Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1

Yoshimura, Hitoshi; Tada, Tomoko; Iida, Hidetoshi

doi:10.1016/j.yexcr.2003.09.020

Cited by 45Ion Channels and ReceptorsIon channel regulation and functionCalcium signaling and nucleotide metabolism

Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1

Yoshimura, Hitoshi, Tada, Tomoko, Iida, Hidetoshi·2004·Experimental Cell Research

DOI 10.1016/j.yexcr.2003.09.020

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Abstract

The yeast Mid1 protein with an apparent molecular mass of 100 kDa is required for Ca2+ influx stimulated by the mating pheromone and by a capacitative calcium entrylike mechanism acting in response to Ca2+ depletion from the endoplasmic reticulum (ER) and functions as a stretch-activated Ca2+ -permeable channel when expressed in mammalian cells. Our previous work with protease protection experiments has indicated that Mid1 is present in the plasma membrane. In this study, we examined a possible intracellular localization of this protein by indirect fluorescence microscopy and found that Mid1 is present in the ER membrane as well as the plasma membrane. Intracellular fluorescence images for Mid1 were the same as those for the ER marker protein Sec71 but quite different from those of the Golgi protein Ypt1. The results were confirmed by membrane fractionation using Angiografin density gradient analysis. We also investigated the oligomeric structures and protein levels of Mid1 and found that Mid1 forms a 200-kDa oligomer by disulfide bonding. The protein level and modification of Mid1 in the plasma membrane and the ER membrane were unchanged by the mating pheromone. These findings provide new insight into the function of Mid1 in relation to localization, modification, and activation mechanisms.

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Under nonreducing conditions, two distinct Mid1 protein bands were detected: a 100 kDa monomer and a 200 kDa likely complex.
“The 100 kDa band represented the Mid1 monomer, and the 200 kDa band likely corresponded to a Mid1 complex (Fig. 1C) (40).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [40]
Mid1 likely forms an oligomer through sulfide bonding similar to Mid1 in yeast.
“This result suggested that Mid1 likely forms an oligomer through sulfide bonding similar to Mid1 in yeast (40).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [40]

