Cited by 1,235

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Cell migration: Rho GTPases lead the way

Raftopoulou, Myrto, Hall, Alan·2004·Developmental Biology

Abstract

Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ydbio.2003.06.003

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 6 references

Research works printed but not linked: 108

  1. Abe, 2000, Vav2 is an activator of Cdc42, Rac1, and RhoA, J. Biol. Chem., 275, 10141, 10.1074/jbc.275.14.10141 · DOI
  2. Ahmed, 2002, GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice, Cancer Res., 62, 7166
  3. Albert, 2000, alphavbeta5 integrin recruits the CrkII–Dock180–rac1 complex for phagocytosis of apoptotic cells, Nat. Cell Biol., 2, 899, 10.1038/35046549 · DOI
  4. Alblas, 2001, Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes, Mol. Biol. Cell, 12, 2137, 10.1091/mbc.12.7.2137 · DOI
  5. Arber, 1998, Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase, Nature, 393, 805, 10.1038/31729 · DOI
  6. Bagrodia, 1999, Pak to the future, Trends Cell Biol., 9, 350, 10.1016/S0962-8924(99)01618-9 · DOI
  7. Bamburg, 2002, ADF/cofilin and actin dynamics in disease. Acting-depolymerizing factor, Trends Cell Biol., 12, 598, 10.1016/S0962-8924(02)02404-2 · DOI
  8. Barrett, 1997, The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation, Cell, 91, 905, 10.1016/S0092-8674(00)80482-1 · DOI
  9. Benard, 1999, Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases, J. Biol. Chem., 274, 13198, 10.1074/jbc.274.19.13198 · DOI · Paper page
  10. Bienz, 2002, The subcellular destinations of APC proteins, Nat. Rev., Mol. Cell Biol., 3, 328, 10.1038/nrm806 · DOI
  11. Bishop, 2000, Rho GTPases and their effector proteins, Biochem. J., 348, 241, 10.1042/bj3480241 · DOI · Paper page
  12. Blanchoin, 2000, Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks, Curr. Biol., 10, 1273, 10.1016/S0960-9822(00)00749-1 · DOI
  13. Bokoch, 1996, Rac GTPase interacts specifically with phosphatidylinositol 3-kinase, Biochem. J., 315, 775, 10.1042/bj3150775 · DOI
  14. Buday, 2002, The Nck family of adapter proteins: regulators of actin cytoskeleton, Cell Signalling, 14, 723, 10.1016/S0898-6568(02)00027-X · DOI
  15. Castrillon, 1994, Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene, Development, 120, 3367, 10.1242/dev.120.12.3367 · DOI
  16. Cheresh, 1999, Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells, J. Cell Biol., 146, 1107, 10.1083/jcb.146.5.1107 · DOI
  17. Cote, 2002, Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity, J. Cell Sci., 115, 4901, 10.1242/jcs.00219 · DOI
  18. Daub, 2001, Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16, J. Biol. Chem., 276, 1677, 10.1074/jbc.C000635200 · DOI
  19. Duchek, 2001, Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis, Science, 291, 131, 10.1126/science.291.5501.131 · DOI
  20. Duchek, 2001, Guidance of cell migration by the Drosophila PDGF/VEGF receptor, Cell, 107, 17, 10.1016/S0092-8674(01)00502-5 · DOI
  21. Edwards, 1999, Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics, Nat. Cell Biol., 1, 253, 10.1038/12963 · DOI
  22. Ellis, 1991, Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans, Genetics, 129, 79, 10.1093/genetics/129.1.79 · DOI
  23. Etienne-Manneville, 2001, Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta, Cell, 106, 489, 10.1016/S0092-8674(01)00471-8 · DOI
  24. Etienne-Manneville, 2002, Rho GTPases in cell biology, Nature, 420, 629, 10.1038/nature01148 · DOI · Paper page
  25. Funamoto, 2002, Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis, Cell, 109, 611, 10.1016/S0092-8674(02)00755-9 · DOI
  26. Genot, 2000, The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase, Mol. Cell. Biol., 20, 5469, 10.1128/MCB.20.15.5469-5478.2000 · DOI
