The capsular dynamics of Cryptococcus neoformans
Abstract
Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.
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The Cryptococcus polysaccharide capsule modulates immune responses, enhances pathogenicity and confers protection against oxidative stress.
“The Cryptococcus polysaccharide capsule modulates immune responses, enhances pathogenicity and confers protection against oxidative stress55,56.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [56]
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Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo
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Self-citationRole for Chitin and Chitooligomers in the Capsular Architecture of Cryptococcus neoformans
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Self-citationRadial Mass Density, Charge, and Epitope Distribution in theCryptococcus neoformansCapsule
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Regulation of Cryptococcus neoformans Capsule Size Is Mediated at the Polymer Level
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The Elastic Properties of the Cryptococcus neoformans Capsule
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Capsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activity
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How Cryptococcus Interacts with the Blood–Brain Barrier
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Ultrastructural Study of Cryptococcus neoformans Surface During Budding Events
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The still obscure attributes of cryptococcal glucuronoxylomannan
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Self-citationDevelopmental Cell Fate and Virulence Are Linked to Trehalose Homeostasis in Cryptococcus neoformans
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Semisynthetic Glycoconjugate Vaccine Candidates against Cryptococcus neoformans
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Self-citationHIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC
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Antigen Titers in Cryptococcal Meningitis: What Determines How Fast They Fall?
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Self-citation
- Authors
- McFadden, D., Zaragoza, O., & Casadevall, A.
- Affiliations
- Albert Einstein College of Medicine (US)
- ORCID
- Casadevall, Arturo
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 14
- Issue
- 11
- Pages
- 497-505
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W1986415424
- Cited by
- 93
- References
- 85
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl059842-23)
- National Heart, Lung, and Blood Institute (HL 59842)
- National Institute of Allergy and Infectious Diseases (AI 33142, AI33774, R01AI033774)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Cryptococcus neoformans, fungal capsule, capsule synthesis, capsule structure, budding, fungal virulence, immune evasion
- MeSH terms
- Cell Wall, Cryptococcus neoformans, Models, Biological, Polysaccharides
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