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Cited by 348Epigenetics and DNA MethylationStress Responses and CortisolNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

Szyf, Moshe, Weaver, Ian C.G., Champagne, Francis A., Diorio, Josie, Meaney, Michael J.·2005·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2005.10.002
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Abstract

Increased levels of pup licking/grooming and arched-back nursing by rat mothers over the first week of life alter the epigenome at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. Differences in the DNA methylation pattern between the offspring of High and Low licking/grooming--arched-back mothers emerge over the first week of life, are reversed with cross-fostering, persist into adulthood and are associated with altered histone acetylation and transcription factor (NGFI-A) binding to the glucocorticoid receptor promoter. Central infusion of the adult offspring with the histone deacetylase inhibitor trichostatin A removes the previously defined epigenomic group differences in histone acetylation, DNA methylation, NGFI-A binding, glucocorticoid receptor expression, and hypothalamic-pituitary-adrenal responses to stress, thus suggesting a causal relation between the epigenomic state, glucocorticoid receptor expression and the effects of maternal care on stress responses in the offspring. These findings demonstrate that an epigenomic state of a gene can be established through a behavioral mode of programming and that in spite of the inherent stability of this epigenomic mark, it is dynamic and potentially reversible.

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Research works printed but not linked: 6

  1. Chrousos, 1992, The concepts of stress and stress system disorders, J. Am. Med. Assoc., 267, 1244, 10.1001/jama.267.9.1244 · DOI · Paper page
  2. Hellstrom, 2004, Ex vivo characterization of maternal programming of stress responses through modulation of the epigenome, Soc. Neurosci. Abst., 23, 662.11
  3. Meaney, 2005, Environmentally-driven chromatin plasticity?, Trends Neurosci.
  4. Pedersen, 1995, Oxytocin control of maternal behavior. Regulation by sex steriods and offspring stimuli, Ann. NY Acad. Sci., 126, 126
  5. Rinne, 2001, Hyperresponsiveness hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality subjects with a history of sustained childhood abuse, Biol. Psychiatry, 49, 1102
  6. Shahrokh, 2005, Increased oxytocin expression in the medial preoptic area and enhanced oxytocin projections to the ventral tegmental area in high licking/grooming rat mothers, Soc. Neurosci. Abst.

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Metadata

Authors
Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J.
Affiliations
Douglas Mental Health University Institute (CA)
Corresponding author
Meaney, Michael J.
ORCID
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2005-10
Volume
26
Issue
3-4
Pages
139-162
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2005.10.002
OpenAlex
W2146840535
Cited by
348
References
249
Citations by year
2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 17 · 2013: 27 · 2012: 27
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
maternal programming, DNA methylation, glucocorticoid receptor, hippocampus, epigenetic inheritance, histone acetylation, NGFI-A, trichostatin A, stress response, cross-fostering
MeSH terms
Animals, Corticotropin-Releasing Hormone, Female, Gene Expression Regulation, Grooming, Hippocampus, Interpersonal Relations, Male, Maternal Behavior, Phenotype, Promoter Regions, Genetic, Receptors, Glucocorticoid, Stress, Psychological, DNA Methylation, Epigenesis, Genetic, Rats

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