NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

Diversity, stability and resilience of the human gut microbiota

Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works

The Inflammasomes

Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

NF-κB regulation in the immune system

Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,115 · see citing works

NF-κB: linking inflammation and immunity to cancer development and progression

Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,114 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

RHO GTPASES: Biochemistry and Biology

Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009 · see citing works

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works

Inflammatory bowel disease

Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · see citing works

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works

Non-canonical inflammasome activation targets caspase-11

Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530 · see citing works

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510 · see citing works

Bifidobacteria can protect from enteropathogenic infection through production of acetate

Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works

Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869 · see citing works

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M., Labigne-Roussel, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,574 · see citing works

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature · doi:10.1038/nature11826 · Cited by 1,555 · see citing works

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452 · see citing works

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452 · see citing works

Cell migration: Rho GTPases lead the way

Raftopoulou, M., & Hall, A. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,444 · see citing works

The gastrointestinal mucus system in health and disease

Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438 · see citing works

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,437 · see citing works

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008072200 · Cited by 1,357 · see citing works

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., et al. (2003) · Nature Immunology · doi:10.1038/ni945 · Cited by 1,323 · see citing works

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288 · see citing works

The intestinal crypt, a prototype stem cell compartment

Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223 · see citing works

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170 · see citing works

The gut microbiota in IBD

Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works

Enteric defensins are essential regulators of intestinal microbial ecology

Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., et al. (2010) · Nature Immunology · doi:10.1038/ni.1825 · Cited by 1,156 · see citing works

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,144 · see citing works

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107 · see citing works

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

Hampe, J., Cuthbert, A. P., Croucher, P. J. P., Mirza, M. M., Mascheretti, S., Fisher, S. A., Frenzel, H., King, K., Hasselmeyer, A., Macpherson, A. J., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05063-7 · Cited by 1,090 · see citing works

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087 · see citing works

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077 · see citing works

Non-Smad TGF-β signals

Moustakas, A., & Heldin, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02554 · Cited by 1,069 · see citing works

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.003 · Cited by 989 · see citing works

The NLR Gene Family: A Standard Nomenclature

Ting, J. P. ‐., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 958 · see citing works

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940 · see citing works

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

Moses, H. L., Yang, E. Y., & Pietenpol, J. A. (1990) · Cell · doi:10.1016/0092-8674(90)90155-8 · Cited by 939 · see citing works

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

Bauer, C. A., Duewell, P., Mayer, C., Lehr, H. A., Fitzgerald, K. A., Dauer, M., Tschopp, J., Endres, S., Latz, E., & Schnurr, M. M. (2010) · Gut · doi:10.1136/gut.2009.197822 · Cited by 918 · see citing works

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Perše, M., & Cerar, A. (2012) · BioMed Research International · doi:10.1155/2012/718617 · Cited by 886 · see citing works

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

Eisenhoffer, G. T., Loftus, P. D., Yoshigi, M., Otsuna, H., Chien, C.-B., Morcos, P. A., & Rosenblatt, J. (2012) · Nature · doi:10.1038/nature10999 · Cited by 876 · see citing works

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis

Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

Allen, I. C., TeKippe, E. M., Woodford, R.-M. T., Uronis, J. M., Holl, E. K., Rogers, A. B., Herfarth, H. H., Jobin, C., & Ting, J. P.-Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100050 · Cited by 826 · see citing works

Structure and Function of the Polymeric Mucins in Airways Mucus

Thornton, D. J., Rousseau, K., & McGuckin, M. A. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100702 · Cited by 824 · see citing works

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2695 · Cited by 805 · see citing works

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

Miao, E. A., Mao, D. P., Yudkovsky, N., Bonneau, R., Lorang, C. G., Warren, S. E., Leaf, I. A., & Aderem, A. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913087107 · Cited by 800 · see citing works

Rho GTPases and the control of cell behaviour

Hall, A. (2005) · Biochemical Society Transactions · doi:10.1042/bst20050891 · Cited by 793 · see citing works

Homeostasis and Inflammation in the Intestine

Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784 · see citing works

Intestinal label-retaining cells are secretory precursors expressing Lgr5

Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature · doi:10.1038/nature11965 · Cited by 761 · see citing works

