P. A., Teixeira, E. H., et al. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.116 · Cited by 68

Further studies and biological activities of macromolecular protein R-Phycoerythrin from Portieria hornemannii

Senthilkumar, N., Kurinjimalar, C., Thangam, R., Veeraperumal, S., Kavitha, G., Gunasekaran, P., & Rengasamy, R. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.08.004 · Cited by 67

Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae

Athukorala, Y., Trang, S., Kwok, C., & Yuan, Y. (2016) · Molecules · doi:10.3390/molecules21010119 · Cited by 63

Chemical and biological characterization of spirulina protein hydrolysates: Focus on ACE and DPP-IV activities modulation

Aiello, G., Li, Y., Boschin, G., Bollati, C., Arnoldi, A., & Lammi, C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103592 · Cited by 63

Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells

Chen, J., Tan, L., Li, C., Zhou, C., Hong, P., Sun, S., & Qian, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00925 · Cited by 63

Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium decorticatum

Thangam, R., Senthilkumar, D., Veeraperumal, S., Sathuvan, M., Sivasubramanian, S., Pazhanichamy, K., Gorlagunta, P. K., Kannan, S., Gunasekaran, P., Rengasamy, R., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405329e · Cited by 61

Investigation of Chlorella pyrenoidosa Protein as a Source of Novel Angiotensin I-Converting Enzyme (ACE) and Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides

Li, Y., Aiello, G., Fassi, E. M. A., Boschin, G., Bartolomei, M., Bollati, C., Roda, G., Arnoldi, A., Grazioso, G., & Lammi, C. (2021) · Nutrients · doi:10.3390/nu13051624 · Cited by 59

Novel peptides with anti-proliferation activity from the Porphyra haitanesis hydrolysate

Fan, X., Bai, L., Mao, X., & Zhang, X. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.05.018 · Cited by 58

Purification and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides and the Antihypertensive Effect of Chlorella sorokiniana Protein Hydrolysates

Lin, Y.-H., Chen, G.-W., Yeh, C., Song, H., & Tsai, J.-S. (2018) · Nutrients · doi:10.3390/nu10101397 · Cited by 57

Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth

Wang, Z., & Zhang, X. (2015) · Food & Function · doi:10.1039/c5fo01186h · Cited by 56

Antihyperglycemic and antioxidant activities of a lectin from the marine red algae, Bryothamnion seaforthii, in rats with streptozotocin-induced diabetes

Alves, M. F. D. A., Barreto, F. K. D. A., de Vasconcelos, M. A., Neto, L. G. D. N., Carneiro, R. F., da Silva, L. T., Nagano, C. S., Sampaio, A. H., & Teixeira, E. H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.238 · Cited by 55

Identification and in silico study of a novel dipeptidyl peptidase IV inhibitory peptide derived from green seaweed Ulva spp. hydrolysates

Cian, R. E., Nardo, A. E., Garzón, A. G., Añón, M. C., & Drago, S. R. (2021) · LWT · doi:10.1016/j.lwt.2021.112738 · Cited by 53

Bioassay-guided fractionation approach for determination of protein precursors of proteolytic bioactive metabolites from macroalgae

Bondu, S., Bonnet, C., Gaubert, J., Deslandes, É., Turgeon, S. L., & Beaulieu, L. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0425-0 · Cited by 52

Production of enzymatic hydrolysates with in vitro antioxidant, antihypertensive, and antidiabetic properties from proteins derived from Arthrospira platensis

Villaró, S., Jiménez-Márquez, S., Musari, E., Bermejo, R., & Lafarga, T. (2023) · Food Research International · doi:10.1016/j.foodres.2022.112270 · Cited by 50

A Systemic Review on Microalgal Peptides: Bioprocess and Sustainable Applications

Sathya, R., MubarakAli, D., MohamedSaalis, J., & Kim, J.-W. (2021) · Sustainability · doi:10.3390/su13063262 · Cited by 48

