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Cited by 690Epigenetics and DNA MethylationGenomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

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Epigenetics and aging: the targets and the marks

Fraga, Mario F., Esteller, Manel·2007·Trends in Genetics
DOI 10.1016/j.tig.2007.05.008
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Abstract

'Aging epigenetics' is an emerging field that promises exciting revelations in the near future. Here we focus on the functional and biological significance of the epigenetic alterations that accumulate during aging and are important in tumorigenesis. Paradigmatic examples are provided by the global loss of DNA methylation in aging and cancer and by the promoter hypermethylation of genes with a dual role in tumor suppression and progeria, such as the Werner syndrome (WRN) and lamin A/C genes. Another twist is provided by sirtuins, a family of NAD-dependent deacetylases that act on Lys16 of histone H4, which are emerging as a link between cellular transformation and lifespan.

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Metadata

Authors
Fraga, M. F., & Esteller, M.
Affiliations
Spanish National Cancer Research Centre (ES)
Corresponding author
Esteller, Manel
ORCID
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2007-08
Volume
23
Issue
8
Pages
413-418
ISSN
0168-9525 (ISSN-L)
DOI
10.1016/j.tig.2007.05.008
OpenAlex
W1990916340
Cited by
690
References
75
Citations by year
2026: 11 · 2025: 23 · 2024: 19 · 2023: 31 · 2022: 29 · 2021: 30 · 2020: 49 · 2019: 52 · 2018: 43 · 2017: 30 · 2016: 32 · 2015: 46 · 2014: 43 · 2013: 48 · 2012: 47
FWCI
3.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords
DNA methylation loss, promoter hypermethylation, tumor suppression genes, Hutchinson-Gilford progeria syndrome, Werner syndrome, lamin A/C, sirtuins, cell transformation, lifespan, carcinogenesis
MeSH terms
Animals, Histones, Humans, Models, Biological, Cellular Senescence, DNA Methylation, Gene Silencing, Epigenesis, Genetic

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