Cited by 1,544Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsMemory Processes and Influences

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Pattern separation in the hippocampus

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Yassa, Michael A., Stark, Craig E.L.·2011·Trends in Neurosciences

DOI 10.1016/j.tins.2011.06.006PMC PMC3183227

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Abstract

The ability to discriminate among similar experiences is a crucial feature of episodic memory. This ability has long been hypothesized to require the hippocampus, and computational models suggest that it is dependent on pattern separation. However, empirical data for the role of the hippocampus in pattern separation have not been available until recently. This review summarizes data from electrophysiological recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, as well as human functional neuroimaging, that provide convergent evidence for the involvement of particular hippocampal subfields in this key process. We discuss the impact of aging and adult neurogenesis on pattern separation, and also highlight several challenges to linking across species and approaches, and suggest future directions for investigation.

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Authors: Yassa, M. A., & Stark, C. E. L.
Affiliations: Johns Hopkins University (US)
University of California, Irvine (US)
Corresponding author: Yassa, Michael A.
Stark, Craig E.L.
ORCID: Yassa, Michael A.
Stark, Craig E.L.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2011-10
Volume: 34
Issue: 10
Pages: 515-525
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2011.06.006
PMC: PMC3183227
OpenAlex: W2105089471
Cited by: 1,544
References: 113
Citations by year: 2026: 137 · 2025: 133 · 2024: 140 · 2023: 126 · 2022: 138 · 2021: 134 · 2020: 114 · 2019: 90 · 2018: 108 · 2017: 101 · 2016: 77 · 2015: 83 · 2014: 74 · 2013: 50 · 2012: 33
FWCI: 4.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG034613)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: pattern separation, hippocampus, episodic memory, hippocampal subfields, aging, adult neurogenesis, lesion studies, electrophysiology, immediate early genes, transgenic mouse model, functional neuroimaging
MeSH terms: Animals, Electrophysiology, Hippocampus, Humans, Memory, Models, Neurological, Nerve Net, Genes, Immediate-Early, Functional Neuroimaging

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