Epigenetic Programming by Maternal Behavior and Pharmacological Intervention Nature Versus Nurture: Let's Call The Whole Thing Off
Open accessAbstract
The nature of maternal care that an infant receives can effect the child's emotional and cognitive development, which is endured into adulthood. Similarly, maternal behavior in rodents is associated with long-term programming of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the offspring. One critical question is how is such 'environmental programming' established and sustained in the offspring? This review discusses a novel mechanism to explain how maternal licking/grooming behavior in the rat can alter the hippocampal glucocorticoid receptor (GR) expression in the offspring, which concomitantly alters the HPA axis and the stress responsiveness of these animals. Both in vivo and in vitro studies show that maternal behavior increases GR expression in the offspring via increased hippocampal serotonergic tone accompanied by increased histone acetylase transferase activity, histone acetylation and DNA demethylation mediated by the transcription factor NGFI-A. In summary, this research demonstrates that an epigenetic state of a gene can be established through early-in-life experience, and is potentially reversible in adulthood. Accordingly, epigenetic modifications of specific genomic regions in response to variations in environmental conditions might serve as a major source of variation in biological and behavioral phenotypes.
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In rats, maternal licking and grooming, which is central to HPA stress response development, acts through molecular mechanisms that change the epigenetic state of the hippocampal gene coding for glucocorticoid receptor density.
“Remarkably, research has shown that the maternal licking and grooming behavior in the rat that is so central to the development of the HPA stress response system produces its effect through molecular mechanisms that alter the epigenetic state of the gene that codes for GR receptor density in the hippocampus (Meaney & Szyf, 2005; Weaver, 2007; Weaver et al., 2004).”
From Stress and the development of self-regulation in context (2010) · cites this paper as Weaver, 2007
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“…behavior in the rat that is so central to the development of the HPA stress response system produces its effect through molecular mechanisms that alter the epigenetic state of the gene that codes for GR receptor density in the hippocampus (Meaney & Szyf, 2005; Weaver, 2007; Weaver et al., 2004).”
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- Authors
- Weaver, I. C. G.
- Affiliations
- Hospital for Sick Children (CA)
- Corresponding author
- Weaver, Ian C.G.
- ORCID
- Weaver, Ian C.G.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2007-01-10
- Volume
- 2
- Issue
- 1
- Pages
- 22-28
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2131820654
- Cited by
- 239
- References
- 65
- Citations by year
- 2026: 10 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 18 · 2014: 26 · 2013: 18 · 2012: 23
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epigenetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Cancer Institute
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- maternal behavior, epigenetic programming, glucocorticoid receptor, hippocampus, hypothalamic-pituitary-adrenal axis, stress responsiveness, histone acetylation, DNA methylation, NGFI-A, environmental programming, nature versus nurture
- MeSH terms
- Adult, Child, Female, Glucocorticoids, Humans, Hypothalamus, Maternal Behavior, Models, Psychological, Mother-Child Relations, Epigenesis, Genetic
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