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708 · see citing works

Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor

Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702 · see citing works

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697 · see citing works

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

Abreu, M. T., Vora, P., Faure, E., Thomas, L. S., Arnold, E. T., & Arditi, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1609 · Cited by 681 · see citing works

Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing

Margadant, C., & Sonnenberg, A. (2010) · The EMBO Reports · doi:10.1038/embor.2009.276 · Cited by 653 · cited 1× · see citing works

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642 · see citing works

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632 · see citing works

Trefoil factors: initiators of mucosal healing

Taupin, D. R., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 625 · see citing works

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

Lee, J., Mo, J., Katakura, K., Alkalay, I., Rucker, A. N., Liu, Y., Lee, H., Shen, C., Cojocaru, G., Shenouda, S., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1500 · Cited by 621 · see citing works

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., & Stappenbeck, T. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405979102 · Cited by 605 · see citing works

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Barrett, J., Lee, J. C., Lees, C., Prescott, N., Anderson, C., Phillips, A., Wesley, E., Parnell, K. S., Zhang, H., Drummond, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.483 · Cited by 602 · see citing works

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works

NLRX1 is a regulator of mitochondrial antiviral immunity

Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 586 · see citing works

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573 · see citing works

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

Couturier-Maillard, A., Sécher, T., Rehman, A., Normand, S., Arcangelis, A. D., Häsler, R., Huot, L., Grandjean, T., Bressenot, A., Delanoye, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62236 · Cited by 571 · see citing works

Nod2 is required for the regulation of commensal microbiota in the intestine

Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564 · see citing works

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., & Núñez, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003415200 · Cited by 538 · see citing works

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

Allen, I. C., Wilson, J. E., Schneider, M., Lich, J. D., Roberts, R. A., Arthur, J. C., Woodford, R.-M. T., Davis, B. K., Uronis, J. M., Herfarth, H. H., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.012 · Cited by 534 · see citing works

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

Park, J., Kim, Y., McDonald, C., Kanneganti, T., Hasegawa, M., Body–Malapel, M., Inohara, N., & Núñez, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2380 · Cited by 532 · see citing works

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

Villani, A., Lemire, M., Fortin, G., Louis, E. J., Silverberg, M. S., Collette, C., Baba, N., Libioulle, C., Bélaïche, J., Bitton, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.285 · Cited by 526 · see citing works

A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Núñez, G., & Inohara, N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601962 · Cited by 520 · see citing works

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517 · see citing works

Impaired Production and Increased Apoptosis of Neutrophils in Granulocyte Colony-Stimulating Factor Receptor–Deficient Mice

Liu, F., Wu, H. Y., Wesselschmidt, R. L., Kornaga, T., & Link, D. C. (1996) · Immunity · doi:10.1016/s1074-7613(00)80504-x · Cited by 510 · see citing works

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

Fukata, M., Michelsen, K. S., Eri, R. D., Thomas, L. S., Hu, B., Lukasek, K., Nast, C. C., Lechago, J., Xu, R., Naiki, Y., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2004 · Cited by 508 · see citing works

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

Molofsky, A. B., Byrne, B. G., Whitfield, N. N., Madigan, C. A., Fuse, E. T., Tateda, K., & Swanson, M. S. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051659 · Cited by 490 · see citing works

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475 · see citing works

Wnt5a Potentiates TGF-β Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

Miyoshi, H., Ajima, R., Luo, C. T., Yamaguchi, T. P., & Stappenbeck, T. S. (2012) · Science · doi:10.1126/science.1223821 · Cited by 470 · see citing works

Molecular analysis of the gut microbiota of identical twins with Crohn's disease

Dicksved, J., Halfvarson, J., Rosenquist, M., Järnerot, G., Tysk, C., Apajalahti, J., Engstrand, L. G., & Jansson, J. K. (2008) · The ISME Journal · doi:10.1038/ismej.2008.37 · Cited by 459 · see citing works

Cox-2 Is Regulated by Toll-Like Receptor-4 (TLR4) Signaling: Role in Proliferation and Apoptosis in the Intestine

Fukata, M., Chen, A., Klepper, A. L., Krishnareddy, S., Vamadevan, A. S., Thomas, L. S., Xu, R., Inoue, H., Arditi, M., Dannenberg, A. J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.017 · Cited by 456 · see citing works

