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The p53 network: cellular and systemic DNA damage responses in cancer and aging

Vaddavalli, Pavana Lakshmi, Schumacher, Björn·2022·Trends in Genetics
DOI 10.1016/j.tig.2022.02.010
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Abstract

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most frequently mutated gene in human cancers. p53 plays a central role in responding to DNA damage and determines the outcome of the DNA damage checkpoint response by regulating cell cycle arrest and apoptosis. As a consequence of this function, dysfunctional p53 results in cells that, despite a damaged genome, continue to proliferate thus fueling malignant transformation. New insights have recently been gained into the complexity of the p53 regulation of the DNA damage response (DDR) and how it impacts a wide variety of cellular processes. In addition to cell-autonomous signaling mechanisms, non-cell-autonomous regulatory inputs influence p53 activity, which in turn can have systemic consequences on the organism. New inroads have also been made toward therapeutic targeting of p53 that for a long time has been anticipated.

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Metadata

Authors
Vaddavalli, P. L., & Schumacher, B.
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2022-06
Volume
38
Issue
6
Pages
598-612
ISSN
0168-9525 (ISSN-L)
DOI
10.1016/j.tig.2022.02.010
OpenAlex
W4221041309
Cited by
279
References
26
FWCI
9.85
Type
journal article
Language
en
Open access
closed
Licence
Funders
  • Deutsche Forschungsgemeinschaft (KFO 286, KFO 329, SFB 829, GRK 2407, SFB 670, SCHU 2494/3-1, SCHU 2494/15-1, SCHU 2494/10-1, SCHU 2494/11-1, SCHU 2494/7-1)
  • Horizon 2020
  • Stiftung Deutsche Krebshilfe (70112899)
  • John Templeton Foundation (61734)

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Vaddavalli, P. L., & Schumacher, B. (2022). The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends in Genetics. https://doi.org/10.1016/j.tig.2022.02.010

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