Cited by 50Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesMemory and Neural Mechanisms

Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex

Open access
Kleen, Jonathan K., Sesqué, Alexandre, Wu, Edie X., Miller, Forrest A., Hernan, Amanda E., Holmes, Gregory L., Scott, Rod C.·2011·Epilepsy & Behavior

Abstract

Early-life seizures (ELS) are associated with long-term behavioral disorders including autism and ADHD, suggesting that frontal lobe structures may be permanently affected. We tested whether ELS produce structural alterations in the prefrontal cortex (PFC) and impair PFC-mediated function using an operant task of behavioral flexibility in rats. Adult rats that had been exposed to 75 flurothyl seizures during postnatal days 1-10 showed decreased behavioral flexibility in the task compared to controls over multiple behavioral sessions, measured as a lever preference asymmetry (p<0.001) and a decreased efficiency of attaining food rewards (p<0.05). ELS rats also showed an increased thickness of the PFC (p<0.01), primarily attributed to layer V (p<0.01) with no differences in cell density. These structural changes correlated with lever preference behavioral impairments (p<0.05). This study demonstrates that the consequences of ELS extend to the PFC, which may help explain the high prevalence of comorbid behavioral disorders following ELS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.yebeh.2011.07.022

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • FLE seizures can cause structural and functional damage of the prefrontal areas including altered short-term plasticity.

    “And eventually the FLE seizures can cause structural and functional damage of the prefrontal areas including altered short-term plasticity [389, 390].”

    From Development of prefrontal cortex (2022) · cites this paper as [389]

    The Abstract reports increased prefrontal-cortex thickness and impaired PFC-mediated behavioral flexibility after early-life seizures in rats. It does not establish this for frontal lobe epilepsy (FLE) seizures or report altered short-term plasticity; the Discussion says the mechanism of PFC functional alteration requires further study. Page numbers are unavailable in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kleen, J. K., Sesqué, A., Wu, E. X., Miller, F. A., Hernan, A. E., Holmes, G. L., & Scott, R. C.
Affiliations
  • Dartmouth College (US)
  • Université Jean Monnet (FR)
Venue
Epilepsy & Behavior
Publisher
Elsevier BV
Published
2011-10
Volume
22
Issue
2
Pages
214-219
ISSN
1525-5050 (ISSN-L)
OpenAlex
W2082813494
Cited by
50
References
39
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 3
FWCI
2.64
Type
journal article
Language
en
Open access
Locations
  • Epilepsy & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institutes of Health (F30NS064624, R01NS044295)
  • Great Ormond Street Children's Charity
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
early-life seizures, prefrontal cortex, flurothyl-induced seizures, behavioral flexibility, cortical thickness, layer V, autism spectrum disorder, attention deficit hyperactivity disorder
MeSH terms
Animals, Animals, Newborn, Conditioning, Operant, Disease Models, Animal, Electroencephalography, Flurothyl, Male, Seizures, Rats, Sprague-Dawley, Prefrontal Cortex, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review