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

Hu, B., Elinav, E., Huber, S., Booth, C. J., Strowig, T., Jin, C., Eisenbarth, S. C., & Flavell, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016814108 · Cited by 452 · see citing works

Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β

Dignass, A. U., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90136-z · Cited by 449 · see citing works

Villin is a major protein of the microvillus cystoskeleton which binds both G and F actin in a calcium-dependent manner

Bretscher, A. P., & Weber, K. K. (1980) · Cell · doi:10.1016/0092-8674(80)90330-x · Cited by 445 · see citing works

Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis

Ogura, Y., Lala, S. G., Xin, W., Smith, E., Dowds, T. A., Chen, F. F., Zimmermann, E., Tretiakova, M., Cho, J. H., Hart, J., et al. (2003) · Gut · doi:10.1136/gut.52.11.1591 · Cited by 439 · see citing works

A functional role for NLRP6 in intestinal inflammation and tumorigenesis

Chen, G. Y., Liu, M., Wang, F., Bertin, J., & Núñez, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100412 · Cited by 436 · see citing works

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

Macpherson, A. J., Khoo, U. Y., Forgács, I., Philpott‐Howard, J., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.3.365 · Cited by 435 · see citing works

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

Hirota, S. A., Ng, J., Lueng, A., Khajah, M. A., Parhar, K. K. S., Li, Y., Lam, V. L., Potentier, M. S., Ng, K., Bawa, M., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21478 · Cited by 434 · see citing works

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut

Melmed, G., Thomas, L. S., Lee, N., Tesfay, S. Y., Lukasek, K., Michelsen, K. S., Zhou, Y., Hu, B., Arditi, M., & Abreu, M. T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1406 · Cited by 431 · see citing works

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18

Salcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R.-M., Wang, E., Ma, W., Haines, D., O'hUigin, C., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100199 · Cited by 429 · see citing works

Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

Marinari, E., Mehonic, A., Curran, S., Gale, J. E., Duke, T. A. J., & Baum, B. (2012) · Nature · doi:10.1038/nature10984 · Cited by 426 · see citing works

TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Rosenstiel, P. C., Fantini, M. C., Bräutigam, K., Waetzig, G., Kuehbacher, T., Seegert, D., & Schreiber, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50157 · Cited by 423 · see citing works

Deletion of TLR5 results in spontaneous colitis in mice

Vijay–Kumar, M., Sanders, C. J., Taylor, R. T., Kumar, A., Aitken, J. D., Sitaraman, S. V., Neish, A. S., Uematsu, S., Akira, S., Williams, I. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33084 · Cited by 420 · see citing works

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

Anand, P., Malireddi, R. K. S., Lukens, J. R., Vogel, P., Bertin, J., Lamkanfi, M., & Kanneganti, T. (2012) · Nature · doi:10.1038/nature11250 · Cited by 414 · see citing works

Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells

Hornef, M. W., Frisan, T., Vandewalle, A., Normark, S. J., & Richter‐Dahlfors, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011788 · Cited by 413 · see citing works

IL-18 production downstream of the NLRP3 inflammasome confers protection against colorectal tumor formation

Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M., & Kanneganti, T.-D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002046 · Cited by 411 · see citing works

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

Zaki, H., Vogel, P., Malireddi, R. K. S., Body–Malapel, M., Anand, P., Bertin, J., Green, D. R., Lamkanfi, M., & Kanneganti, T. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.10.022 · Cited by 410 · see citing works

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

Fordham, R. P., Yui, S., Hannan, N. R. F., Soendergaard, C., Madgwick, A., Schweiger, P. J., Nielsen, O. H., Vallier, L., Pedersen, R. A., Nakamura, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.09.015 · Cited by 397 · see citing works

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

Nell, S., Suerbaum, S., & Josenhans, C. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2403 · Cited by 396 · see citing works

The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Müller, A. J., Heikenwälder, M. F., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1675 · Cited by 394 · see citing works

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Fernandez, E. M., Valenti, V., Rockel, C., Hermann, C., Pot, B., Boneca, I. G., & Grangette, C. (2011) · Gut · doi:10.1136/gut.2010.232918 · Cited by 376 · see citing works

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

Wang, L., Manji, G. A., Grenier, J. M., Al-Garawi, A. A., Merriam, S., Lora, J. M., Geddes, B. J., Briskin, M., DiStefano, P. S., & Bertin, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203915200 · Cited by 371 · see citing works

