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Cell migration: Rho GTPases lead the way
Abstract
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration.
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“A gradient of activity Rac1 is required at the leading edge in migrating cells for F-actin assembly and membrane protrusion.28,29”
From Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells (2008) · cites this paper as [29]
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Metadata
- Authors
- Raftopoulou, M., & Hall, A.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 265
- Issue
- 1
- Pages
- 23-32
- ISSN
- 0012-1606
- Cited by
- 1,235
- References
- 6
- Language
- en
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