Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects
Abstract
While many neuropsychological studies have demonstrated age-related performance alterations in tests thought to reflect frontal and temporal lobe function, there is little direct observation and comparison of these hypothesized brain changes in vivo. The cerebral glucose metabolism of frontal, temporal, and cerebellar regions was examined in 40 young (mean = 27.5 +/- 4.9) and 31 elderly (mean = 67.6 +/- 8.8) normal males using PET-FDG. Univariate analysis showed age-related metabolic reductions in all frontal and temporal lobe regions. The reductions ranged from 13%-24% with the greatest changes in the frontal lobes. Multiple regression analyses showed a stronger age relationship with frontal lobe than with temporal lobe metabolism. The dorsal lateral frontal lobe was the region that appears to change most within the frontal lobes. Examination of the temporal lobe showed that age contributed equally to the metabolic variance of both the lateral temporal lobe and hippocampus. These results suggest that age-related metabolic changes exist in both frontal and temporal lobes and that the frontal lobe change is greater.
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Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD.
“Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD [185-193].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [185]
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Ketotherapeutics to Rescue Brain Energy Deficits
Myette‐Côté, É., Castellano, C., Fortier, M., St‐Pierre, V., & Cunnane, S. C. (2022) · doi:10.1093/med/9780197501207.003.0017
Lu, J., Ma, J., Xiang, Y., Wu, J., Zheng, M., Li, L., Hua, X., & Xu, J. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150441
- Authors
- De Santi, S., de Leon, M. J., Convit, A., Tarshish, C., Rusinek, H., Tsui, W. H., Sinaiko, E., Wang, G.-J., Bartlet, E., & Volkow, N.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- NYU Langone Health (US)
- Brookhaven National Laboratory (US)
- Venue
- Psychiatric Quarterly
- Published
- 1995-12
- Volume
- 66
- Issue
- 4
- Pages
- 357-370
- ISSN
- 0033-2720 (ISSN-L)
- 1573-6709
- OpenAlex
- W2086051267
- Cited by
- 74
- References
- 24
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 5
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychiatric Quarterly (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh043965-07)
- National Institute on Aging (P30 AG 08051, AG 12101, P30AG008051)
- National Institute of Mental Health (MH43965)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- brain aging, brain glucose metabolism, frontal lobe, temporal lobe, hippocampus, cerebellum, FDG-PET, age-related metabolic decline, dorsolateral prefrontal cortex
- MeSH terms
- Adult, Aged, Aging, Blood Glucose, Cerebellum, Deoxyglucose, Energy Metabolism, Female, Frontal Lobe, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Reference Values, Temporal Lobe, Tomography, Emission-Computed, Fluorodeoxyglucose F18
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