Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study
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Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection are underway, but concerns have been raised regarding the potential harm of strong innate immune responses. To investigate the safety of BCG vaccination, we retrospectively assessed coronavirus disease 2019 (COVID-19) and related symptoms in three cohorts of healthy volunteers who either received BCG in the last 5 years or did not. BCG vaccination is not associated with increased incidence of symptoms during the COVID-19 outbreak in the Netherlands. Our data suggest that BCG vaccination might be associated with a decrease in the incidence of sickness during the COVID-19 pandemic (adjusted odds ratio [AOR] 0.58, p < 0.05), and lower incidence of extreme fatigue. In conclusion, recent BCG vaccination is safe, and large randomized trials are needed to reveal if BCG reduces the incidence and/or severity of SARS-CoV-2 infection.
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Trained immunity is a specialized form of innate immune memory, best characterized for BCG vaccination and β-glucan stimulation.
“A specialized form of innate immune adaptation is the induction of immune memory (also termed trained immunity)”
From COVID-19 and the human innate immune system (2021) · cites this paper as Moorlag et al., 2020
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016 · see citing works
Pathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545 · see citing works
Trained immunity: A program of innate immune memory in health and– disease
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768 · see citing works
Self-citationThe pathogenesis and treatment of the `Cytokine Storm' in COVID-19
Ye, Q., Wang, B., & Mao, J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.03.037 · Cited by 2,761 · see citing works
Defining trained immunity and its role in health and disease
Netea, M. G., Domínguez-Andrés, J., Barreiro, L. B., Chavakis, T., Divangahi, M., Fuchs, E., Joosten, L. A. B., van der Meer, J. W. M., Mhlanga, M. M., Mulder, W. J. M., et al. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0285-6 · Cited by 2,690 · see citing works
Self-citationEffective treatment of severe COVID-19 patients with tocilizumab
Xu, X., Han, M., Li, T., Sun, W., Wang, D., Fu, B., Zhou, Y., Zheng, X., Yang, Y., Li, X., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005615117 · Cited by 2,636 · see citing works
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
Giamarellos-Bourboulis, E. J., Netea, M. G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., Katsaounou, P., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.009 · Cited by 2,045 · see citing works
Self-citationAssarsson, E., Lundberg, M., Holmquist, G., Björkesten, J., Bucht Thorsen, S., Ekman, D., Eriksson, A., Rennel Dickens, E., Ohlsson, S., Edfeldt, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095192 · Cited by 1,874 · see citing works
Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728 · see citing works
Self-citationArts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S.-Y., Oosting, M., Kumar, V., Xavier, R. J., Wijmenga, C., Joosten, L. A. B., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2017.12.010 · Cited by 1,190 · see citing works
Self-citationCavalli, G., Luca, G. D. D., Campochiaro, C., Della‐Torre, E., Ripa, M., Canetti, D., Oltolini, C., Castiglioni, B., Din, C. T., Boffini, N., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30127-2 · Cited by 971 · see citing works
Immunometabolic Pathways in BCG-Induced Trained Immunity
Arts, R. J. W., Carvalho, A., Rocca, C. L., Palma, C., Rodrigues, F. J. S., Silvestre, R., Kleinnijenhuis, J., Lachmandas, E., Gonçalves, L. G., Belinha, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.011 · Cited by 677 · see citing works
Self-citationProtecting health-care workers from subclinical coronavirus infection
Chang, D., Xu, H., Rebaza, A., Sharma, L., & Dela Cruz, C. S. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30066-7 · Cited by 664 · see citing works
Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers
Chou, R., Dana, T., Buckley, D., Selph, S., Fu, R., & Totten, A. M. (2020) · Annals of Internal Medicine · doi:10.7326/m20-1632 · Cited by 645 · see citing works
Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review
Higgins, J. P. T., Soares‐Weiser, K., López-López, J. A., Κακούρου, Α., Chaplin, K., Christensen, H., Martin, N. K., Sterne, J. A. C., & Reingold, A. L. (2016) · BMJ · doi:10.1136/bmj.i5170 · Cited by 629 · see citing works
Aaby, P., Roth, A., Ravn, H., Napirna, B. M., Rodrigues, A., Lisse, I. M., Stensballe, L. G., Diness, B. R., Lausch, K. R., Lund, N., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir240 · Cited by 581 · see citing works
Self-citationBCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
Cirovic, B., de Bree, L. C. J., Groh, L., Blok, B. A., Chan, J., van der Velden, W. J. F. M., Bremmers, M. E. J., van Crevel, R., Händler, K., Picelli, S., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.014 · Cited by 510 · see citing works
Self-citationCorrelation between universal BCG vaccination policy and reduced mortality for COVID-19Preprint
Miller, A., Reandelar, M. J., Fasciglione, K., Roumenova, V., Li, Y., & Otazu, G. H. (2020) · medRxiv · doi:10.1101/2020.03.24.20042937 · Cited by 507 · see citing works
BCG-induced trained immunity: can it offer protection against COVID-19?
