The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
Abstract
Increased levels of pup licking/grooming and arched-back nursing by rat mothers over the first week of life alter the epigenome at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. Differences in the DNA methylation pattern between the offspring of High and Low licking/grooming--arched-back mothers emerge over the first week of life, are reversed with cross-fostering, persist into adulthood and are associated with altered histone acetylation and transcription factor (NGFI-A) binding to the glucocorticoid receptor promoter. Central infusion of the adult offspring with the histone deacetylase inhibitor trichostatin A removes the previously defined epigenomic group differences in histone acetylation, DNA methylation, NGFI-A binding, glucocorticoid receptor expression, and hypothalamic-pituitary-adrenal responses to stress, thus suggesting a causal relation between the epigenomic state, glucocorticoid receptor expression and the effects of maternal care on stress responses in the offspring. These findings demonstrate that an epigenomic state of a gene can be established through a behavioral mode of programming and that in spite of the inherent stability of this epigenomic mark, it is dynamic and potentially reversible.
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“The absence of early nurturing maternal behavior in rodents leads to increased methylation, a covalent modification involved in epigenetic regulation of DNA, of exon 17, a NGFI-A regulated promoter of the GR NR3C1 gene (Meaney & Szyf, 2005; Szyf, Weaver, Champagne, Diorio, & Meaney, 2005).”
From Associations Between Early Life Stress and Gene Methylation in Children (2015) · cites this paper as Szyf et al., 2005
In the citing paper
“Likewise the increased CpG methylation within the GR promotor is associated with a sluggish HPA stress response and is associated with poor maternal care in rodents and early life abuse in human suicide victims.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [32]
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Cited by
Sorted by citations
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Mechanisms of stress in the brain
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Neurobiological and Systemic Effects of Chronic Stress
McEwen, B. S. (2017) · Chronic Stress · doi:10.1177/2470547017692328 · Cited by 1,059
Metadata
- Authors
- Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Meaney, Michael J.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 26
- Issue
- 3-4
- Pages
- 139-162
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2146840535
- Cited by
- 348
- References
- 249
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 17 · 2013: 27 · 2012: 27
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- maternal programming, DNA methylation, glucocorticoid receptor, hippocampus, epigenetic inheritance, histone acetylation, NGFI-A, trichostatin A, stress response, cross-fostering
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Female, Gene Expression Regulation, Grooming, Hippocampus, Interpersonal Relations, Male, Maternal Behavior, Phenotype, Promoter Regions, Genetic, Receptors, Glucocorticoid, Stress, Psychological, DNA Methylation, Epigenesis, Genetic, Rats
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