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Cited by 690Epigenetics and DNA MethylationGenomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

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Epigenetics and aging: the targets and the marks

Fraga, Mario F., Esteller, Manel·2007·Trends in Genetics
DOI 10.1016/j.tig.2007.05.008
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Abstract

'Aging epigenetics' is an emerging field that promises exciting revelations in the near future. Here we focus on the functional and biological significance of the epigenetic alterations that accumulate during aging and are important in tumorigenesis. Paradigmatic examples are provided by the global loss of DNA methylation in aging and cancer and by the promoter hypermethylation of genes with a dual role in tumor suppression and progeria, such as the Werner syndrome (WRN) and lamin A/C genes. Another twist is provided by sirtuins, a family of NAD-dependent deacetylases that act on Lys16 of histone H4, which are emerging as a link between cellular transformation and lifespan.

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Research works printed but not linked: 66

  1. Jones, 2002, The fundamental role of epigenetic events in cancer, Nat. Rev. Genet., 3, 415, 10.1038/nrg816 · DOI · Paper page
  2. Bjornsson, 2004, An integrated epigenetic and genetic approach to common human disease, Trends Genet., 20, 350, 10.1016/j.tig.2004.06.009 · DOI · Paper page
  3. Esteller, 2002, CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future, Oncogene, 21, 5427, 10.1038/sj.onc.1205600 · DOI
  4. Wilson, 1983, DNA methylation decreases in aging but not in immortal cells, Science, 220, 1055, 10.1126/science.6844925 · DOI
  5. Issa, 2003, Age-related epigenetic changes and the immune system, Clin. Immunol., 109, 103, 10.1016/S1521-6616(03)00203-1 · DOI
  6. Jenuwein, 2001, Translating the histone code, Science, 293, 1074, 10.1126/science.1063127 · DOI · Paper page
  7. Petronis, 2006, Epigenetics and twins: three variations on the theme, Trends Genet., 22, 347, 10.1016/j.tig.2006.04.010 · DOI
  8. Simmons, 2005, Developmental origins of adult metabolic disease: concepts and controversies, Trends Endocrinol. Metab., 16, 390, 10.1016/j.tem.2005.08.004 · DOI
  9. Lillycrop, 2005, Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring, J. Nutr., 135, 1382, 10.1093/jn/135.6.1382 · DOI
  10. Wong, 2005, Phenotypic differences in genetically identical organisms: the epigenetic perspective, Hum. Mol. Genet., 14, R11, 10.1093/hmg/ddi116 · DOI
  11. Flanagan, 2006, Intra- and interindividual epigenetic variation in human germ cells, Am. J. Hum. Genet., 79, 67, 10.1086/504729 · DOI
  12. Feil, 2006, Environmental and nutritional effects on the epigenetic regulation of genes, Mutat. Res., 600, 46, 10.1016/j.mrfmmm.2006.05.029 · DOI
  13. Casillas, 2003, Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts, Mol. Cell. Biochem., 252, 33, 10.1023/A:1025548623524 · DOI
  14. Esteller, 2003, Relevance of DNA methylation in the management of cancer, Lancet Oncol., 4, 351, 10.1016/S1470-2045(03)01115-X · DOI
  15. Oakes, 2003, Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats, Proc. Natl. Acad. Sci. U. S. A., 100, 1775, 10.1073/pnas.0437971100 · DOI
  16. da Silva, 2000, Quantitative evaluation of the rRNA in Alzheimer's disease, Mech. Ageing Dev., 120, 57, 10.1016/S0047-6374(00)00180-9 · DOI
  17. So, 2006, Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia, Cancer Sci., 97, 1155, 10.1111/j.1349-7006.2006.00302.x · DOI
  18. Bornman, 2001, Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals, Am. J. Pathol., 159, 831, 10.1016/S0002-9440(10)61758-0 · DOI
  19. Choi, 1996, Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver, Mutat. Res., 354, 123, 10.1016/0027-5107(96)00056-5 · DOI