O'Neill, L. A. J., & Netea, M. G. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0337-y · Cited by 501 · see citing works
Self-citationNon-specific effects of BCG vaccine on viral infections
Moorlag, S. J. C. F. M., Arts, R. J. W., van Crevel, R., & Netea, M. G. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.04.020 · Cited by 479 · see citing works
Self-citationTrained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection
Netea, M. G., Giamarellos‐Bourboulis, E. J., Domínguez‐Andrés, J., Curtis, N. C., van Crevel, R., van de Veerdonk, F. L., & Bonten, M. J. M. (2020) · Cell · doi:10.1016/j.cell.2020.04.042 · Cited by 462 · see citing works
Self-citationConsidering BCG vaccination to reduce the impact of COVID-19
Curtis, N. C., Sparrow, A., Ghebreyesus, T. A., & Netea, M. G. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31025-4 · Cited by 346 · see citing works
Self-citationA Functional Genomics Approach to Understand Variation in Cytokine Production in Humans
Li, Y., Oosting, M., Smeekens, S. P., Jaeger, M., Aguirre-Gamboa, R., Le, K. T. T., Deelen, P., Ricaño-Ponce, I., Schoffelen, T., Jansen, A. F. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.017 · Cited by 324 · see citing works
Self-citationSciascia, S., Aprà, F., Baffa, A., Baldovino, S., Boaro, D., Boero, R., Bonora, S., Calcagno, A., Cecchi, I., Cinnirella, G., et al. (2020) · PubMed · Cited by 303 · see citing works
Biering-Sørensen, S. R., Aaby, P., Lund, N., Monteiro, I., Jensen, K. J., Eriksen, H. B., Schaltz‐Buchholzer, F., Jørgensen, A. S. P., Rodrigues, A., Fisker, A. B., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix525 · Cited by 294 · see citing works
Self-citationStensballe, L. G., Nante, E., Jensen, I. P., Kofoed, P., Poulsen, A., Jensen, H., Newport, M. J., Marchant, A., & Aaby, P. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.09.006 · Cited by 247 · see citing works
Self-citationBuffen, K., Oosting, M., Quintin, J., Ng, A., Kleinnijenhuis, J., Kumar, V., van de Vosse, E., Wijmenga, C., van Crevel, R., Oosterwijk, E., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004485 · Cited by 231 · see citing works
Self-citationBiering-Sørensen, S. R., Aaby, P., Napirna, B. M., Roth, A., Ravn, H., Rodrigues, A., Whittle, H. C., & Benn, C. S. (2011) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182458289 · Cited by 226 · see citing works
Self-citationSARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults
Hamiel, U., Kozer, E., & Youngster, I. (2020) · JAMA · doi:10.1001/jama.2020.8189 · Cited by 211 · see citing works
Wardhana, Datau, E. A., Sultana, A., Mandang, V. V. V., & Jim, E. (2011) · PubMed · Cited by 199 · see citing works
Mycobacterial growth inhibition is associated with trained innate immunity
Joosten, S. A., van Meijgaarden, K. E., Arend, S. M., Prins, C., Oftung, F., Korsvold, G. E., Kik, S. V., Arts, R. J. W., van Crevel, R., Netea, M. G., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97508 · Cited by 180 · see citing works
Self-citationWikman, A., Marklund, S., & Alexanderson, K. A. E. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.025346 · Cited by 172 · see citing works
Spencer, J., Ganguly, R. G., & Waldman, R. H. (1977) · The Journal of Infectious Diseases · doi:10.1093/infdis/136.2.171 · Cited by 130 · see citing works
Differential COVID-19-attributable mortality and BCG vaccine use in countriesPreprint
Shet, A., Ray, D., Malavige, N., Santosham, M., & Bar‐Zeev, N. (2020) · medRxiv · doi:10.1101/2020.04.01.20049478 · Cited by 93 · see citing works
Effects of Immunostimulants on Resistance of Newborn Mice to Herpes Simplex Type 2 Infection
Starr, S. E., Visintine, A. M., Tomeh, M. O., & Nahmias, A. J. (1976) · Experimental Biology and Medicine · doi:10.3181/00379727-152-39327 · Cited by 93 · see citing works