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

Normand, S., Delanoye, A., Bressenot, A., Huot, L., Grandjean, T., Peyrin‐Biroulet, L., Lemoine, Y., Hot, D., & Chamaillard, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100981108 · Cited by 358 · see citing works

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Franke, A., Balschun, T. C., Karlsen, T. H., Hedderich, J., May, S., Lu, T. T., Schuldt, D., Nikolaus, S., Rosenstiel, P. C., Krawczak, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.148 · Cited by 352 · see citing works

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs

Barker, N., Bartfeld, S., & Clevers, H. C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.016 · Cited by 352 · see citing works

Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut

Ortega-Cava, C. F., Ishihara, S., Rumi, M. A. K., Kawashima, K., Ishimura, N., Kazumori, H., Udagawa, J., Kadowaki, Y., & Kinoshita, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3977 · Cited by 346 · see citing works

VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis

Scaldaferri, F., Vetrano, S., Sans, M., Arena, V., Straface, G., Stigliano, E., Repici, A., Sturm, A., Malesci, A., Panés, J., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.064 · Cited by 342 · see citing works

Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis

Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 342 · see citing works

The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair

Stappenbeck, T. S., & Miyoshi, H. (2009) · Science · doi:10.1126/science.1172687 · Cited by 339 · see citing works

Toll-like receptors in inflammatory bowel diseases: A decade later

Cario, E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21282 · Cited by 339 · see citing works

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Bertrand, M. J. M., Doiron, K., Labbè, K., Korneluk, R. G., Barker, P. A., & Saleh, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.011 · Cited by 338 · see citing works

Epithelial restitution and wound healing in inflammatory bowel disease

Sturm, A., & Dignass, A. U. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.348 · Cited by 334 · see citing works

Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells

Hornef, M. W., Normark, B. H., Vandewalle, A., & Normark, S. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022194 · Cited by 330 · see citing works

Culture-Independent Analyses of Temporal Variation of the Dominant Fecal Microbiota and Targeted Bacterial Subgroups in Crohn's Disease

Scanlan, P. D., Shanahan, F., O'Mahony, C., & Marchesi, J. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00312-06 · Cited by 330 · see citing works

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

Watanabe, T., Asano, N., Murray, P. J., Ozato, K., Tailor, P. B., Fuss, I. J., Kitani, A., & Strober, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33145 · Cited by 326 · see citing works

NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production

Tattoli, I., Carneiro, L. A. M., Jéhanno, M., Magalhaes, J. G., Shu, Y., Philpott, D. J., Arnoult, D., & Girardin, S. E. (2008) · EMBO Reports · doi:10.1038/sj.embor.7401161 · Cited by 321 · see citing works

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

Barker, N., van Oudenaarden, A., & Clevers, H. C. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.09.009 · Cited by 320 · see citing works

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

McGovern, D. P. B., Hysi, P. G., Ahmad, T., van Heel, D. A., Moffatt, M. F., Carey, A. H., Cookson, W., & Jewell, D. P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi135 · Cited by 318 · see citing works

Commensal-Associated Molecular Patterns Induce Selective Toll-Like Receptor-Trafficking from Apical Membrane to Cytoplasmic Compartments in Polarized Intestinal Epithelium

Cario, E., Brown, D., McKee, M. L., Lynch–Devaney, K., Gerken, G., & Podolsky, D. K. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64360-x · Cited by 301 · see citing works

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A. A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03416-6 · Cited by 296 · see citing works

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production

Siegmund, B., Fantuzzi, G., Rieder, F., Gamboni-Robertson, F., Lehr, H.-A., Hartmann, G., Dinarello, C. A., Endres, S., & Eigler, A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1264 · Cited by 289 · see citing works

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition

Barnich, N., Aguirre, J. E., Reinecker, H., Xavier, R. J., & Podolsky, D. K. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502153 · Cited by 289 · see citing works

XIAP mediates NOD signaling via interaction with RIP2

Krieg, A. H., Correa, R. G., Garrison, J. B., Negrate, G. L., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907131106 · Cited by 287 · see citing works

Toll‐like receptors‐2, ‐3 and ‐4 expression patterns on human colon and their regulation by mucosal‐associated bacteria

