The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Nonhomologous DNA end-joining for repair of DNA double-strand breaks
Open accessAbstract
phases. NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ), a nuclease (the Artemis·DNA-PKcs complex), and a ligase (XLF·XRCC4·Lig4 complex). Each of the enzymatic components is distinctive for its versatility in acting on diverse incompatible DNA end configurations coupled with a flexibility in loading order, resulting in many possible junctional outcomes from one DSB. DNA ends can either be directly ligated or, if the ends are incompatible, processed until a ligatable configuration is achieved that is often stabilized by up to 4 bp of terminal microhomology. Processing of DNA ends results in nucleotide loss or addition, explaining why DSBs repaired by NHEJ are rarely restored to their original DNA sequence. Thus, NHEJ is a single pathway with multiple enzymes at its disposal to repair DSBs, resulting in a diversity of repair outcomes.
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Cites
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882
Self-citationNon-homologous DNA end joining and alternative pathways to double-strand break repair
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Self-citationStructure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
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Self-citationSgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
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Cited by
DNA double-strand break repair-pathway choice in somatic mammalian cells
Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,457
Homologous recombination and the repair of DNA double-strand breaks
Wright, W. D., Shah, S. S., & Heyer, W.-D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000372 · Cited by 713
The molecular basis and disease relevance of non-homologous DNA end joining
Zhao, B., Rothenberg, E., Ramsden, D. A., & Lieber, M. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00297-8 · Cited by 384
Self-citationZhang, C., Chen, L., Peng, D., Jiang, A., He, Y., Zeng, Y., Xie, C., Zhou, H., Luo, X., Liu, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.017 · Cited by 331
How cells ensure correct repair of DNA double-strand breaks
Her, J., & Bunting, S. F. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000371 · Cited by 304
Metadata
- Authors
- Pannunzio, N. R., Watanabe, G., & Lieber, M. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 293
- Issue
- 27
- Pages
- 10512-10523
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2771730334
- Cited by
- 489
- References
- 122
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 792 d)
- Funders
- National Institutes of Health
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