Prevention of elderly pneumonia by pneumococcal, influenza and BCG vaccinations
Ohrui, T., Nakayama, K., Fukushima, T., Chiba, H., & Sasaki, H. (2005) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.42.34 · Cited by 76 · see citing works
Sala, G., Chakraborti, R., Ota, A., & Miyakawa, T. (2020) · medRxiv · doi:10.1101/2020.03.30.20048165 · Cited by 71 · see citing works
Green, C. M., Fanucchi, S., Domínguez‐Andrés, J., Fok, E. T., Moorlag, S. J. C. F. M., Negishi, Y., Joosten, L. A. B., Netea, M. G., & Mhlanga, M. M. (2020) · medRxiv · doi:10.1101/2020.04.10.20060905 · Cited by 20 · see citing works
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Flagged first, then by citations
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Cited by
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COVID-19 and the human innate immune system
Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714 · see citing works
Trained immunity: adaptation within innate immune mechanisms
Domínguez‐Andrés, J., dos Santos, J. C., Bekkering, S., Mulder, W. J. M., van der Meer, J. W. M., Riksen, N. P., Joosten, L. A. B., & Netea, M. G. (2022) · Physiological Reviews · doi:10.1152/physrev.00031.2021 · Cited by 216 · see citing works
Self-citation100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19
Lobo, N., Brooks, N. A., Zlotta, A. R., Cirillo, J. D., Boorjian, S. A., Black, P. C., Meeks, J. J., Bivalacqua, T. J., Gontero, P., Steinberg, G. D., et al. (2021) · Nature Reviews Urology · doi:10.1038/s41585-021-00481-1 · Cited by 152 · see citing works
Rivas, M. N., Ebinger, J. E., Wu, M., Sun, N., Braun, J. G., Sobhani, K., Eyk, J. E. V., Cheng, S. C., & Arditi, M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci145157 · Cited by 152 · see citing works
Trained immunity: General and emerging concepts
Vuscan, P., Kischkel, B., Joosten, L. A. B., & Netea, M. G. (2024) · Immunological Reviews · doi:10.1111/imr.13326 · Cited by 156 · see citing works
Self-citationΤσιλικά, Μ., Taks, E., Dolianitis, K., Kotsaki, A., Leventogiannis, K., Damoulari, C., Kostoula, M., Paneta, M., Adamis, G., Papanikolaou, I. C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.873067 · Cited by 126 · see citing works
Self-citationOptimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game
Palgen, J., Feraoun, Y., Dzangué-Tchoupou, G., Joly, C., Martinon, F., Grand, R. L., & Beignon, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612747 · Cited by 117 · see citing works
Regulating trained immunity with nanomedicine
van Leent, M. M. T., Priem, B., Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Zwolsman, R. C., Beldman, T. J., Netea, M. G., & Mulder, W. J. M. (2022) · Nature Reviews Materials · doi:10.1038/s41578-021-00413-w · Cited by 114 · see citing works
Self-citationZhang, B., Moorlag, S. J. C. F. M., Dominguez-Andres, J., Bulut, O. P., Kilic, G., Liu, Z., van Crevel, R., Xu, C.-J., Joosten, L. A. B., Netea, M. G., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147719 · Cited by 107 · see citing works
Self-citationTrained immunity: Target for prophylaxis and therapy
Ziogas, A., Bruno, M., van der Meel, R., Mulder, W. J. M., & Netea, M. G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.10.015 · Cited by 90 · see citing works
Self-citationCurrent State of the First COVID-19 Vaccines
Prüβ, B. M. (2021) · Vaccines · doi:10.3390/vaccines9010030 · Cited by 85 · see citing works
Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections
Aaby, P., Netea, M. G., & Benn, C. S. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(22)00498-4 · Cited by 86 · see citing works
Self-citationA century of BCG: Impact on tuberculosis control and beyond
