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Cited by 272

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease

Open access
Taylor, Matthew K., Sullivan, Debra K., Mahnken, Jonathan D., Burns, Jeffrey M., Swerdlow, Russell H.·2018·Alzheimer's & Dementia: Translational Research & Clinical Interventions
DOI 10.1016/j.trci.2017.11.002
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Abstract

Introduction: We assessed the feasibility and cognitive effects of a ketogenic diet (KD) in participants with Alzheimer's disease. Methods: The Ketogenic Diet Retention and Feasibility Trial featured a 3‐month, medium‐chain triglyceride–supplemented KD followed by a 1‐month washout in clinical dementia rating (CDR) 0.5, 1, and 2 participants. We obtained urine acetoacetate, serum β‐hydroxybutyrate, food record, and safety data. We administered the Alzheimer's Disease Assessment Scale‐cognitive subscale and Mini–Mental State Examination before the KD, and following the intervention and washout. Results: We enrolled seven CDR 0.5, four CDR 1, and four CDR 2 participants. One CDR 0.5 and all CDR 2 participants withdrew citing caregiver burden. The 10 completers achieved ketosis. Most adverse events were medium‐chain triglyceride–related. Among the completers, the mean of the Alzheimer's Disease Assessment Scale‐cognitive subscale score improved by 4.1 points during the diet ( P = .02) and reverted to baseline after the washout. Discussion: This pilot trial justifies KD studies in mild Alzheimer's disease.

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Metadata

Authors
Taylor, M. K., Sullivan, D. K., Mahnken, J. D., Burns, J. M., & Swerdlow, R. H.
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2017-12-04
Volume
4
Issue
1
Pages
28-36
ISSN
2352-8737 (ISSN-L)
DOI
10.1016/j.trci.2017.11.002
OpenAlex
W2772361019
Cited by
272
References
6
FWCI
13.91
Type
journal article
Language
en
Open access
gold

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