An ACE inhibitory peptide from Isochrysis zhanjiangensis exhibits antihypertensive effect via anti-inflammation and anti-apoptosis in HUVEC and hypertensive rats

Pei, Y., Cai, S., Ryu, B., Zhou, C., Hong, P., & Qian, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105061 · Cited by 46

Macroalgal protein hydrolysates from Palmaria palmata influence the ‘incretin effect’ in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion

McLaughlin, C. M., Harnedy-Rothwell, P. A., Lafferty, R. A., Sharkey, S., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., FitzGerald, R. J., & O’Harte, F. P. M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02583-3 · Cited by 45

Characterization of ACE Inhibitory Peptides Prepared from Pyropia pseudolinearis Protein

Kumagai, Y., Toji, K., Katsukura, S., Morikawa, R., Uji, T., Yasui, H., Shimizu, T., & Kishimura, H. (2021) · Marine Drugs · doi:10.3390/md19040200 · Cited by 42

Influence of Seasonal Variation on Chemical Composition and Nutritional Profiles of Macro‐ and Microalgae

Kumar, K. S., Kumari, S., Singh, K., & Kushwaha, P. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch2 · Cited by 42

Insights into the Regulation of Algal Proteins and Bioactive Peptides Using Proteomic and Transcriptomic Approaches

Beaulieu, L. (2019) · Molecules · doi:10.3390/molecules24091708 · Cited by 40

Characterisation of Bioactive Peptides from Red Alga Gracilariopsis chorda

Mune, M. A. M., Miyabe, Y., Shimizu, T., Matsui, W., Kumagai, Y., & Kishimura, H. (2023) · Marine Drugs · doi:10.3390/md21010049 · Cited by 40

Biochemical characterization and application of a novel lectin from the cyanobacterium Lyngabya confervoides MK012409 as an antiviral and anticancer agent

El‐Fakharany, E. M., Saad, M. H., Salem, M. S., & Sidkey, N. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.046 · Cited by 37

Identification of ACE inhibitory peptides from red alga Mazzaella japonica

Kumagai, Y., Kitade, Y., Kobayashi, M., Watanabe, K., Kurita, H., Takeda, H., Yasui, H., & Kishimura, H. (2020) · European Food Research and Technology · doi:10.1007/s00217-020-03567-z · Cited by 37

In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity

Liu, J., Bai, X., & Fu, P. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02732-z · Cited by 37

Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism

Zhu, Q., Chen, X., Wu, J., Zhou, Y., Yang, Q., Fang, M., Xie, J., & Wei, D. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2879-1 · Cited by 36

In Silico Analysis of Relationship between Proteins from Plastid Genome of Red Alga Palmaria sp. (Japan) and Angiotensin I Converting Enzyme Inhibitory Peptides

Kumagai, Y., Miyabe, Y., Takeda, T., Adachi, K., Yasui, H., & Kishimura, H. (2019) · Marine Drugs · doi:10.3390/md17030190 · Cited by 36

Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus

Hưng, L. Đ., & Trinh, P. T. H. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01455-0 · Cited by 36

Recent Advances in Micro and Macroalgal Processing

(2021) · Wiley eBooks · doi:10.1002/9781119542650 · Cited by 36

Identification of Bioactive Peptides from a Laminaria digitata Protein Hydrolysate Using In Silico and In Vitro Methods to Identify Angiotensin-1-Converting Enzyme (ACE-1) Inhibitory Peptides

Purcell, D., Packer, M. A., & Hayes, M. (2023) · Marine Drugs · doi:10.3390/md21020090 · Cited by 36

Anti-proliferation peptides from protein hydrolysates of Pyropia haitanensis

Mao, X., Bai, L., Fan, X., & Zhang, X. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-1037-7 · Cited by 34

Pressurized extraction of phycobiliproteins from Arthrospira platensis and evaluation of its effect on antioxidant and anticancer activities of these biomolecules

Carlos, T. A. V., Cavalcante, K. M. D. S. P., de Oliveira, F. D. C. E., Pessoa, C., de Sant’Ana, H. B., Feitosa, F. X., & Rocha, M. V. P. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-020-02358-z · Cited by 33

Consumers’ willingness-to-buy pasta with microalgae proteins–which label can promote sales?