Ahmed, A., Rakshit, S., Adiga, V., Dias, M., Dwarkanath, P., D′Souza, G., & Vyakarnam, A. (2021) · Immunological Reviews · doi:10.1111/imr.12968 · Cited by 74 · see citing works
BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases
Singh, A. K., Netea, M. G., & Bishai, W. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148291 · Cited by 76 · see citing works
Self-citationThe BCG Vaccine for COVID-19: First Verdict and Future Directions
González-Pérez, M., Sánchez-Tarjuelo, R., Shor, B., Nistal‐Villán, E., & Ochando, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632478 · Cited by 74 · see citing works
Klinger, D., Hill, B. L., Barda, N., Halperin, E., Gofrit, O. N., Greenblatt, C. L., Rappoport, N., Linial, M., & Bercovier, H. (2021) · Vaccines · doi:10.3390/vaccines9050491 · Cited by 71 · see citing works
Faustman, D. L., Lee, A. J., Hostetter, E. R., Aristarkhova, A., Ng, N., Shpilsky, G. F., Tran, L., Wolfe, G. E., Takahashi, H., Dias, H. F., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100728 · Cited by 71 · see citing works
Principles and Challenges in anti-COVID-19 Vaccine Development
Strizova, Z. O., Smetanová, J., Bartůňková, J., & Milota, T. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000514225 · Cited by 58 · see citing works
Aspatwar, A., Gong, W., Wang, S., Wu, X., & Parkkila, S. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1922685 · Cited by 52 · see citing works
del Fresno, C., García‐Arriaza, J., Martínez-Cano, S., Heras‐Murillo, I., Jarit-Cabanillas, A., Amores-Iniesta, J., Brandi, P., Dunphy, G., Suay‐Corredera, C., Pricolo, M. R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748103 · Cited by 47 · see citing works
BCG vaccination in health care providers and the protection against COVID-19
Netea, M. G., van der Meer, J. W. M., & van Crevel, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci145545 · Cited by 39 · see citing works
Self-citationPittet, L. F., Messina, N. L., Gardiner, K., Orsini, F., Abruzzo, V., Bannister, S., Bonten, M. J. M., Campbell, J., Croda, J., Dalcolmo, M. P., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-052101 · Cited by 40 · see citing works
Self-citationHow could we forget immunometabolism in SARS-CoV2 infection or COVID-19?
Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1840567 · Cited by 39 · see citing works
Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants
Lee, A. W. Q., Wimmers, F., & Pulendran, B. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102189 · Cited by 36 · see citing works
Shifting the Immune Memory Paradigm: Trained Immunity in Viral Infections
Taks, E., Moorlag, S. J. C. F. M., Netea, M. G., & van der Meer, J. W. M. (2022) · Annual Review of Virology · doi:10.1146/annurev-virology-091919-072546 · Cited by 38 · see citing works
Self-citationSingh, S., Saavedra-Ávila, N. A., Tiwari, S., & Porcelli, S. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959656 · Cited by 36 · see citing works
Trained immunity and host‐pathogen interactions
Peignier, A., & Parker, D. (2020) · Cellular Microbiology · doi:10.1111/cmi.13261 · Cited by 36 · see citing works
Sohrabi, Y., dos Santos, J. C., Dorenkamp, M., Findeisen, H. M., Godfrey, R., Netea, M. G., & Joosten, L. A. B. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1228 · Cited by 34 · see citing works
Self-citationTrain the Trainer: Hematopoietic Stem Cell Control of Trained Immunity
Zuani, M. D., & Frič, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827250 · Cited by 34 · see citing works
Muskiet, F. A. J., Carrera‐Bastos, P., Pruimboom, L., Lucía, A., & Furman, D. (2022) · Nutrients · doi:10.3390/nu14071388 · Cited by 34 · see citing works
Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro
