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Cited by 109Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAging and Gerontology Research

The DOI matches its Crossref record; 26 of the 29 references it cites were found in a registry or an index.

Memory complaints and risk of cognitive impairment after nearly 2 decades among older women

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Kaup, Allison R., Nettiksimmons, Jasmine, LeBlanc, Erin S., Yaffe, Kristine·2015·Neurology
DOI 10.1212/wnl.0000000000002153PMC PMC4662698
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Abstract

OBJECTIVES: To investigate the association between subjective memory complaints (SMCs) and long-term risk of cognitive impairment in aging because most previous studies have followed individuals for only a few years. METHODS: Participants were 1,107 cognitively normal, community-dwelling older women (aged 65 years and older at baseline) in a prospective study of aging. SMCs were assessed shortly after baseline and repeatedly over time with the yes/no question, "Do you feel you have more problems with memory than most?" Cognitive status 18 years later (normal or impaired with mild cognitive impairment or dementia) was determined by an expert panel. Using logistic regression, we investigated the association between SMCs over time and risk of cognitive impairment, adjusting for demographics, baseline cognition, and characteristics that differed between those with and without SMCs. RESULTS: At baseline, 8.0% of participants (n = 89) endorsed SMCs. Baseline SMCs were associated with increased risk of cognitive impairment 18 years later (adjusted odds ratio [OR] = 1.7, 95% confidence interval 1.1-2.8). Results were unchanged after excluding participants with depression. The association between SMCs and cognitive impairment was greatest at the last SMC assessment time point (18 years before diagnosis: adjusted OR = 1.7 [1.1-2.9]; 14 years before diagnosis: adjusted OR = 1.6 [0.9-2.7]; 10 years before diagnosis: adjusted OR = 1.9 [1.1-3.1]; 4 years before diagnosis: adjusted OR = 3.0 [1.8-5.0]). CONCLUSIONS: SMCs are associated with cognitive impairment nearly 2 decades later among older women. SMCs may be a very early symptom of an insidious neurodegenerative disease process, such as Alzheimer disease.

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Metadata

Authors
Kaup, A. R., Nettiksimmons, J., LeBlanc, E. S., & Yaffe, K.
Affiliations
San Francisco VA Medical Center (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-11-24
Volume
85
Issue
21
Pages
1852-1858
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000002153
PMC
PMC4662698
OpenAlex
W2193383487
Cited by
109
References
29
Citations by year
2026: 5 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 16 · 2020: 16 · 2019: 20 · 2018: 10 · 2017: 11 · 2016: 4
FWCI
6.76
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Neurology (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • U.S. Department of Veterans Affairs (IK2 RX001629)
  • Kaiser Permanente
  • University of Minnesota
  • University of Pittsburgh
  • National Institute on Aging (R01AG005394, R01AG005407, R01AG027576, K24AG031155, R01AG026720, R01AG027574)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR35582, R01AR035584, R01AR35583, R01AR035582, R01AR035583, R01‐AR‐35584)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords
subjective memory complaints, cognitive impairment, older women, long-term risk, mild cognitive impairment, dementia, Alzheimer's disease, aging, early detection of neurodegeneration
MeSH terms
Aged, Aging, Female, Humans, Memory Disorders, Prospective Studies, Risk Factors, Time Factors, Cohort Studies, Cognitive Dysfunction

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