Myotube formation is affected by adipogenic lineage cells in a cell-to-Cell contact-independent manner
Abstract
Intramuscular adipose tissue (IMAT) formation is observed in some pathological conditions such as Duchenne muscular dystrophy (DMD) and sarcopenia. Several studies have suggested that IMAT formation is not only negatively correlated with skeletal muscle mass but also causes decreased muscle contraction in sarcopenia. In the present study, we examined w hether adipocytes affect myogenesis. For this purpose, skeletal muscle progenitor cells were transfected with siRNA of PPARγ (siPPARγ) in an attempt to inhibit adipogenesis. Myosin heavy chain (MHC)-positive myotube formation was promoted in cells transfected with siPPARγ compared to that of cells transfected with control siRNA. To determine whether direct cell-to-cell contact between adipocytes and myoblasts is a prerequisite for adipocytes to affect myogenesis, skeletal muscle progenitor cells were cocultured with pre- or mature adipocytes in a Transwell coculture system. MHC-positive myotube formation was inhibited when skeletal muscle progenitor cells were cocultured with mature adipocytes, but was promoted when they were cocultured with preadipocytes. Similar effects were observed when pre- or mature adipocyte-conditioned medium was used. These results indicate that preadipocytes play an important role in maintaining skeletal muscle mass by promoting myogenesis; once differentiated, the resulting mature adipocytes negatively affect myogenesis, leading to the muscle deterioration observed in skeletal muscle pathologies.
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In-vitro studies showed that the coculture of mature adipocytes and skeletal muscle progenitor cells led to a reduction of nuclei number in myosin heavy chain (MHC)-positive myotubes.
“In-vitro studies showed that the coculture of mature adipocytes and skeletal muscle progenitor cells led to a reduction of nuclei number in myosin heavy chain (MHC)-positive myotubes (29).”
From The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity (2023) · cites this paper as [29]
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- Authors
- Takegahara, Y., Yamanouchi, K., Nakamura, K., Nakano, S.-I., & Nishihara, M.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Yamanouchi, Keitaro
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 324
- Issue
- 1
- Pages
- 105-114
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2066125811
- Cited by
- 53
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 1 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23228004, 25292185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- intramuscular fat, myotube formation, myogenesis, adipocytes, preadipocytes, PPARγ, skeletal muscle progenitor cells, cell-cell contact, Duchenne muscular dystrophy, sarcopenia, myosin heavy chain, conditioned medium, skeletal muscle mass
- MeSH terms
- Animals, Cell Communication, Cells, Cultured, Male, Stem Cells, Rats, Wistar, Adipocytes, Muscle Fibers, Skeletal, Coculture Techniques, Cell Lineage, Muscle Development, RNA, Small Interfering, PPAR gamma, Adipogenesis, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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