Diray‐Arce, J., Angelidou, A., Jensen, K. J., Conti, M. G., Kelly, R. S., Pettengill, M. A., Liu, M., van Haren, S. D., McCulloch, S. D., Michelotti, G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110772 · Cited by 31 · see citing works
Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic
Miteva, D., Peshevska-Sekulovska, M., Snegarova, V., Batselova, H., Alexandrova, R., & Velikova, T. V. (2022) · World Journal of Virology · doi:10.5501/wjv.v11.i5.221 · Cited by 30 · see citing works
Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Kumar, N. C., Dwarkanath, P., Shivalingaiah, S., Rao, S., D′Souza, G., Dias, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.985938 · Cited by 31 · see citing works
Self-citationBindu, S., Dandapat, S., Manikandan, R., Dinesh, M., Anbazhagan, S., Pashupathi, M., Dhawan, M. K., Tiwari, R., Bilal, M., Emran, T. B., et al. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2040238 · Cited by 32 · see citing works
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Pasco, S. T., & Anguíta, J. (2020) · Cells · doi:10.3390/cells9092109 · Cited by 26 · see citing works
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Gong, W., Mao, Y., Li, Y., & Qi, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108870 · Cited by 23 · see citing works
Root-Bernstein, R. S. (2021) · Vaccines · doi:10.3390/vaccines9050474 · Cited by 23 · see citing works
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Madan, M., Baldwa, B., Raja, A., Tyagi, R., Dwivedi, T., Mohan, A., Mittal, S., Madan, K., Hadda, V., Tiwari, P., et al. (2021) · Cureus · doi:10.7759/cureus.19882 · Cited by 22 · see citing works
Velayutham, B., Thiruvengadam, K., Kumaran, P. P., Watson, B., Rajendran, K., & Padmapriyadarsini, C. (2022) · International Journal of Microbiology Research · doi:10.4103/ijmr.ijmr_1540_22 · Cited by 22 · see citing works
On BCG Vaccine Protection from COVID-19: A Review
Bagheri, N., & Montazeri, H. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-00835-1 · Cited by 21 · see citing works
Juste, R. A., Ferreras‐Colino, E., de la Fuente, J., Domínguez, M., Risalde, M. Á., Domı́nguez, L., Cabezas‐Cruz, A., & Gortázar, C. (2022) · Immunology · doi:10.1111/imm.13529 · Cited by 21 · see citing works
Efforts towards a COVID ‐19 vaccine
Brüssow, H. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15225 · Cited by 19 · see citing works
Tarabini, R. F., Rigo, M., Fonseca, A. F., Rubin, F. P., Belle, R. L., Kavraki, L. E., Ferreto, T. C., Antunes, D. A., & de Souza, A. P. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.812176 · Cited by 16 · see citing works
COVID-19 and earlier pandemics, sepsis, and vaccines: A historical perspective
Cavaillon, J.-M., & Osuchowski, M. F. (2021) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2021.04.003 · Cited by 17 · see citing works
The Potential Roles of BCG Vaccine in the Prevention or Treatment of COVID-19
Wang, J., Zhang, Q., Wang, H., & Gong, W. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2705157 · Cited by 14 · see citing works
A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine
Brook, B., Schaltz‐Buchholzer, F., Ben-Othman, R., Kollmann, T. R., & Amenyogbe, N. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.03.092 · Cited by 14 · see citing works
Mathur, S. B., Saxena, R., Pallavi, P., Jain, R., Mishra, D., & Jhamb, U. (2022) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmac056 · Cited by 13 · see citing works
COVID-19 and Beyond: Exploring Public Health Benefits from Non-Specific Effects of BCG Vaccination
Koster, K. J., Webb, H. L., & Cirillo, J. D. (2021) · Microorganisms · doi:10.3390/microorganisms9102120 · Cited by 8 · see citing works
Effect of BCG Vaccination against SARS-CoV-2 Infection
