Cited by 96Immune responses and vaccinationsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

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Moorlag, Simone J.C.F.M., van Deuren, Rosanne C., van Werkhoven, Cornelis H., Jaeger, Martin, Debisarun, Priya, Taks, Esther, Mourits, Vera P., Koeken, Valerie A.C.M. +16 more·2020·Cell Reports Medicine

Abstract

Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection are underway, but concerns have been raised regarding the potential harm of strong innate immune responses. To investigate the safety of BCG vaccination, we retrospectively assessed coronavirus disease 2019 (COVID-19) and related symptoms in three cohorts of healthy volunteers who either received BCG in the last 5 years or did not. BCG vaccination is not associated with increased incidence of symptoms during the COVID-19 outbreak in the Netherlands. Our data suggest that BCG vaccination might be associated with a decrease in the incidence of sickness during the COVID-19 pandemic (adjusted odds ratio [AOR] 0.58, p < 0.05), and lower incidence of extreme fatigue. In conclusion, recent BCG vaccination is safe, and large randomized trials are needed to reveal if BCG reduces the incidence and/or severity of SARS-CoV-2 infection.

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  • Trained immunity is a specialized form of innate immune memory, best characterized for BCG vaccination and β-glucan stimulation.

    “A specialized form of innate immune adaptation is the induction of immune memory (also termed trained immunity)”

    From COVID-19 and the human innate immune system (2021) · cites this paper as Moorlag et al., 2020

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Authors
Moorlag, S. J. C. F. M., van Deuren, R. C., van Werkhoven, C. H., Jaeger, M., Debisarun, P., Taks, E., Mourits, V. P., Koeken, V. A. C. M., de Bree, L. C. J., ten Doesschate, T., Cleophas, M. C., Smeekens, S., Oosting, M., van de Veerdonk, F. L., Joosten, L. A. B., ten Oever, J., van der Meer, J. W. M., Curtis, N., Aaby, P., Stabell-Benn, C., Giamarellos-Bourboulis, E. J., Bonten, M., van Crevel, R., & Netea, M. G.
Affiliations
  • Radboud University Nijmegen (NL)
  • Royal Children's Hospital (AU)
  • Bandim Health Project (GW)
  • Utrecht University (NL)
  • University of Bonn (DE)
Corresponding author
Netea, Mihai G.
Venue
Cell Reports Medicine
Publisher
Elsevier BV
Published
2020-08
Volume
1
Issue
5
Pages
100073
ISSN
2666-3791 (ISSN-L)
OpenAlex
W3046966157
Cited by
96
References
43
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 33 · 2021: 30 · 2020: 12
FWCI
7.09
Type
journal article
Language
en
Open access
Locations
  • Cell Reports Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • European Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
BCG vaccination, COVID-19 pandemic, trained immunity, innate immunity, vaccine safety, fatigue, respiratory infections, healthy volunteers
MeSH terms
COVID-19, SARS-CoV-2, Adult, Aged, BCG Vaccine, Female, Humans, Immunologic Memory, Male, Middle Aged, Netherlands, Retrospective Studies, Severity of Illness Index, Vaccination, Incidence, Young Adult

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