The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease
Open accessAbstract
Introduction: We assessed the feasibility and cognitive effects of a ketogenic diet (KD) in participants with Alzheimer's disease. Methods: The Ketogenic Diet Retention and Feasibility Trial featured a 3‐month, medium‐chain triglyceride–supplemented KD followed by a 1‐month washout in clinical dementia rating (CDR) 0.5, 1, and 2 participants. We obtained urine acetoacetate, serum β‐hydroxybutyrate, food record, and safety data. We administered the Alzheimer's Disease Assessment Scale‐cognitive subscale and Mini–Mental State Examination before the KD, and following the intervention and washout. Results: We enrolled seven CDR 0.5, four CDR 1, and four CDR 2 participants. One CDR 0.5 and all CDR 2 participants withdrew citing caregiver burden. The 10 completers achieved ketosis. Most adverse events were medium‐chain triglyceride–related. Among the completers, the mean of the Alzheimer's Disease Assessment Scale‐cognitive subscale score improved by 4.1 points during the diet ( P = .02) and reverted to baseline after the washout. Discussion: This pilot trial justifies KD studies in mild Alzheimer's disease.
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A new predictive equation for resting energy expenditure in healthy individuals
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Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
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Protein acetylation in metabolism – metabolites and cofactors
Menzies, K. J., Zhang, H., Katsyuba, E., & Auwerx, J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.181 · Cited by 331
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0072-x · Cited by 1,003
Self-citationLipids and Alzheimer’s Disease
Kao, Y.-C., Ho, P.-C., Tu, Y.-K., Jou, I.-M., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041505 · Cited by 485
Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441
Perez Ortiz, J. M., & Swerdlow, R. H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14585 · Cited by 426
Self-citationKetogenic Diet in Alzheimer’s Disease
Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163892 · Cited by 319
Metadata
- Authors
- Taylor, M. K., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H.
- Venue
- Alzheimer's & Dementia: Translational Research & Clinical Interventions
- Publisher
- Wiley
- Published
- 2017-12-04
- Volume
- 4
- Issue
- 1
- Pages
- 28-36
- ISSN
- 2352-8737 (ISSN-L)
- OpenAlex
- W2772361019
- Cited by
- 272
- References
- 6
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- gold
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