Cited by 326Gut microbiota and healthGastrointestinal motility and disordersRegulation of Appetite and Obesity

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The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

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Cussotto, Sofia, Sandhu, Kiran V., Dinan, Timothy G., Cryan, John F.·2018·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2018.04.002

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Abstract

The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.

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“HPA is one of the main endocrine system axis (Cussotto et al. 2018 ), that regulates the effi - cacy and release of monoamine neurotransmitters, modifies the abundance of BDNF, and activates immune responses and systemic inflammation.”
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Gut microbiota in obesity and related complications: Unveiling the complex interplay
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Authors: Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: Cryan, John F.
ORCID: Cussotto, Sofia
Dinan, Timothy G.
Cryan, John F.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2018-10
Volume: 51
Pages: 80-101
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2018.04.002
OpenAlex: W2804326576
Cited by: 326
References: 407
Citations by year: 2026: 17 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 54 · 2021: 36 · 2020: 43 · 2019: 32 · 2018: 5
FWCI: 2.84
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: gut microbiota, gut-brain axis, neuroendocrine system, behavioral responses, stress, eating behaviour, sexual behavior, social behavior, cognition, addiction, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Feeding Behavior, Humans, Learning, Neurosecretory Systems, Sexual Behavior, Social Behavior, Stress, Psychological, Behavior, Addictive

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The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

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