  20. Takatsu, 1999, Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament, Mech. Ageing Dev., 110, 37, 10.1016/S0047-6374(99)00041-X · DOI
  21. Agrelo, 2005, Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma, J. Clin. Oncol., 23, 3940, 10.1200/JCO.2005.11.650 · DOI
  22. Taddei, 2004, The function of nuclear architecture: a genetic approach, Annu. Rev. Genet., 38, 305, 10.1146/annurev.genet.37.110801.142705 · DOI
  23. Broers, 2004, Laminopathies, J. Pathol., 204, 478, 10.1002/path.1655 · DOI
  24. Parise, 2006, Lap2alpha expression is controlled by E2F and deregulated in various human tumors, Cell Cycle, 5, 1331, 10.4161/cc.5.12.2833 · DOI
  25. Brosh, 2002, Roles of the Werner syndrome protein in pathways required for maintenance of genome stability, Exp. Gerontol., 37, 491, 10.1016/S0531-5565(01)00227-3 · DOI
  26. Kitao, 1998, Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes, Genomics, 54, 443, 10.1006/geno.1998.5595 · DOI
  27. Ellis, 1996, Molecular genetics of Bloom's syndrome, Hum. Mol. Genet., 5, 1457, 10.1093/hmg/5.Supplement_1.1457 · DOI
  28. Opresko, 2003, Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process, Carcinogenesis, 24, 791, 10.1093/carcin/bgg034 · DOI
  29. Nagy, 2004, Highly penetrant hereditary cancer syndromes, Oncogene, 23, 6445, 10.1038/sj.onc.1207714 · DOI
  30. Biron, 2004, Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development, Dev. Biol., 276, 337, 10.1016/j.ydbio.2004.08.038 · DOI
  31. Prokocimer, 2006, The nuclear lamina and its proposed roles in tumorigenesis: projection on the hematologic malignancies and future targeted therapy, J. Struct. Biol., 155, 351, 10.1016/j.jsb.2006.02.016 · DOI
  32. Sarg, 2002, Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging, J. Biol. Chem., 277, 39195, 10.1074/jbc.M205166200 · DOI
  33. Olins, 2005, Granulocyte heterochromatin: defining the epigenome, BMC Cell Biol., 6, 39, 10.1186/1471-2121-6-39 · DOI
  34. Fraga, 2005, Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer, Nat. Genet., 37, 391, 10.1038/ng1531 · DOI
  35. Pogribny, 2006, Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats, Carcinogenesis, 27, 1180, 10.1093/carcin/bgi364 · DOI
  36. Tryndyak, 2006, Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins, Cancer Biol. Ther., 5, 65, 10.4161/cbt.5.1.2288 · DOI
  37. Tryndyak, 2006, Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis, Carcinogenesis, 27, 1713, 10.1093/carcin/bgl050 · DOI
  38. Isaac, 2006, The retinoblastoma protein regulates pericentric heterochromatin, Mol. Cell. Biol., 26, 3659, 10.1128/MCB.26.9.3659-3671.2006 · DOI · Paper page
  39. Siddiqui, 2007, Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics, J. Cell. Physiol., 211, 131, 10.1002/jcp.20913 · DOI · Paper page
  40. Shumaker, 2006, Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging, Proc. Natl. Acad. Sci. U. S. A., 103, 8703, 10.1073/pnas.0602569103 · DOI · Paper page
  41. Broers, 2005, Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization, Exp. Cell Res., 304, 582, 10.1016/j.yexcr.2004.11.020 · DOI
  42. Cadinanos, 2005, From immature lamin to premature aging: molecular pathways and therapeutic opportunities, Cell Cycle, 4, 1732, 10.4161/cc.4.12.2202 · DOI
  43. Espada, 2004, Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern, J. Biol. Chem., 279, 37175, 10.1074/jbc.M404842200 · DOI
  44. Chen, 2005, Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses, Cell, 123, 437, 10.1016/j.cell.2005.08.011 · DOI
  45. Kuzmichev, 2005, Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation, Proc. Natl. Acad. Sci. U. S. A., 102, 1859, 10.1073/pnas.0409875102 · DOI
  46. Ozdag, 2006, Differential expression of selected histone modifier genes in human solid cancers, BMC Genomics, 7, 90, 10.1186/1471-2164-7-90 · DOI
