The polymorphic prelude to Bateson–Dobzhansky–Muller incompatibilities
Abstract
Speciation research has largely assumed that the genetic causes of reproductive isolation are the work of fixed, divergent alleles that interact to cause genetic problems in hybrids: Bateson-Dobzhansky-Muller incompatibilities. However, many recent studies demonstrate substantial heritable polymorphism within species for hybrid incompatibility, herein called variable reproductive isolation (VRI). In this review, I outline the causes and importance of this general phenomenon. I also identify the new challenges of quantifying the relative contributions to reproductive isolation of fixed alleles versus polymorphisms, and the change in these contributions over the course of speciation. Explicit integration of VRI into speciation theory will help to quantify the relative roles of genetic drift and selection in speciation, but this synthesis requires substantial new contributions from both theory and empirical studies.
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Incompatibilities are often polymorphic in nature.
“incompatibilities are often polymorphic in nature (Cutter 2012).”
From Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations (2021) · cites this paper as Cutter 2012
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Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations
Blanckaert, A., & Payseur, B. A. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab168 · Cited by 7 · see citing works
“Although our simulations as-490 sumed that incompatibility alleles were fixed in source populations, incompatibilities are often polymorphic in nature (Cutter, 2012).”
Background
- Authors
- Cutter, A. D.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Cutter, Asher D.
- ORCID
- Cutter, Asher D.
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 27
- Issue
- 4
- Pages
- 209-218
- ISSN
- 0169-5347 (ISSN-L)
- OpenAlex
- W1974240519
- Cited by
- 220
- References
- 107
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 18 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 16 · 2018: 7 · 2017: 37 · 2016: 18 · 2015: 13 · 2014: 18 · 2013: 11 · 2012: 4
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Ecology & Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- hybrid incompatibility, speciation, reproductive isolation, genetic drift, natural selection, speciation theory
- MeSH terms
- Alleles, Animals, Models, Theoretical, Plants, Polymorphism, Genetic
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