Cited by 326Gut microbiota and healthGastrointestinal motility and disordersRegulation of Appetite and Obesity

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The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

Open access

Cussotto, Sofia, Sandhu, Kiran V., Dinan, Timothy G., Cryan, John F.·2018·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2018.04.002

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Abstract

The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.

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“00 09 1v 1 虽然当前抗精神病药物对精神分裂症患者的阳性和阴性症状的治疗效果较好，但对患者的认知功能损伤没有较好的治疗效果，因此需要进一步探究精神分裂症患者认知功能损伤的原因(Hori et al., 2006)。目前研究发现，在精神分裂症的早期阶段，认知功能的损伤被认为与炎症过程有关，而肠道微生物可通过影响糖皮质激素和免疫介质的产生参与这一过程(Cabrera et al., 2016; Cussotto et al., 2018)。大脑多个脑区的异常激活、脑结构的异常被认为与认知功能的受损以及临…”
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Authors: Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: Cryan, John F.
ORCID: Cussotto, Sofia
Dinan, Timothy G.
Cryan, John F.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2018-10
Volume: 51
Pages: 80-101
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2018.04.002
OpenAlex: W2804326576
Cited by: 326
References: 407
Citations by year: 2026: 17 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 54 · 2021: 36 · 2020: 43 · 2019: 32 · 2018: 5
FWCI: 2.84
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: gut microbiota, gut-brain axis, neuroendocrine system, behavioral responses, stress, eating behaviour, sexual behavior, social behavior, cognition, addiction, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Feeding Behavior, Humans, Learning, Neurosecretory Systems, Sexual Behavior, Social Behavior, Stress, Psychological, Behavior, Addictive

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The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

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