  27. Grunwald, 2002, Axon guidance: receptor complexes and signaling mechanisms, Curr. Opin. Neurobiol., 12, 250, 10.1016/S0959-4388(02)00323-9 · DOI
  28. Gumienny, 2001, CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration, Cell, 107, 27, 10.1016/S0092-8674(01)00520-7 · DOI · Paper page
  29. Gundersen, 2002, Evolutionary conservation of microtubule-capture mechanisms, Nat. Rev., Mol. Cell Biol., 3, 296, 10.1038/nrm777 · DOI
  30. Han, 1998, Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav, Science, 279, 558, 10.1126/science.279.5350.558 · DOI
  31. Hasegawa, 1996, DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane, Mol. Cell. Biol., 16, 1770, 10.1128/MCB.16.4.1770 · DOI
  32. Haugh, 2000, Spatial sensing in fibroblasts mediated by 3′ phosphoinositides, J. Cell Biol., 151, 1269, 10.1083/jcb.151.6.1269 · DOI
  33. Hawkins, 1995, PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase, Curr. Biol., 5, 393, 10.1016/S0960-9822(95)00080-7 · DOI
  34. Hirsch, 2000, Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation, Science, 287, 1049, 10.1126/science.287.5455.1049 · DOI
  35. Iijima, 2002, Tumor suppressor PTEN mediates sensing of chemoattractant gradients, Cell, 109, 599, 10.1016/S0092-8674(02)00745-6 · DOI
  36. Ishizaki, 2001, Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1, Nat. Cell Biol., 3, 8, 10.1038/35050598 · DOI
  37. Jacinto, 2002, Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biology, Dev. Cell, 3, 9, 10.1016/S1534-5807(02)00208-3 · DOI
  38. Jimbo, 2002, Identification of a link between the tumour suppressor APC and the kinesin superfamily, Nat. Cell Biol., 4, 323, 10.1038/ncb779 · DOI
  39. Kawano, 1999, Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo, J. Cell Biol., 147, 1023, 10.1083/jcb.147.5.1023 · DOI
  40. Kawasaki, 2000, Asef, a link between the tumor suppressor APC and G-protein signaling, Science, 289, 1194, 10.1126/science.289.5482.1194 · DOI
  41. Kiosses, 1999, A role for p21-activated kinase in endothelial cell migration, J. Cell Biol., 147, 831, 10.1083/jcb.147.4.831 · DOI
  42. Kiyokawa, 1998, Activation of Rac1 by a Crk SH3-binding protein, DOCK180, Genes Dev., 12, 3331, 10.1101/gad.12.21.3331 · DOI
  43. Klemke, 1998, CAS/Crk coupling serves as a “molecular switch” for induction of cell migration, J. Cell Biol., 140, 961, 10.1083/jcb.140.4.961 · DOI
  44. Koh, 2001, Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles, J. Cell Sci., 114, 4239, 10.1242/jcs.114.23.4239 · DOI
  45. Kraynov, 2000, Localized Rac activation dynamics visualized in living cells, Science, 290, 333, 10.1126/science.290.5490.333 · DOI
  46. Kuntziger, 2001, Stathmin/Op18 phosphorylation is regulated by microtubule assembly, Mol. Biol. Cell, 12, 437, 10.1091/mbc.12.2.437 · DOI
  47. Lehmann, 2001, Cell migration in invertebrates: clues from border and distal tip cells, Curr. Opin. Genet. Dev., 11, 457, 10.1016/S0959-437X(00)00217-3 · DOI
  48. Li, 2000, Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction, Science, 287, 1046, 10.1126/science.287.5455.1046 · DOI
  49. Liu, 2000, Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins, Mol. Cell. Biol., 20, 7160, 10.1128/MCB.20.19.7160-7169.2000 · DOI
  50. Liu, 1998, Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho, Cell Adhes. Commun., 5, 249, 10.3109/15419069809040295 · DOI
  51. Ma, 2002, Cytoplasmic dynein-associated structures move bidirectionally in vivo, J. Cell Sci., 115, 1453, 10.1242/jcs.115.7.1453 · DOI
  52. Maekawa, 1999, Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase, Science, 285, 895, 10.1126/science.285.5429.895 · DOI
  53. Magie, 1999, Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development, Development, 126, 5353, 10.1242/dev.126.23.5353 · DOI