Furrie, E., Macfarlane, S., Thomson, G., Macfarlane, G. T., & Microbiology & Gut Biology Group, T. T. &. T. B. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02200.x · Cited by 282 · see citing works

Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

Taupin, D. R., Kinoshita, K., & Podolsky, D. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.799 · Cited by 280 · see citing works

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

Morteau, O., Morham, S. G., Sellon, R. K., Dieleman, L. A., Langenbach, R. J., Smithies, O., & Sartor, R. B. (2000) · Journal of Clinical Investigation · doi:10.1172/jci6899 · Cited by 275 · see citing works

Fibroblast growth factors modulate intestinal epithelial cell growth and migration

Dignass, A. U., Tsunekawa, S., & Podolsky, D. K. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90017-5 · Cited by 272 · see citing works

Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen

Newberry, R. D., Stenson, W. F., & Lorenz, R. G. (1999) · Nature Medicine · doi:10.1038/11341 · Cited by 269 · see citing works

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

Housley, R. M., Morris, C. F., Boyle, W., Ring, B. J., Biltz, R., Tarpley, J. E., Aukerman, S. L., Devine, P. L., Whitehead, R., & Pierce, G. F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117524 · Cited by 266 · see citing works

Wound healing of intestinal epithelial cells

Iizuka, M. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i17.2161 · Cited by 266 · see citing works

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

Brown, S. L., Riehl, T. E., Walker, M. R., Geske, M. J., Doherty, J. M., Stenson, W. F., & Stappenbeck, T. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29159 · Cited by 263 · see citing works

Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

Zhernakova, A., Festen, E. A. M., Franke, L., Trynka, G., van Diemen, C. C., Monsuur, A. J., Bevova, M. R., Nijmeijer, R. M., Slot, R. V. ‘., Heijmans, R., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.03.016 · Cited by 262 · see citing works

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2061 · Cited by 261 · see citing works

Regulation of the intestinal epithelial barrier by the apical junctional complex

Laukoetter, M. G., Bruewer, M., & Nusrat, A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000203864.48255.4f · Cited by 256 · see citing works

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

Lochner, M., Ohnmacht, C., Presley, L. L., Bruhns, P., Si‐Tahar, M., Sawa, S., & Eberl, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100052 · Cited by 254 · see citing works

Intestinal antimicrobial peptides during homeostasis, infection, and disease

Muniz, L. R., Knosp, C. A., & Yeretssian, G. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00310 · Cited by 252 · see citing works

Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration

Playford, R. J., Marchbank, T., Chinery, R., Evison, R., Pignatelli, M. N., Boulton, R. A., Thim, L., & Hanby, A. M. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90014-4 · Cited by 247 · see citing works

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

Kim, Y., Kamada, N., Shaw, M. H., Warner, N. E., Chen, G., Franchi, L., & Núñez, G. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.013 · Cited by 242 · see citing works

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

Geddes, K., Rubino, S. J., Magalhaes, J. G., Streutker, C., Bourhis, L. L., Cho, J., Robertson, S. J., Kim, C. J., Kaul, R., Philpott, D. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2391 · Cited by 235 · see citing works

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

Kulkarni, A. B., & Karlsson, S. (1993) · PubMed Central · Cited by 233 · see citing works

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

Podolsky, D. K., Gerken, G., Eyking, A., & Cario, E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.007 · Cited by 231 · see citing works

NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2

Yang, Y., Yin, C., Pandey, A. K., Abbott, D. W., Sassetti, C. M., & Kelliher, M. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703079200 · Cited by 228 · see citing works

Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers

Ciacci, C., Lind, S. E., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90014-4 · Cited by 226 · see citing works

Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways

Cau, J., & Hall, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02385 · Cited by 226 · see citing works

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

Keestra, A. M., Winter, M. G., Auburger, J. J., Fräßle, S. P., Byndloss, M. X., Winter, S., Kim, A., Poon, V., Ravesloot-Chávez, M. M., Waldenmaier, J. F. T., et al. (2013) · Nature · doi:10.1038/nature12025 · Cited by 224 · see citing works

Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

Cohn, S. M., Schloemann, S. R., Tessner, T. G., Seibert, K., & Stenson, W. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119296 · Cited by 223 · see citing works

Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells.

