The Saccharomyces cerevisiae CCH1 gene is involved in calcium influx and mating
Abstract
The yeast Saccharomyces cerevisiae gene CCH1 (ORF YGR217w) shows high homology with animal calcium channel α1‐subunit genes. Knock‐out mutants were constructed of Cch1 and of Mid1 which is known to mediate Ca 2+ influx in response to the α‐mating pheromone. Cch1 is involved in calcium influx and the late stage of the mating process. The cch1 mutant sensitivity against the α‐mating pheromone can be reduced by the addition of extra calcium. The product of this gene is likely to interact with the MID1 gene product in Ca influx or its control.
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Previous genetic data demonstrated identical phenotypic defects of strains lacking either Mid1 or Cch1, including nonviability in low [Ca2+] medium.
“This is consistent with previous genetic data that demonstrated identical phenotypic defects of strains lacking either Mid1 or Cch1 including nonviability in low [Ca 2ϩ ] medium (7,11,15,20).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [11]
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Carbó, N., Tarkowski, N., Ipiña, E. P., Dawson, S. P., & Aguilar, P. S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0481 · Cited by 34 · see citing works
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Harren, K., & Tudzynski, B. (2013) · Eukaryotic Cell · doi:10.1128/ec.00338-12 · Cited by 31 · see citing works
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Antihypertensive, Amlodipine Besilate Inhibits Growth and Biofilm of Human Fungal Pathogen Candida
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Ethanol induces calcium influx via the Cch1-Mid1 transporter in Saccharomyces cerevisiae
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Molecular Dissection of the Hydrophobic Segments H3 and H4 of the Yeast Ca2+ Channel Component Mid1
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Ca2+ homeostasis in the budding yeast Saccharomyces cerevisiae: Impact of ER/Golgi Ca2+ storage
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- Authors
- Fischer, M., Schnell, N., Chattaway, J., Davies, P., Dixon, G., & Sanders, D.
- Affiliations
- University of York (GB)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-12-15
- Volume
- 419
- Issue
- 2-3
- Pages
- 259-262
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2155529170
- Cited by
- 185
- References
- 17
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 11 · 2012: 12
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- Saccharomyces cerevisiae, calcium influx, mating, MID1, knockout mutants, pheromone sensitivity, calcium-dependent signaling
- MeSH terms
- Base Sequence, Calcium, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Saccharomyces cerevisiae, Calcium Channels, Ion Transport, Saccharomyces cerevisiae Proteins
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