  47. Sasaki, 2006, Progressive loss of SIRT1 with cell cycle withdrawal, Aging Cell, 5, 413, 10.1111/j.1474-9726.2006.00235.x · DOI
  48. Sommer, 2006, DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse, Cell Cycle, 5, 2005, 10.4161/cc.5.17.3194 · DOI
  49. Vaquero, 2004, Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin, Mol. Cell, 16, 93, 10.1016/j.molcel.2004.08.031 · DOI · Paper page
  50. Vaquero, 2006, SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis, Genes Dev., 20, 1256, 10.1101/gad.1412706 · DOI
  51. Bradbury, 2005, Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors, Leukemia, 19, 1751, 10.1038/sj.leu.2403910 · DOI
  52. Seligson, 2005, Global histone modification patterns predict risk of prostate cancer recurrence, Nature, 435, 1262, 10.1038/nature03672 · DOI
  53. Fraga, 2005, Towards the human cancer epigenome: a first draft of histone modifications, Cell Cycle, 4, 1377, 10.4161/cc.4.10.2113 · DOI
  54. Vaziri, 2001, hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase, Cell, 107, 149, 10.1016/S0092-8674(01)00527-X · DOI
  55. Dai, 2006, SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity, J. Cell. Physiol., 210, 161, 10.1002/jcp.20831 · DOI
  56. North, 2003, The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase, Mol. Cell, 11, 437, 10.1016/S1097-2765(03)00038-8 · DOI
  57. Dryden, 2003, Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle, Mol. Cell. Biol., 23, 3173, 10.1128/MCB.23.9.3173-3185.2003 · DOI
  58. Turner, 1989, Specific antibodies reveal ordered and cell-cycle-related use of histone-H4 acetylation sites in mammalian cells, Eur. J. Biochem., 179, 131, 10.1111/j.1432-1033.1989.tb14530.x · DOI
  59. Shogren-Knaak, 2006, Histone H4-K16 acetylation controls chromatin structure and protein interactions, Science, 311, 844, 10.1126/science.1124000 · DOI
  60. Gupta, 2005, Involvement of human MOF in ATM function, Mol. Cell. Biol., 25, 5292, 10.1128/MCB.25.12.5292-5305.2005 · DOI
  61. Taipale, 2005, hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells, Mol. Cell. Biol., 25, 6798, 10.1128/MCB.25.15.6798-6810.2005 · DOI
  62. Smith, 2005, A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16, Mol. Cell. Biol., 25, 9175, 10.1128/MCB.25.21.9175-9188.2005 · DOI
  63. Hiratsuka, 2003, Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene, Biochem. Biophys. Res. Commun., 309, 558, 10.1016/j.bbrc.2003.08.029 · DOI
  64. Inoue, 2006, SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress, Oncogene, 26, 945, 10.1038/sj.onc.1209857 · DOI
  65. Ershler, 1997, Aging and cancer: issues of basic and clinical science, J. Natl. Cancer Inst., 89, 1489, 10.1093/jnci/89.20.1489 · DOI
  66. Eckhardt, 2006, DNA methylation profiling of human chromosomes 6, 20 and 22, Nat. Genet., 38, 1378, 10.1038/ng1909 · DOI

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Metadata

Authors
Fraga, M. F., & Esteller, M.
Affiliations
Spanish National Cancer Research Centre (ES)
Corresponding author
Esteller, Manel
ORCID
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2007-08
Volume
23
Issue
8
Pages
413-418
ISSN
0168-9525 (ISSN-L)
DOI
10.1016/j.tig.2007.05.008
OpenAlex
W1990916340
Cited by
690
References
75
Citations by year
2026: 11 · 2025: 23 · 2024: 19 · 2023: 31 · 2022: 29 · 2021: 30 · 2020: 49 · 2019: 52 · 2018: 43 · 2017: 30 · 2016: 32 · 2015: 46 · 2014: 43 · 2013: 48 · 2012: 47
FWCI
3.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords
DNA methylation loss, promoter hypermethylation, tumor suppression genes, Hutchinson-Gilford progeria syndrome, Werner syndrome, lamin A/C, sirtuins, cell transformation, lifespan, carcinogenesis
MeSH terms
Animals, Histones, Humans, Models, Biological, Cellular Senescence, DNA Methylation, Gene Silencing, Epigenesis, Genetic

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