Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila
Open accessAbstract
Increased levels of dysfunctional mitochondria within skeletal muscle are correlated with numerous age-related physiopathological conditions. Improving our understanding of the links between mitochondrial function and muscle proteostasis, and the role played by individual genes and regulatory networks, is essential to develop treatments for these conditions. One potential player is the mitochondrial outer membrane protein Fis1, a crucial fission factor heavily involved in mitochondrial dynamics in yeast but with an unknown role in higher-order organisms. By using Drosophila melanogaster as a model, we explored the effect of Fis1 mutations generated by transposon Minos-mediated integration. Mutants exhibited a higher ratio of damaged mitochondria with age as well as elevated reactive oxygen species levels compared with controls. This caused an increase in oxidative stress, resulting in large accumulations of ubiquitinated proteins, accelerated muscle function decline, and mitochondrial myopathies in young mutant flies. Ectopic expression of Fis1 isoforms was sufficient to suppress this phenotype. Loss of Fis1 led to unbalanced mitochondrial proteostasis within fly muscle, decreasing both flight capabilities and lifespan. Fis1 thus clearly plays a role in fly mitochondrial dynamics. Further investigations into the detailed function of Fis1 are necessary for exploring how mitochondrial function correlates with muscle health during aging.
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Loss of FIS1 results in impaired mitochondrial function and proteostasis in muscle, decreasing both flight capabilities and lifespan in FIS1 mutant flies.
“Another recent study revealed that loss of FIS1 results in impaired mitochondrial function and proteostasis in muscle, decreasing both flight capabilities and lifespan in FIS1 mutant flies (89).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [89]
Mitochondrial fission is essential for skeletal muscle health.
“Taken altogether, the findings discussed above clearly indicate that mitochondrial fission is essential for skeletal muscle health.”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [45]
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- Authors
- Lee, T., Chen, P., Su, M. P., Li, J., Chang, Y., Liu, R., Juan, H., Yang, J., Chan, S., Tsai, Y., von Stockum, S., Ziviani, E., Kamikouchi, A., Wang, H., & Chen, C.
- Affiliations
- National Health Research Institutes (TW)
- Nagoya University (JP)
- National Taiwan University (TW)
- National Yang Ming Chiao Tung University (TW)
- Tunghai University (TW)
- Department of Biology University of Padova Padova Italy
- University of Padua (IT)
- National Tsing Hua University (TW)
- Corresponding author
- Chen, Chun‐Hong
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2021-06
- Volume
- 20
- Issue
- 6
- Pages
- e13379-e13379
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC8208795
- OpenAlex
- W3165819898
- Cited by
- 27
- References
- 70
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- Academia Sinica
- National Health Research Institutes (08A1-MRGP12-035, NHRI-08A1-MRGP12-035)
- Japan Society for the Promotion of Science (20F20386, 20H03355)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- Fis1, mitochondrial fission, mitochondrial dynamics, skeletal muscle aging, proteostasis, mitochondrial dysfunction, oxidative stress, reactive oxygen species, ubiquitinated proteins, mitochondrial myopathy, flight performance, lifespan, Drosophila melanogaster
- MeSH terms
- Proteostasis, Aging, Animals, Drosophila melanogaster, Membrane Proteins, Muscle, Skeletal, Mitochondrial Proteins
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