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Cited by 80Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Amyloid‐associated increases in longitudinal report of subjective cognitive complaints

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Amariglio, Rebecca E., Buckley, Rachel F., Mormino, Elizabeth C., Marshall, Gad A., Johnson, Keith A., Rentz, Dorene M., Sperling, Reisa A.·2018·Alzheimer's & Dementia: Translational Research & Clinical Interventions
DOI 10.1016/j.trci.2018.08.005PMC PMC6153378
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Abstract

Introduction: To investigate whether baseline subjective cognitive complaints (SCCs) predict longitudinal decline on neuropsychological testing and whether SCC increases longitudinally, in the setting of high levels of amyloid burden. Methods: Two hundred seventy‐nine clinically normal older participants (mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of community‐dwelling individuals, were followed longitudinally (4.27 ± 1.35 years) with annual subjective memory questionnaires and neuropsychological assessment. 11 C Pittsburgh compound‐B positron emission tomography was used to measure cortical amyloid and to classify status (Aβ+/Aβ−) at baseline. Results: Higher baseline SCC predicted more rapid cognitive decline on neuropsychological measures among those with elevated amyloid (t = −2.18, P < .0001). In addition, longitudinal report of SCC significantly increased over time, with SCC progression most pronounced among Aβ+ individuals (t = 2.24, P = .0005). Discussion: SCC may inform risk for future cognitive decline and track progression of self‐perceived decline, particularly in those along the AD trajectory, providing potentially important indicators of clinical meaningfulness in AD prevention trials.

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  • Higher amyloid aggregation at baseline indicated a faster rate of decline in various cognition domains and a more rapid increase in SCD severity over time in individuals with SCD.

    “Recently, several studies have consistently suggested that higher amyloid aggregation at baseline indicated a faster rate of decline in various cognition domains [37, 38] and a more rapid increase in SCD severity over time [39] in individuals with SCD.”

    From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [39]

    The Results and Discussion report that subjective cognitive complaints increased most rapidly among participants with elevated baseline amyloid. However, the Discussion states that participants were not required to have baseline complaints, so the finding is not specifically established for individuals with SCD. Citation [39] is attached to the increase in SCD severity, not the separate claim about decline across cognitive domains. (LLM, conf=0.88)

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Research works printed but not linked: 32

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Authors
Amariglio, R. E., Buckley, R. F., Mormino, E. C., Marshall, G. A., Johnson, K. A., Rentz, D. M., & Sperling, R. A.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Amariglio, Rebecca E.
ORCID
Venue
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publisher
Wiley
Published
2018-01
Volume
4
Issue
1
Pages
444-449
ISSN
2352-8737 (ISSN-L)
DOI
10.1016/j.trci.2018.08.005
PMC
PMC6153378
OpenAlex
W2889724547
Cited by
80
References
4
Citations by year
2026: 2 · 2025: 9 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 17 · 2020: 19 · 2019: 12 · 2018: 1
FWCI
9.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institutes of Health (K23AG044431, AG027435, R01EB014894, P01 AG036694)
  • National Health and Medical Research Council (APP1105576)
  • National Institute on Aging (K01‐AG051718)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
subjective cognitive complaints, amyloid burden, cognitive decline, Alzheimer's disease, Pittsburgh compound B PET, older adults, subjective memory complaints, long-term tracking

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