Van der Stricht, H., Profeta, A., Hung, Y., & Verbeke, W. (2023) · Food Quality and Preference · doi:10.1016/j.foodqual.2023.104948 · Cited by 33

Free Radical Scavenging Properties and Induction of Apoptotic Effects of FA Fraction Obtained after Proteolysis of Bioactive Peptides from Microalgae Synechococcus sp. VDW

Suttisuwan, R., Phunpruch, S., Saisavoey, T., Sangtanoo, P., Thongchul, N., & Karnchanatat, A. (2019) · Food Technology and Biotechnology · doi:10.17113/ftb.57.03.19.6028 · Cited by 32

Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

McLaughlin, C. M., Sharkey, S. J., Harnedy‐Rothwell, P. A., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., Fitzgerald, R. J., & O'Harte, F. P. M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104101 · Cited by 32

OPTIMIZATION OF A NEW CULTURE MEDIUM FOR THE LARGE‐SCALE PRODUCTION OF PROTEIN‐RICH ARTHROSPIRA PLATENSIS (OSCILLATORIALES, CYANOPHYCEAE)

Gómez-Serrano, C., Guzmán, A., Lafarga, T., & Acién‐Fernández, F. G. (2020) · Journal of Phycology · doi:10.1111/jpy.13111 · Cited by 32

Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

Purcell, D., Packer, M. A., & Hayes, M. (2022) · Foods · doi:10.3390/foods11121792 · Cited by 30

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Terriente-Palacios, C., Rubiño, S., Hortos, M., Peteiro, C., & Castellari, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-25130-4 · Cited by 29

Preparation and Characterization of an Anticancer Peptide from Oriental Tonic Food Enteromorpha prolifera

Lin, X., Dong, L., Yan, Q., Dong, Y., Wang, L., & Wang, F. (2022) · Foods · doi:10.3390/foods11213507 · Cited by 26

In Silico Analysis of ACE Inhibitory Peptides from Chloroplast Proteins of Red Alga Grateloupia asiatica

Sumikawa, K., Takei, K., Kumagai, Y., Shimizu, T., Yasui, H., & Kishimura, H. (2020) · Marine Biotechnology · doi:10.1007/s10126-020-09959-2 · Cited by 25

In vitro assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate, Oscillatoria acuminate MHM-632 MK014210.1

Saad, M. H., El‐Fakharany, E. M., Salem, M. S., & Sidkey, N. M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1848632 · Cited by 25

Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells

Park, S., RYU, J., Kim, I., Choi, Y., & Nam, T. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2509 · Cited by 23

Hypoglycemic peptide‐enriched hydrolysates of Corbicula fluminea and Chlorella sorokiniana possess synergistic hypoglycemic activity through inhibiting α‐glucosidase and dipeptidyl peptidase‐4 activity

Huang, T., Liu, P., Lin, Y., & Tsai, J. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11402 · Cited by 23

First Report of Screening of Novel Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from the Red Alga Acrochaetium sp.

Windarto, S., Lee, M., Nursyam, H., & Hsu, J. (2022) · Marine Biotechnology · doi:10.1007/s10126-022-10152-w · Cited by 20

Characterization and antitumor activity of protein hydrolysates from Arthrospira platensis (Spirulina platensis) using two-step hydrolysis

Wang, Z., & Zhang, X. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0881-9 · Cited by 19

Anticancer Activity of Mannose-Specific Lectin, BPL2, from Marine Green Alga Bryopsis plumosa

Lee, J. H., Lee, S. B., Kim, H., Shin, J. M., Yoon, M., An, H. S., & Han, J. W. (2022) · Marine Drugs · doi:10.3390/md20120776 · Cited by 19

Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells

Li, P., Ying, J., Chang, Q., Zhu, W., Yang, G., Xu, T., Yi, H., Pan, R., Zhang, E., Zeng, X., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.5162 · Cited by 17

ACE-inhibitory peptides from Laminaria japonica and their potential anti-hypertensive mechanism

Wang, J., Ye, X., Su, Z., Zou, P., Pang, J., & Chen, J. (2021) · CyTA - Journal of Food · doi:10.1080/19476337.2021.1900923 · Cited by 17

Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent

Xiao, S., Lu, Z.-H., Yang, J., Shi, X., & Zheng, Y. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111516 · Cited by 16

Peridinin-chlorophyll-protein complex industry from algae: A critical review of the current advancements, hurdles, and biotechnological potential

Qiu, S., Yuan, Y., Li, X., Zhao, C., He, Y., Tang, B., Wang, W., & Fan, J. (2023) · Algal Research · doi:10.1016/j.algal.2023.103118 · Cited by 12

Characterization and exploration of biological properties of phycobiliproteins purified from Thai karstic cave cyanobacterium Nostoc sp. SW02

Suphan, S., Limrujiwat, K., Kula, K., Maneeruttanarungroj, C., Raksajit, W., & Khetkorn, W. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102826 · Cited by 12

Antioxidant activities of purified glycoprotein extracted from Codium decorticatum

Senthilkumar, D., & Jayanthi, S. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.501217 · Cited by 8

Exploring Metabolites Of Green Algae Caulerpa Spp. To Discover Putative Inhibitors Of Dpp-4, A New Antidiabetic Target Protein: Molecular Docking Compounds from Marine Green Algae

Balansa, W. (2023) · Jurnal Ilmiah PLATAX · doi:10.35800/jip.v11i2.48061 · Cited by 7

Bioactivity of Marine-Derived Peptides and Proteins: A Review

Shahidi, F., & Saeid, A. (2025) · Marine Drugs · doi:10.3390/md23040157 · Cited by 112

Bioactive Compounds from Marine Macroalgae: A Natural Defense Against Oxidative Stress-Related Diseases

Monroy-García, I. N., Torres-Romero, S., Castro-Ochoa, D., Mendoza-Acosta, A., Viveros‐Valdez, E., & Ayala-Zavala, J. F. (2025) · Stresses · doi:10.3390/stresses5010022 · Cited by 66

Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds

Eladl, S. N., Elnabawy, A. M., & Eltanahy, E. (2024) · Botanical studies · doi:10.1186/s40529-024-00434-y · Cited by 62

A review on anti-inflammatory and antioxidant peptides derived from marine organisms: Mechanism of action and therapeutic applications

Jegani, K. T., Balde, A., & Nazeer, R. A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105745 · Cited by 40

From Sea to Lab: Angiotensin I-Converting Enzyme Inhibition by Marine Peptides—Mechanisms and Applications

Jo, D., Khan, F., Park, S., Ko, S., Kim, K. W., Yang, D., Kim, J.-Y., Oh, G., Choi, G., Lee, D.-S., et al. (2024) · Marine Drugs · doi:10.3390/md22100449 · Cited by 42

Bio-functionalities of proteins derived from marine algae — A review

Samarakoon, K. W., & Jeon, Y. (2012) · Food Research International · doi:10.1016/j.foodres.2012.03.013 · Cited by 289

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

O’Connor, J., Garcia-Vaquero, M., Meaney, S., & Tiwari, B. K. (2022) · Marine Drugs · doi:10.3390/md20050317 · Cited by 81

Bioactive Proteins and Peptides from Microalgae

Stack, J., Gouic, A. V. L., & Fitzgerald, R. J. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch61 · Cited by 18

Algae-Derived Peptides as Functional Food Ingredients: Bioactivities, Processing Challenges, and Computational Design Strategies

Su, K., Ma, J., Li, Q., ZHANG, X., & Cheng, L. (2026) · Foods · doi:10.3390/foods15050811 · Cited by 5

Navigating the potential of algal peptides: health effects, market applications, and scientific challenges

Khaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4