Cited by 93Fungal Infections and StudiesFungal and yeast genetics researchAntifungal resistance and susceptibility

The capsular dynamics of Cryptococcus neoformans

McFadden, Diane, Zaragoza, Oscar, Casadevall, Arturo·2006·Trends in Microbiology

Abstract

Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.

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Crossref · 10.1016/j.tim.2006.09.003

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86 of 86 references verified0 citation errors · 0 not checkable

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Authors
McFadden, D., Zaragoza, O., & Casadevall, A.
Affiliations
Albert Einstein College of Medicine (US)
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2006-11
Volume
14
Issue
11
Pages
497-505
ISSN
0966-842X (ISSN-L)
OpenAlex
W1986415424
Cited by
93
References
85
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl059842-23)
  • National Heart, Lung, and Blood Institute (HL 59842)
  • National Institute of Allergy and Infectious Diseases (AI 33142, AI33774, R01AI033774)
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
Cryptococcus neoformans, fungal capsule, capsule synthesis, capsule structure, budding, fungal virulence, immune evasion
MeSH terms
Cell Wall, Cryptococcus neoformans, Models, Biological, Polysaccharides

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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