Li, Y.-P., Cai, J.-W., Liao, L.-J., Ding, H., Cao, X.-J., Zhu, G.-D., & Guo, X.-G. (2021) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2021.406 · Cited by 8 · see citing works
Madsen, A. M. R., Gehrt, L., Schaltz‐Buchholzer, F., Möller, S., Christiansen, R., Schellerup, L., Norberg, L. A., Krause, T. G., Nielsen, S., Bliddal, M., et al. (2024) · Journal of Infection · doi:10.1016/j.jinf.2024.106319 · Cited by 7 · see citing works
Self-citationRecent advances in non-specific immune memory against bovine tuberculosis
Blanco, F. C., y García, J. S., & Bigi, F. (2021) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2021.101615 · Cited by 7 · see citing works
Kolla, E., Weill, A., Desplas, D., Semenzato, L., Zureik, M., & Grimaldi‐Bensouda, L. (2022) · Vaccines · doi:10.3390/vaccines10111938 · Cited by 7 · see citing works
Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Kumar, N. C., Shivalingaiah, S., Rao, S., D′Souza, G., Dwarkanath, P., Dias, M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1395683/v1 · Cited by 7 · see citing works
Role of Trained Immunity in Heath and Disease
Das, S., & Lavine, K. J. (2025) · Current Cardiology Reports · doi:10.1007/s11886-024-02167-7 · Cited by 6 · see citing works
Trained immunity in acute and chronic neurological diseases
Zhang, S., & Liesz, A. (2026) · eLife · doi:10.7554/elife.106037 · Cited by 6 · see citing works
Exploring the multifocal therapeutic approaches in COVID-19: A ray of hope
Kumar, A., Dey, A. D., Behl, T., Chadha, S., & Aggarwal, V. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107156 · Cited by 6 · see citing works
Children Naturally Evading COVID-19—Why Children Differ from Adults
Sørensen, C. A., Clemmensen, A., Sparrewath, C., Tetens, M. M., & Krogfelt, K. A. (2022) · COVID · doi:10.3390/covid2030025 · Cited by 6 · see citing works
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination
Bulut, O. P., Kılıç, G., Debisarun, P. A., Röring, R. J., Sun, S. J., Kolkman, M., van Rijssen, E., ten Oever, J., Koenen, H. J. P. M., Barreiro, L. B., et al. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106851 · Cited by 7 · see citing works
Self-citationEffect of BCG on Respiratory Complications Caused by COVID-19: A Scoping Review
da Costa, C. G., Jalalizadeh, M., Yadollahvandmiandoab, R., Buosi, K., & Reis, L. O. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s393861 · Cited by 5 · see citing works
BCG: new life for a centenarian vaccine
Aaby, P., & Benn, C. S. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30714-3 · Cited by 5 · see citing works
Self-citationMultidimensional futuristic approaches to address the pandemics beyond COVID-19
Kotwal, S. B., Orekondey, N., Saradadevi, G. P., Priyadarshini, N., Puppala, N. V., Bhushan, M., Motamarry, S., Kumar, R., Mohannath, G., & Dey, R. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17148 · Cited by 4 · see citing works
Engineering a dual vaccine against COVID-19 and tuberculosis
Guthrie, C. M., Tan, X., Meeker, A. C., Self, A. E., Liu, L., & Cheng, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1273019 · Cited by 4 · see citing works
Mariotti, F., Sponchiado, F., Lagi, F., Moroni, C., Paggi, R., Kiros, S. T., Miele, V., Bartoloni, A., Mencarini, J., & The COCORA Working Group (2023) · Infectious Disease Reports · doi:10.3390/idr15060068 · Cited by 4 · see citing works
Lidenge, S. J., Yalcin, D., Bennett, S. J., Ngalamika, O., Kweyamba, B. B., Mwita, C. J., Tso, F. Y., Mwaiselage, J. D., West, J. T., & Wood, C. A. (2024) · Viruses · doi:10.3390/v16030448 · Cited by 4 · see citing works
Korde, S. B., Pillewan, S. R., Dumbre, S. R., Bandgar, A. R., Shinde, P. S., Gairola, S., & Nikam, V. S. (2024) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2024.103102 · Cited by 4 · see citing works
BCG as an adjunct or alternative vaccine to prevent COVID-19?