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,685 · see citing works
Methods in yeast genetics
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,543 · see citing works
Methods in Yeast Genetics
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911 · see citing works
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
Gietz, R. D., & Sugino, A. (1988) · Gene · doi:10.1016/0378-1119(88)90185-0 · Cited by 2,901 · see citing works
Short protocols in molecular biology
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80799-6 · Cited by 1,650 · see citing works
Molecular Basis of Mechanotransduction in Living Cells
Hamill, O. P., & Martinac, B. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.685 · Cited by 1,124 · see citing works
[40] Immunofluorescence methods for yeast
Pringle, J. R., Adams, A. E. M., Drubin, D. G., & Haarer, B. K. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94043-c · Cited by 704 · see citing works
Calcium/calmodulin-dependent and -independent phytochrome signal transduction pathways
Neuhaus, G., Bowler, C., Kern, R., & Chua, N. (1993) · Cell · doi:10.1016/0092-8674(93)90272-r · Cited by 473 · see citing works
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
Goodman, M. B., Ernstrom, G. G., Chelur, D. S., O’Hagan, R., Yao, C. A., & Chalfie, M. (2002) · Nature · doi:10.1038/4151039a · Cited by 321 · see citing works
MECHANOSENSITIVE CHANNELS OFESCHERICHIA COLI:The MscL Gene, Protein, and Activities
Sukharev, S., Blount, P., Martinac, B., & Kung, C. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.633 · Cited by 299 · see citing works
Essential role of calcineurin in response to endoplasmic reticulum stress
Bonilla, M., Nastase, K. K., & Cunningham, K. W. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2343 · Cited by 255 · see citing works
MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS
Tavernarakis, N., & Driscoll, M. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.659 · Cited by 234 · see citing works
Review of Mechanosensitive Channels
Sackin, H. (1995) · Annual Review of Physiology · doi:10.1146/annurev.physiol.57.1.333 · Cited by 225 · see citing works
Essential role for induced Ca2+ influx followed by [Ca2+]i rise in maintaining viability of yeast cells late in the mating pheromone response pathway. A study of [Ca2+]i in single Saccharomyces cerevisiae cells with imaging of fura-2.
Iida, H., Yagawa, Y., & Anraku, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38311-5 · Cited by 224 · see citing works
Self-citation
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.
Iida, H., Nakamura, H., Ono, T., Okumura, M. S., & Anraku, Y. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8259 · Cited by 218 · see citing works
Self-citation
Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel
Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H. (1999) · Science · doi:10.1126/science.285.5429.882 · Cited by 213 · see citing works
Self-citation
Cytoplasmic Free Ca2+ in Arabidopsis Roots Changes in Response to Touch but Not Gravity
Legué, V., Blancaflor, E. B., Wymer, C. L., Perbal, G., Fantin, D., & Gilroy, S. (1997) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.3.789 · Cited by 212 · see citing works
A Homolog of Voltage-Gated Ca 2+ Channels Stimulated by Depletion of Secretory Ca 2+ in Yeast
Locke, E. G., Bonilla, M., Liang, L., Takita, Y., & Cunningham, K. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6686-6694.2000 · Cited by 212 · see citing works
Yeast heat-shock protein of Mr 48,000 is an isoprotein of enolase
Iida, H., & Yahara, I. (1985) · Nature · doi:10.1038/315688a0 · Cited by 207 · see citing works
Self-citation
Mechanosensitive channels.
Sackin, H. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002001 · Cited by 201 · see citing works
A Homolog of Mammalian, Voltage-Gated Calcium Channels Mediates Yeast Pheromone-Stimulated Ca 2+ Uptake and Exacerbates the cdc1 (Ts) Growth Defect
Paidhungat, M., & Garrett, S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6339 · Cited by 191 · see citing works
The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating
Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01466-x · Cited by 185 · see citing works
Mechanotransduction
French, A. S. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.001031 · Cited by 183 · see citing works
THE MOLECULES OF MECHANOSENSATION
Garcı́a-Añoveros, J., & Corey, D. P. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.567 · Cited by 177 · see citing works
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
Chelur, D. S., Ernstrom, G. G., Goodman, M. B., Yao, C., Chen, L., O’Hagan, R., & Chalfie, M. (2002) · Nature · doi:10.1038/nature01205 · Cited by 164 · see citing works
Phototropism and geotropism in maize coleoptiles are spatially correlated with increases in cytosolic free calcium
Gehring, C., Williams, D. A., Cody, S. H., & Parish, R. W. (1990) · Nature · doi:10.1038/345528a0 · Cited by 158 · see citing works
A membrane fusion strategy for single‐channel recordings of membranes usually non‐accessible to patch‐clamp pipette electrodes
Criado, M., & Keller, B. U. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80442-8 · Cited by 156 · see citing works
An osmotically induced cytosolic Ca2+ transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance of Saccharomyces cerevisiae
