Cited by 180Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingNeurological disorders and treatments

Sex differences in Parkinson’s disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics

Jurado-Coronel, Juan Camilo, Cabezas, Ricardo, Ávila Rodríguez, Marco Fidel, Echeverria, Valentina, García-Segura, Luis Miguel, Barreto, George E.·2018·Frontiers in Neuroendocrinology

Abstract

Parkinson's disease (PD) is the second most frequent age-related neurodegenerative disorder. Sex is an important factor in the development of PD, as reflected by the fact that it is more common in men than in women by an approximate ratio of 2:1. Our hypothesis is that differences in PD among men and women are highly determined by sex-dependent differences in the nigrostriatal dopaminergic system, which arise from environmental, hormonal and genetic influences. Sex hormones, specifically estrogens, influence PD pathogenesis and might play an important role in PD differences between men and women. The objective of this review was to discuss the PD physiopathology and point out sex differences in nigrostriatal degeneration, symptoms, genetics, responsiveness to treatments and biochemical and molecular mechanisms among patients suffering from this disease. Finally, we discuss the role estrogens may have on PD sex differences.

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Crossref · 10.1016/j.yfrne.2017.09.002

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Authors
Jurado-Coronel, J. C., Cabezas, R., Ávila Rodríguez, M. F., Echeverria, V., García-Segura, L. M., & Barreto, G. E.
Affiliations
Pontificia Universidad Javeriana (CO)
Corresponding author
Barreto, George E.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2018-07
Volume
50
Pages
18-30
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2758095848
Cited by
180
References
121
Citations by year
2026: 19 · 2025: 29 · 2024: 24 · 2023: 23 · 2022: 25 · 2021: 23 · 2020: 17 · 2019: 11 · 2018: 9
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
PUJ (5623)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Parkinson's disease, sex differences, sex hormones, estrogen, nigrostriatal pathway, clinical symptoms, treatment response, genetic susceptibility, neurodegeneration, sex ratio
MeSH terms
Animals, Female, Humans, Male, Parkinson Disease, Sex Characteristics, Gonadal Steroid Hormones, Outcome Assessment, Health Care

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