Weng, C., & Chan, P. A. (2020) · Journal of Travel Medicine · doi:10.1093/jtm/taaa175 · Cited by 4 · see citing works
Cheap and Commonplace: Making the Case for BCG and γδ T Cells in COVID-19
Morrison, A. L., Sharpe, S. A., White, A., & Bodman‐Smith, M. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.743924 · Cited by 4 · see citing works
Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19
Sharma, A. (2021) · Gene · doi:10.1016/j.gene.2021.145574 · Cited by 5 · see citing works
Campelo, T. A., Oliveira, N. S., Souza, P. F. N., de-Oliveira, D. F. G., Frota, C. C., & Antas, P. R. Z. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2521190 · Cited by 3 · see citing works
Non-specific protection against severe COVID-19 associated to typhoid fever and DTP vaccination
Juste, R. A., Vrotsou, K., Mateo‐Abad, M., Gutiérrez-Stampa, M. A., del Campo, R. R., Vergara, I., & Bujanda, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29935 · Cited by 3 · see citing works
Ramos, R. I., Shaw, M. A., Foshag, L. J., Stern, S. L., Rahimzadeh, N., Elashoff, D. A., & Hoon, D. S. �. (2020) · Cancers · doi:10.3390/cancers13010091 · Cited by 3 · see citing works
Lower SARS-CoV-2 Seroprevalence among Cancer Patients in Sub-Saharan Africa
Tso, F. Y., Lidenge, S. J., Ngowi, J. R., Peña, P. B., Clegg, A. A., Ngalamika, O., Mwita, C. J., Mwaiselage, J. D., & Wood, C. A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154428 · Cited by 3 · see citing works
Алексеенко, И. В., Vasilov, R. G., Kondratyeva, L. G., Kostrov, S. V., Чернов, И. П., & Sverdlov, E. D. (2023) · Russian Journal of Genetics · doi:10.1134/s1022795423090028 · Cited by 3 · see citing works
Induction of Trained Immunity by BCG: Recent Data and Opinions
Алексеенко, И. В., Kondratyeva, L. G., Чернов, И. П., & Sverdlov, E. D. (2024) · Russian Journal of Genetics · doi:10.1134/s1022795424701187 · Cited by 2 · see citing works
Rivas, M. N., Rosser, C. J., & Arditi, M. (2021) · Bladder Cancer · doi:10.3233/blc-201529 · Cited by 2 · see citing works
Ivashkevich, Y. V., Kazacheuskaya, L., Валерьевна, П. А., & Churilov, L. P. (2020) · Juvenis scientia · doi:10.32415/jscientia_2020_6_4_5-29 · Cited by 2 · see citing works
Çocukluk Çağı Aşıları ve Covid-19 Enfeksiyonu
Yaytokgil, Ş. B., & Toyran, M. (2022) · Turkish Journal of Pediatric Disease · doi:10.12956/tchd.884410 · Cited by 2 · see citing works
Vergkizi, S., & Nikolakakis, I. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.10.009 · Cited by 2 · see citing works
Non-Specific Cross Protection of BCG Vaccination in Dairy Calves
López, R., Villarroel, V., Neira, V., Aguayo, C., Saadi, K., Orozco, K., Ábalos, P., & Retamal, P. (2025) · Dairy · doi:10.3390/dairy6050060 · Cited by 2 · see citing works
Rossi, Y. I., Bolner, G., de Oliveira, F. D., Dall’Acqua, J. C., Antunes, V., & Dias, C. A. G. (2025) · International Journal of Epidemiology · doi:10.1093/ije/dyaf186 · Cited by 1 · see citing works
BCG Vaccination Modulates Long-Term TNF-α and sCD40L in COVID-19: An Exploratory Longitudinal Study
Fávero, C., Barbosa, G., Pellegrini, V., Melo, D., Shariat, S. F., Pascoal, L., & Reis, L. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s600024 · Cited by 1 · see citing works
All mycobacteria are inventive, but some are more Daedalean than others
Geluk, A. (2021) · Immunological Reviews · doi:10.1111/imr.12970 · Cited by 1 · see citing works
Is the BCG Vaccine an Answer to Future Pandemic Preparedness?