Matsumoto, T. K., Ellsmore, A. J., Cessna, S. G., Low, P. S., Pardo, J. M., Bressan, R. A., & Hasegawa, P. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205037200 · Cited by 155 · see citing works
Mediation of the Attachment or Fusion Step in Vesicular Transport by the GTP-Binding Ypt1 Protein
Segev, N. (1991) · Science · doi:10.1126/science.1904626 · Cited by 154 · see citing works
Gadolinium‐sensitive, voltage‐dependent calcium release channels in the endoplasmic reticulum of a higher plant mechanoreceptor organ.
Klüsener, B., Boheim, G., Liss, H., Engelberth, J., & Weiler, E. W. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07271.x · Cited by 147 · see citing works
Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.
Schandel, K. A., & Jenness, D. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7245 · Cited by 143 · see citing works
Steady‐state free Ca2+ in the yeast endoplasmic reticulum reaches only 10 μM and is mainly controlled by the secretory pathway pump Pmr1
Strayle, J., Pozzan, T., & Rudolph, H. K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4733 · Cited by 134 · see citing works
Differential Regulation of Two Ca2+ Influx Systems by Pheromone Signaling in Saccharomyces cerevisiae
Muller, E. M., Locke, E., & Cunningham, K. W. (2001) · Genetics · doi:10.1093/genetics/159.4.1527 · Cited by 133 · see citing works
Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system.
Nakajima‐Shimada, J., Iida, H., Tsuji, F. I., & Anraku, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6878 · Cited by 122 · see citing works
Self-citation
Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins
Sato, K., Sato, M., & Nakano, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9693 · Cited by 104 · see citing works
Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p.
Sato, K., Nishikawa, S., & Nakano, A. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.11.1459 · Cited by 104 · see citing works
Amiodarone induces a caffeine‐inhibited, MID1‐depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae
Courchesne, W. E., & Ozturk, S. B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03291.x · Cited by 79 · see citing works
Specific induction of Ca2+ transport activity in MATa cells of Saccharomyces cerevisiae by a mating pheromone, alpha factor.
Ohsumi, Y., & Anraku, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85109-8 · Cited by 75 · see citing works
Single channel recordings of reconstituted ion channel proteins: an improved technique
Keller, B. U., Hedrich, R., Vaz, W. L. C., & Criado, M. (1988) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581652 · Cited by 63 · see citing works
Erratum: corrigendum: MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
Goodman, M. B., Ernstrom, G. G., Chelur, D. S., O’Hagan, R., Yao, C. A., & Chalfie, M. (2002) · Nature · doi:10.1038/nature00853 · Cited by 50 · see citing works
Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.
Kurihara, T., & Silver, P. A. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.9.919 · Cited by 45 · see citing works
Anion channels in giant liposomes made of endoplasmic reticulum vesicles from rat exocrine pancreas
Schmid, A., Gögelein, H., Kemmer, T. P., & Schulz, I. (1988) · The Journal of Membrane Biology · doi:10.1007/bf01872329 · Cited by 44 · see citing works
Hexose phosphorylation and the putative calcium channel component Mid1p are required for the hexose‐induced transient elevation of cytosolic calcium response in Saccharomyces cerevisiae
Tökés‐Füzesi, M., Bedwell, D. M., Repa, I., Sipos, K., Sümegi, B., Rab, A., & Miseta, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02956.x · Cited by 40 · see citing works
Molecular Dissection of the Hydrophobic Segments H3 and H4 of the Yeast Ca2+ Channel Component Mid1
Tada, T., Ohmori, M., & Iida, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206993200 · Cited by 28 · see citing works
Self-citation
Epitope mapping and accessibility of immunodominant regions of yeast plasma membrane H+‐ATPase
Serrano, R., Monk, B. C., Villalba, J. M., Montesinos, C., & Weiler, E. W. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17712.x · Cited by 28 · see citing works
Modulation of the ER Ca2+ channel BCC1 from tendrils of Bryonia dioica by divalent cations, protons and H2O2
Klüsener, B., Boheim, G., & Weiler, E. W. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00364-5 · Cited by 24 · see citing works
The Polarity of Statocytes and the Gravisensitivity of Roots are Dependent on the Concentration of Calcium in Statocytes
Wendt, M., & Sievers, A. (1989) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a077827 · Cited by 24 · see citing works
Transformation of Lithium-Treated Yeast Cells and the Selection of Auxotrophic and Dominant Markers
Mount, R. C., Jordan, B. E., & Hadfield, C. (2003) · Humana Press eBooks · doi:10.1385/0-89603-319-8:139 · Cited by 23 · see citing works
Essential Hydrophilic Carboxyl-terminal Regions Including Cysteine Residues of the Yeast Stretch-activated Calcium-permeable Channel Mid1
Maruoka, T., Nagasoe, Y., Inoue, S., Mori, Y., Goto, J., Ikeda, M., & Iida, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111603200 · Cited by 19 · see citing works
Self-citation
Report Clarification
Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H. (2000) · Science · doi:10.1126/science.288.5470.1347 · Cited by 18 · see citing works
Self-citation

