Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project
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We examined the relationships between amyloid-β PET and concurrent and longitudinal cognitive performance in 107 cognitively normal individuals with subjective cognitive decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 ± 1). All underwent 90-minute dynamic [ 18 F]florbetapir PET scanning and longitudinal neuropsychological tests with a mean follow-up of 3.4 ± 3.0 years. Receptor parametric mapping was used to calculate [ 18 F]florbetapir binding potential (BP ND ), and we performed linear mixed models to assess the relationships between global [ 18 F]florbetapir BP ND and neuropsychological performance. Higher [ 18 F]florbetapir BP ND was related to lower concurrent Mini-Mental State Examination (β ± SE: −1.69 ± 0.63 p < 0.01) and to steeper rate of decline on tasks capturing memory (Rey Auditory Verbal Learning Task immediate [β ± SE −1.81 ± 0.81, p < 0.05] and delayed recall [β ± SE −1.19 ± 0.34, p < 0.01]), attention/executive functions (Stroop II [color] [β ± SE −0.02 ± 0.01, p < 0.05], Stroop III [word-color] [β ± SE −0.03 ± 0.02, p < 0.05]), and language (category fluency [β ± SE −0.04 ± 0.01, p < 0.01]). These findings suggest that higher amyloid-β load in cognitively normal individuals with subjective cognitive decline from a memory clinic is associated with lower concurrent global cognition and with faster rate of decline in a variety of cognitive domains.
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Higher amyloid aggregation at baseline indicated a faster rate of decline in various cognition domains and a more rapid increase in SCD severity over time in individuals with SCD.
“Recently, several studies have consistently suggested that higher amyloid aggregation at baseline indicated a faster rate of decline in various cognition domains [37, 38] and a more rapid increase in SCD severity over time [39] in individuals with SCD.”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [38]
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Additional file 1 of Cognitive trajectories of patients with focal ß-amyloid deposition
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Additional file 1 of Alzheimer’s disease-related transcriptional sex differences in myeloid cells
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Brain [18F]FDG-PET in Subjective Cognitive Complaints
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- Authors
- Timmers, T., Ossenkoppele, R., Verfaillie, S. C. J., van der Weijden, C. W. J., Slot, R. E. R., Wesselman, L. M. P., Windhorst, A. D., Wolters, E. E., Yaqub, M., Prins, N. D., Lammertsma, A. A., Scheltens, P., van der Flier, W. M., & van Berckel, B. N. M.
- Affiliations
- Amsterdam University Medical Centers (NL)
- Lund University (SE)
- Corresponding author
- Timmers, Tessa
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 79
- Pages
- 50-58
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2920874722
- Cited by
- 63
- References
- 61
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 8 · 2019: 3
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Funders
- Alzheimer Nederland
- Amsterdam Neuroscience
- GIESKES-STRIJBIS FONDS
- Avid Radiopharmaceuticals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- amyloid PET, 18F-florbetapir, binding potential, subjective cognitive decline, cognitively normal individuals, cognitive decline, memory decline, executive function, attention, language, Mini-Mental State Examination
- MeSH terms
- Aged, Cognition, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Amyloid beta-Peptides, Positron-Emission Tomography, Cognitive Dysfunction
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