Cited by 690Epigenetics and DNA MethylationGenomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

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Epigenetics and aging: the targets and the marks

Fraga, Mario F., Esteller, Manel·2007·Trends in Genetics

DOI 10.1016/j.tig.2007.05.008

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Abstract

'Aging epigenetics' is an emerging field that promises exciting revelations in the near future. Here we focus on the functional and biological significance of the epigenetic alterations that accumulate during aging and are important in tumorigenesis. Paradigmatic examples are provided by the global loss of DNA methylation in aging and cancer and by the promoter hypermethylation of genes with a dual role in tumor suppression and progeria, such as the Werner syndrome (WRN) and lamin A/C genes. Another twist is provided by sirtuins, a family of NAD-dependent deacetylases that act on Lys16 of histone H4, which are emerging as a link between cellular transformation and lifespan.

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Association of blood cadmium levels with epigenetic age acceleration in U.S. adults aged > 50 years
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Basic Epigenetic Mechanisms of Aging
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An accurate aging clock developed from the largest dataset of microbial and human gene expression reveals molecular mechanisms of agingPreprint
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The concept of ageing in evolutionary algorithms: Discussion and inspirations for human ageing
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“However, more recently and particularly in the last decade, it has become apparent that sweeping changes occur to the epigenome through adulthood and into old age (Fraga and Esteller 2007; Horvath 2013; McClay et al. 2014; Benayoun et al. 2015).”
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A simple, rapid, interpretable, actionable and implementable digital PCR based mortality index
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Reproductive characteristics modify the association between global DNA methylation and breast cancer risk in a population-based sample of women
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Authors: Fraga, M. F., & Esteller, M.
Affiliations: Spanish National Cancer Research Centre (ES)
Corresponding author: Esteller, Manel
ORCID: Fraga, Mario F.
Esteller, Manel
Venue: Trends in Genetics
Publisher: Elsevier BV
Published: 2007-08
Volume: 23
Issue: 8
Pages: 413-418
ISSN: 0168-9525 (ISSN-L)
DOI: 10.1016/j.tig.2007.05.008
OpenAlex: W1990916340
Cited by: 690
References: 75
Citations by year: 2026: 11 · 2025: 23 · 2024: 19 · 2023: 31 · 2022: 29 · 2021: 30 · 2020: 49 · 2019: 52 · 2018: 43 · 2017: 30 · 2016: 32 · 2015: 46 · 2014: 43 · 2013: 48 · 2012: 47
FWCI: 3.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: DNA methylation loss, promoter hypermethylation, tumor suppression genes, Hutchinson-Gilford progeria syndrome, Werner syndrome, lamin A/C, sirtuins, cell transformation, lifespan, carcinogenesis
MeSH terms: Animals, Histones, Humans, Models, Biological, Cellular Senescence, DNA Methylation, Gene Silencing, Epigenesis, Genetic

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Epigenetics and aging: the targets and the marks

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