Cited by 28HIV/AIDS drug development and treatmentAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

Past, Present, and Future Drug Delivery Systems for Antiretrovirals

Open access
Kirtane, Ameya R., Langer, Robert, Traverso, Giovanni·2016·Journal of Pharmaceutical Sciences

Abstract

The human immunodeficiency virus has infected millions of people and the epidemic continues to grow rapidly in some parts of the world. Antiretroviral (ARV) therapy has provided improved treatment and prolonged the life expectancy of patients. Moreover, there is growing interest in using ARVs to protect against new infections. Hence, ARVs have emerged as our primary strategy in combating the virus. Unfortunately, several challenges limit the optimal performance of these drugs. First, ARVs often require life-long use and complex dosing regimens. This results in low patient adherence and periods of lapsed treatment manifesting in drug resistance. This has prompted the development of alternate dosage forms such as vaginal rings and long-acting injectables that stand to improve patient adherence. Another problem central to therapeutic failure is the inadequate penetration of drugs into infected tissues. This can lead to incomplete treatment, development of resistance, and viral rebound. Several strategies have been developed to improve drug penetration into these drug-free sanctuaries. These include encapsulation of drugs in nanoparticles, use of pharmacokinetic enhancers, and cell-based drug delivery platforms. In this review, we discuss issues surrounding ARV therapy and their impact on drug efficacy. We also describe various drug delivery-based approaches developed to overcome these issues.

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Crossref · 10.1016/j.xphs.2016.09.015

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176 of 176 references verified0 citation errors · 0 not checkable

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  • HIV-infected individuals require lifelong treatment to ensure control of the viral burden.

    “HIV-infected individuals require lifelong treatment to ensure control of the viral burden 10 .”

    From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [10]

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Authors
Kirtane, A. R., Langer, R., & Traverso, G.
Affiliations
  • Koch Institute for Integrative Cancer Research At MIT (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Traverso, Giovanni
Venue
Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2016-12
Volume
105
Issue
12
Pages
3471-3482
ISSN
0022-3549 (ISSN-L)
OpenAlex
W2550870951
Cited by
28
References
179
Citations by year
2026: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 2 · 2019: 6 · 2018: 6 · 2017: 5
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Pharmaceutical Sciences (acceptedVersion)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
Funders
  • Bill and Melinda Gates Foundation (OPP1139937)
  • NIH (EB-000244)
  • Max Planck Research Award, Award Ltr Dtd. 2/11/08, Alexander von Humboldt-Stiftung Foundation
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
antiretroviral drugs, HIV, drug delivery systems, patient adherence, drug resistance, long-acting injectables, vaginal ring, nanoparticle drug encapsulation, cell-based drug delivery, viral rebound
MeSH terms
Animals, Contraceptive Devices, Female, Dosage Forms, Forecasting, Humans, HIV Infections, Drug Delivery Systems, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Anti-Retroviral Agents

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