Cited by 348Epigenetics and DNA MethylationStress Responses and CortisolNeuroendocrine regulation and behavior

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Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

Szyf, Moshe, Weaver, Ian C.G., Champagne, Francis A., Diorio, Josie, Meaney, Michael J.·2005·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2005.10.002

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Abstract

Increased levels of pup licking/grooming and arched-back nursing by rat mothers over the first week of life alter the epigenome at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. Differences in the DNA methylation pattern between the offspring of High and Low licking/grooming--arched-back mothers emerge over the first week of life, are reversed with cross-fostering, persist into adulthood and are associated with altered histone acetylation and transcription factor (NGFI-A) binding to the glucocorticoid receptor promoter. Central infusion of the adult offspring with the histone deacetylase inhibitor trichostatin A removes the previously defined epigenomic group differences in histone acetylation, DNA methylation, NGFI-A binding, glucocorticoid receptor expression, and hypothalamic-pituitary-adrenal responses to stress, thus suggesting a causal relation between the epigenomic state, glucocorticoid receptor expression and the effects of maternal care on stress responses in the offspring. These findings demonstrate that an epigenomic state of a gene can be established through a behavioral mode of programming and that in spite of the inherent stability of this epigenomic mark, it is dynamic and potentially reversible.

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Authors: Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J.
Affiliations: Douglas Mental Health University Institute (CA)
Corresponding author: Meaney, Michael J.
ORCID: Weaver, Ian C.G.
Meaney, Michael J.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2005-10
Volume: 26
Issue: 3-4
Pages: 139-162
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2005.10.002
OpenAlex: W2146840535
Cited by: 348
References: 249
Citations by year: 2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 14 · 2016: 21 · 2015: 27 · 2014: 17 · 2013: 27 · 2012: 27
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: maternal programming, DNA methylation, glucocorticoid receptor, hippocampus, epigenetic inheritance, histone acetylation, NGFI-A, trichostatin A, stress response, cross-fostering
MeSH terms: Animals, Corticotropin-Releasing Hormone, Female, Gene Expression Regulation, Grooming, Hippocampus, Interpersonal Relations, Male, Maternal Behavior, Phenotype, Promoter Regions, Genetic, Receptors, Glucocorticoid, Stress, Psychological, DNA Methylation, Epigenesis, Genetic, Rats

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Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

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