The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Molecular clocks: when timesare a-changin'
Open accessAbstract
The molecular clock has proved to be extremely valuable in placing timescales on evolutionary events that would otherwise be difficult to date. However, debate has arisen about the considerable disparities between molecular and palaeontological or archaeological dates, and about the remarkably high mutation rates inferred in pedigree studies. We argue that these debates can be largely resolved by reference to the "time dependency of molecular rates", a recent hypothesis positing that short-term mutation rates and long-term substitution rates are related by a monotonic decline from the former to the latter. Accordingly, the extrapolation of rates across different timescales will result in invalid date estimates. We examine the impact of this hypothesis with respect to various fields, including human evolution, animal domestication and conservation genetics. We conclude that many studies involving recent divergence events will need to be reconsidered.
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Cites
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“... somewhat circular, however, because it is necessary to have a reasonable idea of what the true date might be to select a suitable calibration; (ii) If reliable ancient DNA data are available, use radiocarbon-dated sequences [9,46] to decrease the amount of extrapolation required to estimate the age of the root of…”
MethodMultiple and Ancient Origins of the Domestic Dog
Vilà, C., Savolainen, P., Maldonado, J. E., Amorim, I. R., Rice, J. E., Honeycutt, R. L., Crandall, K. A., Lundeberg, J., & Wayne, R. K. (1997) · Science · doi:10.1126/science.276.5319.1687 · Cited by 1,091
Time Dependency of Molecular Rate Estimates and Systematic Overestimation of Recent Divergence Times
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Self-citationGenetic Evidence for an East Asian Origin of Domestic Dogs
Savolainen, P., Zhang, Y.-P., Luo, J., Lundeberg, J., & Leitner, T. (2002) · Science · doi:10.1126/science.1073906 · Cited by 960
Rates of DNA sequence evolution differ between taxonomic groups.
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Cited by
Revising the human mutation rate: implications for understanding human evolution
Scally, A., & Durbin, R. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3295 · Cited by 610
The Late Pleistocene Dispersal of Modern Humans in the Americas
Goebel, T., Waters, M. R., & O'Rourke, D. H. (2008) · Science · doi:10.1126/science.1153569 · Cited by 599
Ecology and evolution of Mycobacterium tuberculosis
Gagneux, S. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2018.8 · Cited by 599
Time-dependent rates of molecular evolution
HO, S. Y. W., LANFEAR, R., BROMHAM, L., PHILLIPS, M. J., SOUBRIER, J., RODRIGO, A. G., & COOPER, A. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05178.x · Cited by 564
Self-citationRethinking Dog Domestication by Integrating Genetics, Archeology, and Biogeography
Larson, G., Karlsson, E. K., Perri, A., Webster, M. T., Ho, S. Y. W., Peters, J., Stahl, P. W., Piper, P. J., Lingaas, F., Fredholm, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203005109 · Cited by 540
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Metadata
- Authors
- HO, S., & LARSON, G.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 22
- Issue
- 2
- Pages
- 79-83
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2127358442
- Cited by
- 400
- References
- 49
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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