The DOI matches its Crossref record; 402 of the 407 references it cites were found in a registry or an index.
The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective
Open accessAbstract
The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This relationship, like the microbiota-gut-brain axis itself, is bidirectional -the microbiota can modulate stress-induced alterations in anxiety, memory, cognition and neuroinflammation (for reviews, see Cussotto et al., 2018;Farzi et al., 2018;Foster et al., 2017;Rea et al., 2016;Sherwin et al., 2016a).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Cussotto et al., 2018
In the citing paper
“The development of the blood-brain barrier is now well established to be contingent upon the presence of commensal gut flora (10, 11).”
From Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2019) · cites this paper as [10]
Citations
Cites
1 retracted
Million, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., Vialettes, B., & Raoult, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.20 · Cited by 362
RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · cited 2×
“germ-free mice with an obese microbiota resulted in a significantly greater increase in total body fat than colonization with a lean microbiota (Turnbaugh et al., 2006).”
BackgroundA human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · cited 2×
“to obesity and this can occur in a causative way (Backhed et al., 2004; Ley et al., 2006; Ridaura et al., 2013; Turnbaugh et al., 2009b).”
BackgroundA core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · cited 1×
“host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, thus improving host health” (Gibson and Roberfroid, 1995) but this concept has been expanded more recently (Bindels et al.”
BackgroundLinking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · cited 1×
“33 microbiota composition (Conlon and Bird, 2014; De Filippo et al., 2010; Queipo-Ortuno et al., 2013; Wu et al., 2011); however the converse might also be true.”
BackgroundThe gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · cited 1×
“Both obese humans and mice have been shown to have a specific microbial profile that is different from lean people, with the relative proportion of Bacteroidetes decreased in obese subjects (Ley et al., 2005; Ley et al., 2006).”
BackgroundDe Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Research works printed but not linked: 2
- Chrousos, 1995, The hypothalamic–pituitary–adrenal axis and immune-mediated inflammation, N. Engl. J. Med., 332, 1351, 10.1056/NEJM199505183322008 · DOI · Paper page
- Tsigos, 2002, Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress, J. Psychosom. Res., 53, 865, 10.1016/S0022-3999(02)00429-4 · DOI · Paper page
Cited by
Sorted by citations
Items 301–326 of 326
TAXAPRO: A Streamlined Pipeline to Analyze Shotgun Metagenomes
Sehli, S., Ouafi, Z. E., Eddington, C., Jbara, S., Kasambula, A. S., Jaddaoui, I. E., Afolayan, A. O., Awe, O. I., Dillman, A., & Ghazal, H. (2024) · Lecture notes in networks and systems · doi:10.1007/978-3-031-52385-4_8
Yeme bağımlılığına bağırsak mikrobiyotası üzerinden bakış
Erkul, C. (2024) · Journal of Dependence · doi:10.51982/bagimli.1434199
Traina, G. (2024) · Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale · doi:10.4081/jbr.2024.12362
Investigating the mechanistic role of oxidative stress in brain–gut axis disruption in rat model
Sikiru, A. B., Egena, S. A., Adio, K. M., Morufat, A. E., Adam, M., & Abdullahi, A. (2024) · Academia Biology · doi:10.20935/acadbiol7409
Wang, J., Hu, C., Gao, Y., Shao, X., Ma, J., Dai, Y., & Zhao, K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5258804
Wang, J., Hu, C., Gao, Y., Shao, X., Ma, J., Dai, Y., & Zhao, K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5276377
The Gut Microbiome and Cardiac Arrhythmias
Vautier, R. A. (2025) · Federal Practitioner · doi:10.12788/fp.0595
Gut as a second brain and its role in neurological diseases
Kumar, N., Ashokan, A., Singh, A., & Vellingiri, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29932-2.00001-3 · Cited by 1
Influence of gut microbiota on axonal cells of the brain
Suresh, G., Srivastava, S., & Singh, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29932-2.00004-9 · Cited by 1
