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HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition
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“HPV oncoproteins E6 and E7 have been shown to activate EMT-inducing transcriptional factors—Slug, Twizt, ZEB1 and ZEB2—resulting in an increase in mesenchymal markers such as N-cadherin, fibronectin and vimentin and a decrease in epithelial cell markers like E-cadherin [257,258]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [258]
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The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017 · cited 1×
“High-risk HPV E7 proteins bind and induce the degradation of the hypophosphorylated, growth suppressive form of the retinoblastoma tumor suppressor protein (pRB) (Boyer et al., 1996; Dyson et al., 1992, 1989; Jones and Munger, 1997) causing persistent activation of E2F transcription factors.”
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Cited by
Tan, T. Z., Miow, Q. H., Miki, Y., Noda, T., Mori, S., Huang, R. Y., & Thiery, J. P. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404208 · Cited by 792
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Yamben, I. F., Rachel, R. A., Shatadal, S., Copeland, N. G., Jenkins, N. A., Warming, S., & Griep, A. E. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.09.027 · Cited by 50
Metadata
- Authors
- Hellner, K., Mar, J., Fang, F., Quackenbush, J., & Münger, K.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 391
- Issue
- 1
- Pages
- 57-63
- ISSN
- 0042-6822
- PMC
- PMC2728214
- Cited by
- 94
- References
- 2
- Language
- en
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