Nusrat, A., Delp, C., & Madara, J. L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115741 · Cited by 222 · see citing works

Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-κB Activation and p52-Dependent Chemokine Expression in Monocytes

Lich, J. D., Williams, K. L., Moore, C. B., Arthur, J. C., Davis, B. K., Taxman, D. J., & Ting, J. P. ‐. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1256 · Cited by 222 · see citing works

The CATERPILLER Protein Monarch-1 Is an Antagonist of Toll-like Receptor-, Tumor Necrosis Factor α-, and Mycobacterium tuberculosis-induced Pro-inflammatory Signals

Williams, K. L., Lich, J. D., Duncan, J. A., REED, W. A., Rallabhandi, P., Moore, C., Kurtz, S. L., Coffield, V. M., Accavitti-Loper, M. A., Su, L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502820200 · Cited by 221 · see citing works

Nucleotide Binding Oligomerization Domain 2 Deficiency Leads to Dysregulated TLR2 Signaling and Induction of Antigen-Specific Colitis

Watanabe, T., Kitani, A., Murray, P. J., Wakatsuki, Y., Fuss, I. J., & Strober, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.018 · Cited by 218 · see citing works

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

Beaudoin, M., Goyette, P., Boucher, G., Lo, K. S., Rivas, M. A., Stevens, C. R., Alikashani, A., Ladouceur, M., Ellinghaus, D., Törkvist, L., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003723 · Cited by 215 · see citing works

F-actin binding and bundling properties of fimbrin, a major cytoskeletal protein of microvillus core filaments.

Glenney, J. R., Kaulfus, P., Matsudaira, P. T., et al. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52543-1 · Cited by 214 · see citing works

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

Sorbara, M. T., Ellison, L. K., Ramjeet, M., Travassos, L. H., Jones, N. L., Girardin, S. E., & Philpott, D. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.013 · Cited by 198 · see citing works

Distinct Pathways of Cell Migration and Antiapoptotic Response to Epithelial Injury: Structure-Function Analysis of Human Intestinal Trefoil Factor

Kinoshita, K., Taupin, D. R., Itoh, H., & Podolsky, D. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4680-4690.2000 · Cited by 198 · see citing works

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

Gibson, D. L., Ma, C., Bergstrom, K., Huang, J. T., Man, C., & Vallance, B. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01071.x · Cited by 195 · see citing works

Transforming Growth Factor-β Mediates Intestinal Healing and Susceptibility to Injury in Vitro and in Vivo Through Epithelial Cells

Beck, P. L., Rosenberg, I. M., Xavier, R. J., Koh, T. J., Wong, J. F., & Podolsky, D. K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63853-9 · Cited by 194 · see citing works

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responsesPreprint

Tigno-Aranjuez, J. T., Asara, J. M., & Abbott, D. W. (2010) · Genes & Development · doi:10.1101/gad.1964410 · Cited by 194 · see citing works

IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium

Egan, L. J., Eckmann, L., Greten, F. R., Chae, S.-W., Li, Z.-W., Myhre, G. M., Robine, S., Karin, M., & Kagnoff, M. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306734101 · Cited by 192 · see citing works

Trefoil peptides

Wong, W., Poulsom, R., & WRIGHT, N. A. (1999) · Gut · doi:10.1136/gut.44.6.890 · Cited by 184 · see citing works

Galectins-3 and -7, but not Galectin-1, Play a Role in Re-epithelialization of Wounds

Cao, Z., Said, N. A., Amin, S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200981200 · Cited by 183 · see citing works

Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

Anderson, C. A., Massey, D. C. O., Barrett, J. C., Prescott, N. J., Tremelling, M., Fisher, S. A., Gwilliam, R., Jacob, J., Nimmo, E. R., Drummond, H. E., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.032 · Cited by 183 · see citing works

IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease

Tremelling, M., Cummings, F. J. R., Fisher, S. A., Mansfield, J. C., Gwilliam, R., Keniry, A., Nimmo, E. R., Drummond, H. E., Onnie, C. M., Prescott, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.051 · Cited by 182 · see citing works

Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein

Dean, P., & Kenny, B. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04308.x · Cited by 181 · see citing works

A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling

McDonald, C., Chen, F. F., Ollendorff, V., Ogura, Y., Marchetto, S., Lécine, P., Borg, J., & Núñez, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508538200 · Cited by 178 · see citing works

Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.