Khan, N., Rouphael, N., Baden, L. R., & Graciaa, D. S. (2022) · Vaccines · doi:10.3390/vaccines10020201 · Cited by 1 · see citing works
Алексеенко, И. В., Vasilov, R. G., Kondratyeva, L. G., Kostrov, S. V., Чернов, И. П., & Sverdlov, E. D. (2023) · Генетика · doi:10.31857/s0016675823090023 · Cited by 1 · see citing works
Schaltz‐Buchholzer, F., Curtis, N. C., Diacon, A. H., Giamarellos‐Bourboulis, E. J., Kotsaki, A., Madsen, A. M. R., Messina, N. L., Nhamússua, L., Nielsen, S., Pittet, L. F., et al. (2025) · medRxiv · doi:10.1101/2025.11.19.25340570 · Cited by 1 · see citing works
Self-citationChhetri, B., Vamsi, D. K. K., Prakash, B., & Sanjeevi, C. B. (2021) · Advances in Dynamical Systems and Applications · doi:10.37622/adsa/16.1.2021.369-403
BCG VACCINATION STATUS AND EARLY OUTCOME OF COVID 19 : AN OBSERVATIONAL STUDY
Nair, S., Singla, K., Patel, B., Ghanekar, J., & Potdar, P. V. (2022) · Indian Journal Of Applied Research · doi:10.36106/ijar/4202523
Yoshida, K. (2021) · KAGAKU TO SEIBUTSU · doi:10.1271/kagakutoseibutsu.59.110
Ranjan, A., Kumar, P., Verma, M., Singh, C., Pandey, S., Naik, B. N., Nirala, S. K., & Rao, R. (2022) · National Journal of Community Medicine · doi:10.55489/njcm1322022160
Rops, M. A. J., Moorlag, S. J. C. F. M., van Deuren, R. C., Jaeger, M., Joosten, L. A. B., Medici, M., Netea, M. G., Smit, J. W. A., & Netea-Maier, R. T. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000436
Self-citationimpact of Bacillus Calmette-Guérin (BCG) vaccination on the course of COVID-19
Gałązka, J. K. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.10.016
Alavi-Naini, R., Sargolzaie, N., & Metanat, M. (2022) · PubMed Central
Rao, J. (2021) · Open Access Journal of Pharmaceutical Research · doi:10.23880/oajpr-16000234
Bacille Calmette–Guerin Vaccine May Be an Effective Tool for COVID-19 Prevention
Jerath, V. P., Kulkarni, S. V., & Basak, S. (2024) · Indian Journal of Medical Specialities · doi:10.4103/injms.injms_172_23
- Authors
- Moorlag, S. J. C. F. M., van Deuren, R. C., van Werkhoven, C. H., Jaeger, M., Debisarun, P., Taks, E., Mourits, V. P., Koeken, V. A. C. M., de Bree, L. C. J., ten Doesschate, T., Cleophas, M. C., Smeekens, S., Oosting, M., van de Veerdonk, F. L., Joosten, L. A. B., ten Oever, J., van der Meer, J. W. M., Curtis, N., Aaby, P., Stabell-Benn, C., Giamarellos-Bourboulis, E. J., Bonten, M., van Crevel, R., & Netea, M. G.
- Affiliations
- Radboud University Nijmegen (NL)
- Royal Children's Hospital (AU)
- Bandim Health Project (GW)
- Utrecht University (NL)
- University of Bonn (DE)
- Corresponding author
- Netea, Mihai G.
- ORCID
- Venue
- Cell Reports Medicine
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 1
- Issue
- 5
- Pages
- 100073
- ISSN
- 2666-3791 (ISSN-L)
- PMC
- PMC7405881
- OpenAlex
- W3046966157
- Cited by
- 96
- References
- 43
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 33 · 2021: 30 · 2020: 12
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- European Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- BCG vaccination, COVID-19 pandemic, trained immunity, innate immunity, vaccine safety, fatigue, respiratory infections, healthy volunteers
- MeSH terms
- COVID-19, SARS-CoV-2, Adult, Aged, BCG Vaccine, Female, Humans, Immunologic Memory, Male, Middle Aged, Netherlands, Retrospective Studies, Severity of Illness Index, Vaccination, Incidence, Young Adult
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