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Nguyen, Q. B., Kadotani, N., Kasahara, S., Tosa, Y., MAYAMA, S., & Nakayashiki, H. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06242.x · Cited by 218 · see citing works
Statolith Sedimentation Kinetics and Force Transduction to the Cortical Endoplasmic Reticulum in Gravity-Sensing Arabidopsis Columella Cells
Leitz, G., Kang, B., Schoenwaelder, M. E. A., & Staehelin, L. A. (2009) · The Plant Cell · doi:10.1105/tpc.108.065052 · Cited by 182 · see citing works
A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, and Saccharomyces cerevisiae
Zelter, A., Benčina, M., Bowman, B. J., Yarden, O., & Read, N. D. (2004) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2004.05.001 · Cited by 129 · see citing works
Cell Death Suppressor Arabidopsis Bax Inhibitor-1 Is Associated with Calmodulin Binding and Ion Homeostasis
Ihara‐Ohori, Y., Nagano, M., Muto, S., Uchimiya, H., & Kawai‐Yamada, M. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.090878 · Cited by 108 · see citing works
Calcium Transport Proteins in Fungi: The Phylogenetic Diversity of Their Relevance for Growth, Virulence, and Stress Resistance
Lange, M., & Peiter, E. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03100 · Cited by 90 · see citing works
Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae
Popa, C., Dumitru, I., Ruta, L. L., Danet, A. F., & FARCASANU, I. C. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07794.x · Cited by 67 · see citing works
Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress‐mediated mitochondrial apoptosis in budding yeast
Kajiwara, K., Muneoka, T., Watanabe, Y., Karashima, T., Kitagaki, H., & Funato, K. (2012) · Molecular Microbiology · doi:10.1111/mmi.12056 · Cited by 62 · see citing works
Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress
Hong, M.-P., Vu, K., Bautos, J., & Gelli, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056218 · Cited by 54 · see citing works
Mid1, a Mechanosensitive Calcium Ion Channel, Affects Growth, Development, and Ascospore Discharge in the Filamentous Fungus Gibberella zeae
Cavinder, B., Hamam, A. M., Lew, R. R., & Trail, F. (2011) · Eukaryotic Cell · doi:10.1128/ec.00235-10 · Cited by 53 · see citing works
Glucose-induced calcium influx in budding yeast involves a novel calcium transport system and can activate calcineurin
Groppi, S., Belotti, F., Brandão, R. L., Martegani, E., & Tisi, R. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.03.006 · Cited by 49 · see citing works
Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals
Ghezzi, A., Liebeskind, B. J., Thompson, A., Atkinson, N. S., & Zakon, H. H. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00015 · Cited by 40 · see citing works
A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species
Benčina, M., Bagar, T., Lah, L., & Kraševec, N. (2009) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.07.019 · Cited by 38 · see citing works
Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane
Rigamonti, M., Groppi, S., Belotti, F., Ambrosini, R., Filippi, G., Martegani, E., & Tisi, R. (2015) · Cell Calcium · doi:10.1016/j.ceca.2014.12.003 · Cited by 34 · see citing works
Molecular cloning in yeast by in vivo homologous recombination of the yeast putative α1 subunit of the voltage‐gated calcium channel
Iida, K., Tada, T., & Iida, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.021 · Cited by 35 · see citing works
Self-citation
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Carbó, N., Tarkowski, N., Ipiña, E. P., Dawson, S. P., & Aguilar, P. S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0481 · Cited by 34 · see citing works
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Espeso, E. A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-25304-6_7 · Cited by 33 · see citing works
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Harren, K., & Tudzynski, B. (2013) · Eukaryotic Cell · doi:10.1128/ec.00338-12 · Cited by 31 · see citing works
Fig1 Facilitates Calcium Influx and Localizes to Membranes Destined To Undergo Fusion during Mating in Candida albicans
Yang, M., Brand, A., Srikantha, T., Daniels, K. J., Soll, D. R., & Gow, N. A. R. (2011) · Eukaryotic Cell · doi:10.1128/ec.00145-10 · Cited by 30 · see citing works
Origins of learned reciprocity in solitary ciliates searching grouped ‘courting’ assurances at quantum efficiencies
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宮脇, 千., Moriya, Y., Tatsumi, H., Iida, H., & Sokabe, M. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.014 · Cited by 17 · see citing works
Self-citation
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Self-citation
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Self-citation
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Authors: Yoshimura, H., Tada, T., & Iida, H.
Affiliations: Tokyo Gakugei University (JP)
Corresponding author: Iida, Hidetoshi
ORCID: Yoshimura, Hitoshi
Iida, Hidetoshi
Venue: Experimental Cell Research
Publisher: Elsevier BV
Published: 2004-02
Volume: 293
Issue: 2
Pages: 185-195
ISSN: 0014-4827 (ISSN-L)
DOI: 10.1016/j.yexcr.2003.09.020
OpenAlex: W2078785949
Cited by: 45
References: 55
Citations by year: 2026: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
FWCI: 1.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Cell Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: MID1, stretch-activated calcium channels, subcellular localization, oligomeric structure, disulfide bonds, endoplasmic reticulum membrane, plasma membrane, store-operated calcium entry, mating pheromone, yeast, Saccharomyces cerevisiae, protein modification
MeSH terms: Cell Membrane, Cells, Cultured, Disulfides, Endoplasmic Reticulum, Intracellular Membranes, Membrane Glycoproteins, Pheromones, Polymers, Saccharomyces cerevisiae, Calcium Channels, Calcium Signaling, rab GTP-Binding Proteins, Protein Structure, Quaternary, Saccharomyces cerevisiae Proteins

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Subcellular localization and oligomeric structure of the yeast putative stretch-activated Ca2+ channel component Mid1

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