Cited by 203Cytomegalovirus and herpesvirus researchTelomeres, Telomerase, and SenescenceImmune responses and vaccinations

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Role of CMV in immune senescence.

Pawelec, Graham, Derhovanessian, Evelyna·2011·Virus Research

DOI 10.1016/j.virusres.2010.09.010

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Abstract

"Immune senescence" is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so far. While all components of innate and adaptive immunity are changed with age, the clinical impact of these changes is not clear, and mechanisms of and markers for immunosenescence are controversial. In humans, several cross-sectional studies have demonstrated that the major accepted age-associated changes to parameters used to assess adaptive immune status are markedly influenced by infection with cytomegalovirus (CMV). In the very limited longitudinal studies thus far carried out, a cluster of immune parameters associating with 2-, 4- and 6-year survival of the very elderly has been identified and termed the "immune risk profile" (IRP). This cluster includes seropositivity for CMV and is characterised by accumulations of clonal expansions of late-differentiated CD8+ T cells, many of which are specific for CMV antigens. Here we review the impact of CMV on "immune senescence" in humans.

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Authors: Pawelec, G., & Derhovanessian, E.
Affiliations: University of Tübingen (DE)
Corresponding author: Pawelec, Graham
ORCID: Pawelec, Graham
Venue: Virus Research
Publisher: Elsevier BV
Published: 2011-05
Volume: 157
Issue: 2
Pages: 175-179
ISSN: 0168-1702 (ISSN-L)
DOI: 10.1016/j.virusres.2010.09.010
OpenAlex: W1983064582
Cited by: 201
References: 60
Citations by year: 2026: 9 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 20 · 2016: 17 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 20
FWCI: 11.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Virus Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: cytomegalovirus, immunosenescence, CD8+ T cells, clonal expansion, CMV seropositivity, aging
MeSH terms: Aging, Cytomegalovirus Infections, Cytomegalovirus, Humans, Immunity, Risk Factors, CD8-Positive T-Lymphocytes

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