  54. Manabe Ri, 2002, GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration, J. Cell Sci., 115, 1497, 10.1242/jcs.115.7.1497 · DOI
  55. Manser, 1998, PAK kinases are directly coupled to the PIX family of nucleotide exchange factors, Mol. Cell, 1, 183, 10.1016/S1097-2765(00)80019-2 · DOI
  56. Meyer, 2002, Signaling mechanisms that regulate actin-based motility processes in the nervous system, J. Neurochem., 83, 490, 10.1046/j.1471-4159.2002.01185.x · DOI
  57. Michiels, 1997, Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation, J. Cell Biol., 137, 387, 10.1083/jcb.137.2.387 · DOI
  58. Mitchison, 1996, Actin-based cell motility and cell locomotion, Cell, 84, 371, 10.1016/S0092-8674(00)81281-7 · DOI
  59. Moon, 2003, Rho GTPase-activating proteins in cell regulation, Trends Cell Biol., 13, 13, 10.1016/S0962-8924(02)00004-1 · DOI
  60. Nakamura, 2001, Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization, Curr. Biol., 11, 1062, 10.1016/S0960-9822(01)00297-4 · DOI
  61. Nishihara, 2002, DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines, Blood, 100, 3968, 10.1182/blood-2001-11-0032 · DOI · Paper page
  62. Nobes, 1995, Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81, 53, 10.1016/0092-8674(95)90370-4 · DOI
  63. Nobes, 1999, Rho GTPases control polarity, protrusion, and adhesion during cell movement, J. Cell Biol., 144, 1235, 10.1083/jcb.144.6.1235 · DOI
  64. Nobes, 1995, Activation of the small GTP-binding proteins rho and rac by growth factor receptors, J. Cell Sci., 108, 225, 10.1242/jcs.108.1.225 · DOI
  65. Obermeier, 1998, PAK promotes morphological changes by acting upstream of Rac, EMBO J., 17, 4328, 10.1093/emboj/17.15.4328 · DOI
  66. Palazzo, 2001, mDia mediates Rho-regulated formation and orientation of stable microtubules, Nat. Cell Biol., 3, 723, 10.1038/35087035 · DOI
  67. Palazzo, 2001, Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization, Curr. Biol., 11, 1536, 10.1016/S0960-9822(01)00475-4 · DOI
  68. Parent, 1998, G protein signaling events are activated at the leading edge of chemotactic cells, Cell, 95, 81, 10.1016/S0092-8674(00)81784-5 · DOI
  69. Pruyne, 2002, Role of formins in actin assembly: nucleation and barbed-end association, Science, 297, 612, 10.1126/science.1072309 · DOI
  70. Reif, 2002, The CDM protein DOCK2 in lymphocyte migration, Trends Cell Biol., 12, 368, 10.1016/S0962-8924(02)02330-9 · DOI
  71. Reif, 1996, Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways, Curr. Biol., 6, 1445, 10.1016/S0960-9822(96)00749-X · DOI
  72. Ridley, 2001, Rho proteins, PI 3-kinases, and monocyte/macrophage motility, FEBS Lett., 498, 168, 10.1016/S0014-5793(01)02481-4 · DOI
  73. Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7 · DOI
  74. Ridley, 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, 70, 401, 10.1016/0092-8674(92)90164-8 · DOI
  75. Rohatgi, 1999, The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly, Cell, 97, 221, 10.1016/S0092-8674(00)80732-1 · DOI
  76. Rohatgi, 2000, Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate, J. Cell Biol., 150, 1299, 10.1083/jcb.150.6.1299 · DOI
  77. Rohatgi, 2001, Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway, J. Biol. Chem., 276, 26448, 10.1074/jbc.M103856200 · DOI · Paper page
  78. Sachdev, 2002, Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes, J. Biol. Chem., 277, 17638, 10.1074/jbc.M111575200 · DOI
  79. Sagot, 2002, Yeast formins regulate cell polarity by controlling the assembly of actin cables, Nat. Cell Biol., 4, 42, 10.1038/ncb719 · DOI
  80. Sander, 1999, Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior, J. Cell Biol., 147, 1009, 10.1083/jcb.147.5.1009 · DOI
  81. Sanders, 1999, Inhibition of myosin light chain kinase by p21-activated kinase, Science, 283, 2083, 10.1126/science.283.5410.2083 · DOI
