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Blood Cell MicroRNAs: What Are They and What Future Do They Hold?

Ryan, Patricia, Atreya, Chintamani·2011·Transfusion Medicine Reviews

Abstract

The advent of blood component storage revolutionized health care by allowing for a managed supply of transfusion quality blood products. During storage, blood components undergo a series of physiological changes that affect the product quality, which ultimately can interfere with the safety and efficacy of such products after transfusion. Despite continuous improvements in blood component quality and safety, it is still desirable to have in vitro standard markers of measurable characteristics that predict blood component safety and efficacy in vivo following their transfusion. Over the last decade, research on the feasibility of using microRNAs as biomarkers for various clinical manifestations and cellular pathologies has exploded. Here, we review the literature on blood cell microRNAs and discuss the potential of these molecules to act as measurable characteristics (product biomarkers) for stored blood component quality and safety.

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Crossref · 10.1016/j.tmrv.2011.01.005

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Research works printed but not linked: 38

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Metadata

Authors
Ryan, P., & Atreya, C.
Venue
Transfusion Medicine Reviews
Publisher
Elsevier BV
Published
2011-07
Volume
25
Issue
3
Pages
247-251
ISSN
0887-7963
Cited by
21
References
1
Language
en

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