Stress, epilepsy, and psychiatric comorbidity: How can animal models inform the clinic?

Jones, Nigel C.; O'Brien, Terence J.

doi:10.1016/j.yebeh.2012.09.002

Cited by 44Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeuroscience and Neuropharmacology Research

Stress, epilepsy, and psychiatric comorbidity: How can animal models inform the clinic?

Jones, Nigel C., O'Brien, Terence J.·2013·Epilepsy & Behavior

DOI 10.1016/j.yebeh.2012.09.002

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Abstract

Psychiatric complaints afflict many patients with epilepsy, and these contribute significantly to the impaired quality of life experienced by sufferers of this common group of neurological conditions. Psychiatric disorders in epilepsy patients are under-diagnosed and under-treated. Moreover, evidence suggests that the psychiatric disorders may act as risk factors for some types of epilepsy and exacerbate disease progression in established cases, promoting the case for a bidirectional relationship between epilepsy and psychopathology. While cause and effect relationships can be difficult to establish in human studies, appropriate animal models provide valuable tools with which to study the interactions between epilepsy and stress-related disorders. Indeed, many epilepsy models exhibit behavioral phenotypes which are reflective of psychiatric disorders, and, conversely, stressful environments appear to promote a vulnerability to developing epilepsy. This review summarizes this research area, exploring the behavioral phenotypes in animal models of epilepsy and then examining the influence of stressful environments on susceptibility to seizures and epilepsy. The ultimate goal of this line of research is to be able to translate these findings to humans. Understanding the relationships between epilepsy and associated psychiatric disorders will facilitate effective treatment of mood disorders in epilepsy, inform about the pathophysiology of each individually, and potentially open up novel therapeutic disease-modifying strategies for patients with epilepsy.

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Both population-based and experimental studies in human and animal models have demonstrated a robust relationship between seizures and psychiatric disorders.
“Both population-based and experimental studies in human and animal models have demonstrated a robust relationship between seizures and psychiatric disorders.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [13]

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Dopamine-dependent nature of depression-like behavior in WAG/Rij rats with genetic absence epilepsy
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Stress, glucocorticoids and absences in a genetic epilepsy model
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Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures
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Authors: Jones, N. C., & O'Brien, T. J.
Affiliations: The Royal Melbourne Hospital (AU)
Corresponding author: Jones, Nigel C.
ORCID: Jones, Nigel C.
O'Brien, Terence J.
Venue: Epilepsy & Behavior
Publisher: Elsevier BV
Published: 2013-03
Volume: 26
Issue: 3
Pages: 363-369
ISSN: 1525-5050 (ISSN-L)
DOI: 10.1016/j.yebeh.2012.09.002
OpenAlex: W2086067719
Cited by: 44
References: 126
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 1 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
FWCI: 0.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Epilepsy & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: epilepsy, psychiatric comorbidity, stress, animal models of epilepsy, behavioral phenotypes, mood disorders, seizure susceptibility, disease-modifying therapy, quality of life
MeSH terms: Animals, Mental Disorders, Disease Models, Animal, Epilepsy, Humans, Stress, Psychological, Comorbidity

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Stress, epilepsy, and psychiatric comorbidity: How can animal models inform the clinic?

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