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Cited by 165Microbial infections and disease researchAnimal health and immunologyAnimal Virus Infections Studies

Etiology of respiratory disease in non-vaccinated, non-medicated calves in rearing herds.

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Autio, T., Pohjanvirta, T., Holopainen, R., Rikula, U., Pentikäinen, J., Huovilainen, A., Rusanen, H., Soveri, T. +2 more·2007·Veterinary Microbiology
DOI 10.1016/j.vetmic.2006.10.001PMC PMC7130506
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Abstract

The aim of this study was to examine the occurrence of bacterial, mycoplasmal and viral pathogens in the lower respiratory tract of calves in all-in all-out calf-rearing units. According to clinical status, non-medicated calves with and without respiratory disease signs were selected of the 40 herds investigated to analyse the micro-organisms present in healthy and diseased calves. Tracheobronchial lavage (TBL) and paired serum samples were analysed for bacteria, mycoplasmas, respiratory syncytial virus (RSV), parainfluenza virus 3 (PIV3), bovine corona virus (BCV) and bovine adenovirus (BAV). Pasteurella multocida was the most common bacterial pathogen. It was isolated from 34% of the TBL samples in 28 herds and was associated with clinical respiratory disease (p < 0.05) when other pathogenic bacteria or mycoplasma were present in the sample. Mannheimia spp. and Histophilus somni were rarely found. Mycoplasma bovis was not detected at all. Ureaplasma diversum was associated with clinical respiratory disease (p < 0.05). TBL samples from healthy or suspect calves were more often negative in bacterial culture than samples from diseased calves (p < 0.05). No viral infections were detected in six herds, while 16-21 herds had RSV, BCV, BAV or PIV3. In the herds that had calves seroconverted to BCV, respiratory shedding of BCV was more frequently observed than faecal shedding. This study showed that the microbial combinations behind BRD were diverse between herds. M. bovis, an emerging pathogen in many countries, was not detected.

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  • At the collection center, during transport, calves from different farms are mixed together and exposed to new environmental conditions, including new microorganisms, against which they may not have obtained colostral antibodies.

    “At the CC, during transport, calves from different farms are mixed together and exposed to new environmental conditions, including new microorganisms, against which they may not have obtained colostral antibodies (Autio et al., 2007”

    From Effects of pretransport diet, transport duration, and type of vehicle on physiological status of young veal calves. (2020) · cites this paper as Autio et al., 2007

    The Introduction says calves from several dairy farms are transported to a rearing unit and that mixing calves from different farms exposes them to a heavy infection load, including microbes against which their dams lack colostral antibodies. It does not say that the mixing occurs at a collection center or during transport, or specifically describe exposure to new environmental conditions there. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. Johansson K.E. Berg L.O. Bölske G. Deniz S. Matsson J. Persson M. Pettersson K. Specific PCR systems based on the 16S rRNA genes of Mycoplasma agalactiae and Mycoplasma bovis Mycoplasmas of Ruminants: Pathogenicity, Diagnostics, Epidemiology and Molecular Genetics 1996 European Commission Brussels pp. 88–90
  2. Maheswaran, S.K., Thumbikat, P., Dileepan, T., 2002. Current knowledge on pathogenesis of lung injury caused by Mannheimia haemolytica and Pasteurella multocida in the bovine. In: Kaske, M., Scholz, H., Holtershinken, M. (Eds.), XXII World Buiatrics Congress. Recent developments and perspectives in bovine medicine. Hannover, Germany, Klinik für Rinderkrankheiten, Tierarztliche Hochschule Hannover, 2002, pp. 160–167.

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Authors
Autio, T., Pohjanvirta, T., Holopainen, R., Rikula, U., Pentikäinen, J., Huovilainen, A., Rusanen, H., Soveri, T., Sihvonen, L., & Pelkonen, S.
Affiliations
University of Helsinki (FI)
Corresponding author
Autio, T.
ORCID
Venue
Veterinary Microbiology
Publisher
Elsevier BV
Published
2007-01
Volume
119
Issue
2-4
Pages
256-265
ISSN
0378-1135 (ISSN-L)
DOI
10.1016/j.vetmic.2006.10.001
PMC
PMC7130506
OpenAlex
W2064553450
Cited by
165
References
36
Citations by year
2026: 8 · 2025: 6 · 2024: 12 · 2023: 11 · 2022: 7 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 9
FWCI
3.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Veterinary Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Veterinary › Small Animals › Animal health and immunology
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
bovine respiratory disease, calves, Pasteurella multocida, Ureaplasma diversum, Mannheimia, Histophilus somni, Mycoplasma bovis, respiratory syncytial virus, parainfluenza virus type 3, bovine coronavirus, bovine adenovirus, seroconversion
MeSH terms
Animals, Bronchoalveolar Lavage Fluid, Cattle, Cattle Diseases, Finland, Lung, Mycoplasma, Pasteurella Infections, Pneumonia, Mycoplasma, Respiratory Tract Infections, Species Specificity, Ureaplasma, Ureaplasma Infections, Mannheimia haemolytica, Pasteurella multocida, Bronchoalveolar Lavage

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