The DOI matches its Crossref record; 402 of the 407 references it cites were found in a registry or an index.
The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective
Open accessAbstract
The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction.
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“This relationship, like the microbiota-gut-brain axis itself, is bidirectional -the microbiota can modulate stress-induced alterations in anxiety, memory, cognition and neuroinflammation (for reviews, see Cussotto et al., 2018;Farzi et al., 2018;Foster et al., 2017;Rea et al., 2016;Sherwin et al., 2016a).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Cussotto et al., 2018
In the citing paper
“The development of the blood-brain barrier is now well established to be contingent upon the presence of commensal gut flora (10, 11).”
From Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2019) · cites this paper as [10]
Citations
Cites
1 retracted
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Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15122749 · Cited by 933
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 767
“A notable role of human digestive system in brain development has been proposed [15, 50].”
BackgroundGut Microbiota and Energy Homeostasis in Fish
Butt, R. L., & Volkoff, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00009 · Cited by 637
McGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01456-3 · Cited by 502
“They influence many aspects of physiology via neural, hormonal and immunological pathways [1, 2], so much so that some describe the gut microbiome as a ‘virtual organ’ [3, 4].”
Background
Metadata
- Authors
- Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Cryan, John F.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 51
- Pages
- 80-101
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2804326576
- Cited by
- 326
- References
- 407
- Citations by year
- 2026: 17 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 54 · 2021: 36 · 2020: 43 · 2019: 32 · 2018: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gut microbiota, gut-brain axis, neuroendocrine system, behavioral responses, stress, eating behaviour, sexual behavior, social behavior, cognition, addiction, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Feeding Behavior, Humans, Learning, Neurosecretory Systems, Sexual Behavior, Social Behavior, Stress, Psychological, Behavior, Addictive
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