Playford, R. J., Marchbank, T., Goodlad, R. A., Chinery, R., Poulsom, R., & Hanby, A. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2137 · Cited by 172 · see citing works

Peptidoglycan Signaling in Innate Immunity and Inflammatory Disease

McDonald, C., Inohara, N., & Núñez, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500001200 · Cited by 169 · see citing works

Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells

Allez, M., Brimnes, J., Dotan, I., & Mayer, L. (2002) · Gastroenterology · doi:10.1053/gast.2002.36588 · Cited by 167 · see citing works

Rapid barrier restitution in an in vitro model of intestinal epithelial injury.

Moore, R., Carlson, S., & Jl, M. (1989) · PubMed · Cited by 166 · see citing works

Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases

Correa, R. G., Milutinovic, S., & Reed, J. C. (2012) · Bioscience Reports · doi:10.1042/bsr20120055 · Cited by 165 · see citing works

F actin assembly modulated by villin: Ca++-dependent nucleation and capping of the barbed end

Glenney, J. R., Kaulfus, P., & Weber, K. K. (1981) · Cell · doi:10.1016/0092-8674(81)90338-x · Cited by 165 · see citing works

Rho GTPases as Targets of Bacterial Protein Toxins

Aktories, K., Schmidt, G., & Just, I. (2000) · Biological Chemistry · doi:10.1515/bc.2000.054 · Cited by 161 · see citing works

Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I

Ohneda, K., Ulshen, M. H., Fuller, C. R., D'Ercole, A., & Lund, P. K. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024298 · Cited by 158 · see citing works

In Vivo, Villin Is Required for Ca2+-Dependent F-Actin Disruption in Intestinal Brush Borders

Ferrary, É., Cohen‐Tannoudji, M., Pehau‐Arnaudet, G., Lapillonne, A., Athman, R., Ruiz, T., Boulouha, L., Marjou, F. E., Doye, A., Fontaine, J., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.819 · Cited by 156 · see citing works

Role of Inflammasomes in Host Defense against Citrobacter rodentium Infection

Liu, Z., Zaki, H., Vogel, P., Gurung, P., Finlay, B. B., Deng, W., Lamkanfi, M., & Kanneganti, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.358705 · Cited by 152 · see citing works

Contrasting Action of IL-12 and IL-18 in the Development of Dextran Sodium Sulphate Colitis in Mice

Takagi, H., Kanai∥, T., Okazawa, A., Kishi, Y., Sato, T., Takaishi, H., Inoue, N., Ogata, H., Iwao, Y., Hoshino, K., et al. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310004047 · Cited by 151 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

Ratsimandresy, R. A., Indramohan, M., Dorfleutner, A., & Stehlik, C. (2017) · Cellular &amp; Molecular Immunology · doi:10.1038/cmi.2016.35 · Cited by 161 · see citing works

Recent advances in the development of RIPK2 modulators for the treatment of inflammatory diseases

Pham, A.-T., Ghilardi, A. F., & Sun, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1127722 · Cited by 40 · see citing works

Regulation of homeostasis and regeneration in the adult intestinal epithelium by the TGF ‐β superfamily

Fink, M., & Wrana, J. L. (2022) · Developmental Dynamics · doi:10.1002/dvdy.500 · Cited by 28 · see citing works

Long noncoding RNAs in intestinal epithelium homeostasis

Xiao, L., Gorospe, M., & Wang, J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2019 · Cited by 37 · see citing works

Lactobacillus Protects Against S. Typhimurium –Induced Intestinal Inflammation by Determining the Fate of Epithelial Proliferation and Differentiation

Lu, X., Xie, S., Ye, L., Zhu, L., & Yu, Q. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900655 · Cited by 42 · see citing works

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195

Xiao, L., Wu, J., Wang, J., Chung, H. K., Kalakonda, S., Rao, J. N., Gorospe, M., & Wang, J. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.10.009 · Cited by 115 · see citing works

Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium

Chung, H. K., Xiao, L., Han, N., Chen, J., Yao, V., Cairns, C. A., Raufman, B., Rao, J. N., Turner, D. J., Kozar, R. A., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.169716 · Cited by 17 · see citing works