  82. Sasaki, 2000, Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration, Science, 287, 1040, 10.1126/science.287.5455.1040 · DOI
  83. Schmidt, 2002, Guanine nucleotide exchange factors for Rho GTPases: turning on the switch, Genes Dev., 16, 1587, 10.1101/gad.1003302 · DOI
  84. Schultz, 1998, SMART, a simple modular architecture research tool: identification of signaling domains, Proc. Natl. Acad. Sci. U. S. A., 95, 5857, 10.1073/pnas.95.11.5857 · DOI
  85. Sells, 1999, p21-Activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts, J. Cell Biol., 145, 837, 10.1083/jcb.145.4.837 · DOI
  86. Sepp, 2003, RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia, Development, 130, 1825, 10.1242/dev.00413 · DOI
  87. Servant, 2000, Polarization of chemoattractant receptor signaling during neutrophil chemotaxis, Science, 287, 1037, 10.1126/science.287.5455.1037 · DOI
  88. Spencer, 2001, A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans, Proc. Natl. Acad. Sci. U. S. A., 30, 30
  89. Stephens, 2002, Roles of PI3Ks in leukocyte chemotaxis and phagocytosis, Curr. Opin. Cell Biol., 14, 203, 10.1016/S0955-0674(02)00311-3 · DOI
  90. Sumi, 2001, Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase, J. Biol. Chem., 276, 670, 10.1074/jbc.M007074200 · DOI
  91. Uehata, 1997, Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension, Nature, 389, 990, 10.1038/40187 · DOI
  92. Vanhaesebroeck, 1999, Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages, Nat. Cell Biol., 1, 69, 10.1038/9045 · DOI
  93. Wang, 2002, Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils, Nat. Cell Biol., 4, 513, 10.1038/ncb810 · DOI
  94. Watanabe, 1999, Cooperation between mDia1 and ROCK in Rho-induced actin reorganization, Nat. Cell Biol., 1, 136, 10.1038/11056 · DOI
  95. Weaver, 2003, Integration of signals to the Arp2/3 complex, Curr. Opin. Cell Biol., 15, 23, 10.1016/S0955-0674(02)00015-7 · DOI
  96. Weiner, 2002, A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity, Nat. Cell Biol., 4, 509, 10.1038/ncb811 · DOI
  97. Welch, 2002, P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac, Cell, 108, 809, 10.1016/S0092-8674(02)00663-3 · DOI
  98. Whitehead, 1995, Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C, J. Biol. Chem., 270, 18388, 10.1074/jbc.270.31.18388 · DOI
  99. Whitehead, 1999, Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation, Mol. Cell. Biol., 19, 7759, 10.1128/MCB.19.11.7759 · DOI
  100. Wittmann, 2001, Cell motility: can Rho GTPases and microtubules point the way?, J. Cell Sci., 114, 3795, 10.1242/jcs.114.21.3795 · DOI
  101. Wu, 1998, C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180, Nature, 392, 501, 10.1038/33163 · DOI
  102. Wu, 2001, C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment, Dev. Cell, 1, 491, 10.1016/S1534-5807(01)00056-9 · DOI
  103. Wu, 2002, Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth, Dev. Biol., 250, 145, 10.1006/dbio.2002.0785 · DOI
  104. Yang, 2000, Profilin enhances Cdc42-induced nucleation of actin polymerization, J. Cell Biol., 150, 1001, 10.1083/jcb.150.5.1001 · DOI
  105. Yoshii, 1999, alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase, Oncogene, 18, 5680, 10.1038/sj.onc.1202936 · DOI
  106. Zheng, 2001, Dbl family guanine nucleotide exchange factors, Trends Biochem. Sci., 26, 724, 10.1016/S0968-0004(01)01973-9 · DOI · Paper page
  107. Zheng, 1994, Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85, J. Biol. Chem., 269, 18727, 10.1016/S0021-9258(17)32226-3 · DOI
  108. Zhou, 2001, The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway, Dev. Cell, 1, 477, 10.1016/S1534-5807(01)00058-2 · DOI

Cited by

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review