Past, Present, and Future Drug Delivery Systems for Antiretrovirals
Open accessAbstract
The human immunodeficiency virus has infected millions of people and the epidemic continues to grow rapidly in some parts of the world. Antiretroviral (ARV) therapy has provided improved treatment and prolonged the life expectancy of patients. Moreover, there is growing interest in using ARVs to protect against new infections. Hence, ARVs have emerged as our primary strategy in combating the virus. Unfortunately, several challenges limit the optimal performance of these drugs. First, ARVs often require life-long use and complex dosing regimens. This results in low patient adherence and periods of lapsed treatment manifesting in drug resistance. This has prompted the development of alternate dosage forms such as vaginal rings and long-acting injectables that stand to improve patient adherence. Another problem central to therapeutic failure is the inadequate penetration of drugs into infected tissues. This can lead to incomplete treatment, development of resistance, and viral rebound. Several strategies have been developed to improve drug penetration into these drug-free sanctuaries. These include encapsulation of drugs in nanoparticles, use of pharmacokinetic enhancers, and cell-based drug delivery platforms. In this review, we discuss issues surrounding ARV therapy and their impact on drug efficacy. We also describe various drug delivery-based approaches developed to overcome these issues.
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HIV-infected individuals require lifelong treatment to ensure control of the viral burden.
“HIV-infected individuals require lifelong treatment to ensure control of the viral burden 10 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [10]
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Self-citation
- Authors
- Kirtane, A. R., Langer, R., & Traverso, G.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Traverso, Giovanni
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 105
- Issue
- 12
- Pages
- 3471-3482
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2550870951
- Cited by
- 28
- References
- 179
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 2 · 2019: 6 · 2018: 6 · 2017: 5
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pharmaceutical Sciences (acceptedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Bill and Melinda Gates Foundation (OPP1139937)
- NIH (EB-000244)
- Max Planck Research Award, Award Ltr Dtd. 2/11/08, Alexander von Humboldt-Stiftung Foundation
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- antiretroviral drugs, HIV, drug delivery systems, patient adherence, drug resistance, long-acting injectables, vaginal ring, nanoparticle drug encapsulation, cell-based drug delivery, viral rebound
- MeSH terms
- Animals, Contraceptive Devices, Female, Dosage Forms, Forecasting, Humans, HIV Infections, Drug Delivery Systems, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Anti-Retroviral Agents
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