The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration
Open accessAbstract
Unlike mammals, teleost fish are able to mount an efficient and robust regenerative response following optic nerve injury. Although it is clear that changes in gene expression accompany axonal regeneration, the extent of this genomic response is not known. To identify genes involved in successful nerve regeneration, we analyzed gene expression in zebrafish retinal ganglion cells (RGCs) regenerating their axons following optic nerve injury. Microarray analysis of RNA isolated by laser capture microdissection from uninjured and 3-day post-optic nerve injured RGCs identified 347 up-regulated and 29 down-regulated genes. Quantitative RT-PCR and in situ hybridization were used to verify the change in expression of 19 genes in this set. Gene ontological analysis of the data set suggests regenerating neurons up-regulate genes associated with RGC development. However, not all regeneration-associated genes are expressed in differentiating RGCs indicating the regeneration is not simply a recapitulation of development. Knockdown of six highly induced regeneration-associated genes identified two, KLF6a and KLF7a, that together were necessary for robust RGC axon re-growth. These results implicate KLF6a and KLF7a as important mediators of optic nerve regeneration and suggest that not all induced genes are essential to mount a regenerative response.
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Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
FISCHER, P., LEHMANN, U., SOBOTA, R. M., SCHMITZ, J., NIEMAND, C., LINNEMANN, S., HAAN, S., BEHRMANN, I., YOSHIMURA, A., JOHNSTON, J. A., et al. (2004) · Biochemical Journal · doi:10.1042/bj20030893 · Cited by 72
Cited by
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
KLF Family Members Regulate Intrinsic Axon Regeneration Ability
Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L. (2009) · Science · doi:10.1126/science.1175737 · Cited by 714
Neuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
Restoring function after spinal cord injury: towards clinical translation of experimental strategies
Ramer, L. M., Ramer, M. S., & Bradbury, E. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 324
Blackmore, M. G., Wang, Z., Lerch, J. K., Motti, D., Zhang, Y. P., Shields, C. B., Lee, J. K., Goldberg, J. L., Lemmon, V. P., & Bixby, J. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120684109 · Cited by 272
Metadata
- Authors
- Veldman, M. B., Bemben, M. A., Thompson, R. C., & Goldman, D.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 312
- Issue
- 2
- Pages
- 596-612
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1991477688
- Cited by
- 174
- References
- 2
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Veldman, M. B., Bemben, M. A., Thompson, R. C., & Goldman, D. (2007). Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. https://doi.org/10.1016/j.ydbio.2007.09.019
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