The application of fecal microbiota transplantation in Parkinson’s disease
Wang, B., Ma, D., Li, N., & Luo, T. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1713899
Tirelle, P., Breton, J., Riou, G., Déchelotte, P., Coëffier, M., & Ribet, D. (2020) · Figshare · doi:10.6084/m9.figshare.13226245
Tirelle, P., Breton, J., Riou, G., Déchelotte, P., Coëffier, M., & Ribet, D. (2020) · Figshare · doi:10.6084/m9.figshare.13226248
Tirelle, P., Breton, J., Riou, G., Déchelotte, P., Coëffier, M., & Ribet, D. (2020) · Figshare · doi:10.6084/m9.figshare.13226242
Dietary modulation of gut microbiota and gut–brain axis
Viana, S., Ferreira, C., Violante, C., Hinchado, M. D., & Reis, F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33841-0.00017-8
Impact de la consommation de fructose sur la microglie et la santé cérébrale
Coursan, A. (2024) · theses.fr (ABES) · doi:10.70675/c509f961z7098z4c0bz92b0z8ba14be2e725
The Gut-Brain Axis—From Science to Clinical Practice
Quigley, E. M. M. (2026) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.100975
Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing ratePreprint
Takaochi, A., Abe, K., Sugiura, Y., Kawaguchi, A., Kuraku, S., Tanaka, H.-N., Motooka, D., Tanaka, K., Ferdousi, F., Nagasaki, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721799 · Cited by 1
The Microbiome-Body Connection: Unraveling the Gut-Brain Axis
Islam, M. M., Mahbub, N. U., & Islam, M. A. (2026) · Springer eBooks · doi:10.1007/978-981-95-7494-0_1
Sobti, R. C., Negi, R. K., & Rana, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-9031-5_1
Gut microbiota-mediated neuroinflammation following stroke: mechanisms and intervention strategies
Teng, L., Wu, M., Song, W., Wang, Q., Luo, X., & Zhu, L. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08694-x
“Early exposure to LPS can exert long-term effects on the HPA axis, particularly in adulthood, as evidenced by adrenocorticotropic hormone and corticosterone responses, and weakened glucocorticoid negative feed-back inhibition [98].”
Zebrafish as a translational model for peptide-mediated synaptic dysfunction related to obesity
Rodrigues, A. C., Lacerda, A. P., Mukoyama, L. T. H., de Carvalho, G. B., da Mata, J. A. L., Buccini, D. F., Franco, O. L., & Migliolo, L. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1845252
“Furthermore, the gut microbiota produces neurotransmitters and neuromodulators, including catecholamines, GABA, and tryptophan-derived metabolites, which influence hypothalamic activity, neuroendocrine signaling, and neurodevelopment (Cussotto et al., 2018; Wang et al., 2023).”
Periodontitis Exacerbates Insulin Resistance via Gut Barrier Dysfunction and TLR4/NF-κB Activation
Jiang, L., Huang, Y., Zhang, S., Li, X., Mo, F., Huang, C., & Tao, R. (2026) · International Dental Journal · doi:10.1016/j.identj.2026.109818
“19 Moreover, periodontal microorganisms such as Streptococcus and Veillonella have been detected in the intestines of patients with T2DM.”
Biological mechanisms underlying avoidant/restrictive food intake disorder (ARFID)
Дремук, И. А., & Smolensky, I. V. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.09.002
Cubitt, M., Ellenbroek, B. A., & Haase, A. M. (2026) · Biomolecules · doi:10.3390/biom16101397
Wang, J., Hu, C., Gao, Y., Shao, X., 马建忠, 戴杨鑫, Wang, X., & Zhao, K. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103866
Metadata
- Authors
- Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Cryan, John F.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 51
- Pages
- 80-101
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2804326576
- Cited by
- 326
- References
- 407
- Citations by year
- 2026: 17 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 54 · 2021: 36 · 2020: 43 · 2019: 32 · 2018: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gut microbiota, gut-brain axis, neuroendocrine system, behavioral responses, stress, eating behaviour, sexual behavior, social behavior, cognition, addiction, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Feeding Behavior, Humans, Learning, Neurosecretory Systems, Sexual Behavior, Social Behavior, Stress, Psychological, Behavior, Addictive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
